How SARS-CoV-2 and Other Viruses Build an Invasion Route to Hijack the Host Nucleocytoplasmic Trafficking System

The host nucleocytoplasmic trafficking system is often hijacked by viruses to accomplish their replication and to suppress the host immune response. Viruses encode many factors that interact with the host nuclear transport receptors (NTRs) and the nucleoporins of the nuclear pore complex (NPC) to ac...

Descripción completa

Detalles Bibliográficos
Autores principales: Sajidah, Elma Sakinatus, Lim, Keesiang, Wong, Richard W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230057/
https://www.ncbi.nlm.nih.gov/pubmed/34200500
http://dx.doi.org/10.3390/cells10061424
_version_ 1783713117387096064
author Sajidah, Elma Sakinatus
Lim, Keesiang
Wong, Richard W.
author_facet Sajidah, Elma Sakinatus
Lim, Keesiang
Wong, Richard W.
author_sort Sajidah, Elma Sakinatus
collection PubMed
description The host nucleocytoplasmic trafficking system is often hijacked by viruses to accomplish their replication and to suppress the host immune response. Viruses encode many factors that interact with the host nuclear transport receptors (NTRs) and the nucleoporins of the nuclear pore complex (NPC) to access the host nucleus. In this review, we discuss the viral factors and the host factors involved in the nuclear import and export of viral components. As nucleocytoplasmic shuttling is vital for the replication of many viruses, we also review several drugs that target the host nuclear transport machinery and discuss their feasibility for use in antiviral treatment.
format Online
Article
Text
id pubmed-8230057
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-82300572021-06-26 How SARS-CoV-2 and Other Viruses Build an Invasion Route to Hijack the Host Nucleocytoplasmic Trafficking System Sajidah, Elma Sakinatus Lim, Keesiang Wong, Richard W. Cells Review The host nucleocytoplasmic trafficking system is often hijacked by viruses to accomplish their replication and to suppress the host immune response. Viruses encode many factors that interact with the host nuclear transport receptors (NTRs) and the nucleoporins of the nuclear pore complex (NPC) to access the host nucleus. In this review, we discuss the viral factors and the host factors involved in the nuclear import and export of viral components. As nucleocytoplasmic shuttling is vital for the replication of many viruses, we also review several drugs that target the host nuclear transport machinery and discuss their feasibility for use in antiviral treatment. MDPI 2021-06-07 /pmc/articles/PMC8230057/ /pubmed/34200500 http://dx.doi.org/10.3390/cells10061424 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sajidah, Elma Sakinatus
Lim, Keesiang
Wong, Richard W.
How SARS-CoV-2 and Other Viruses Build an Invasion Route to Hijack the Host Nucleocytoplasmic Trafficking System
title How SARS-CoV-2 and Other Viruses Build an Invasion Route to Hijack the Host Nucleocytoplasmic Trafficking System
title_full How SARS-CoV-2 and Other Viruses Build an Invasion Route to Hijack the Host Nucleocytoplasmic Trafficking System
title_fullStr How SARS-CoV-2 and Other Viruses Build an Invasion Route to Hijack the Host Nucleocytoplasmic Trafficking System
title_full_unstemmed How SARS-CoV-2 and Other Viruses Build an Invasion Route to Hijack the Host Nucleocytoplasmic Trafficking System
title_short How SARS-CoV-2 and Other Viruses Build an Invasion Route to Hijack the Host Nucleocytoplasmic Trafficking System
title_sort how sars-cov-2 and other viruses build an invasion route to hijack the host nucleocytoplasmic trafficking system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230057/
https://www.ncbi.nlm.nih.gov/pubmed/34200500
http://dx.doi.org/10.3390/cells10061424
work_keys_str_mv AT sajidahelmasakinatus howsarscov2andothervirusesbuildaninvasionroutetohijackthehostnucleocytoplasmictraffickingsystem
AT limkeesiang howsarscov2andothervirusesbuildaninvasionroutetohijackthehostnucleocytoplasmictraffickingsystem
AT wongrichardw howsarscov2andothervirusesbuildaninvasionroutetohijackthehostnucleocytoplasmictraffickingsystem

Ejemplares similares