Cargando…

Melanoma Cell State-Specific Responses to TNFα

Immune checkpoint inhibitors that target the programmed cell death protein 1 (PD1) pathway have revolutionized the treatment of patients with advanced metastatic melanoma. PD1 inhibitors reinvigorate exhausted tumor-reactive T cells, thus restoring anti-tumor immunity. Tumor necrosis factor alpha (T...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lim, Su Yin, Alavi, Sara, Ming, Zizhen, Shklovskaya, Elena, Fung, Carina, Stewart, Ashleigh, Rizos, Helen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230114/ https://www.ncbi.nlm.nih.gov/pubmed/34073253 http://dx.doi.org/10.3390/biomedicines9060605

Ejemplares similares

Interferon Signaling Is Frequently Downregulated in Melanoma
por: Alavi, Sara, et al.
Publicado: (2018)

Durable Responses to Anti-PD1 and Anti-CTLA4 in a Preclinical Model of Melanoma Displaying Key Immunotherapy Response Biomarkers
por: Shklovskaya, Elena, et al.
Publicado: (2022)

The molecular and functional landscape of resistance to immune checkpoint blockade in melanoma
por: Lim, Su Yin, et al.
Publicado: (2023)

Genetic Alterations in the INK4a/ARF Locus: Effects on Melanoma Development and Progression
por: Ming, Zizhen, et al.
Publicado: (2020)

Spatial and Temporal Changes in PD-L1 Expression in Cancer: The Role of Genetic Drivers, Tumor Microenvironment and Resistance to Therapy
por: Shklovskaya, Elena, et al.
Publicado: (2020)

MHC Class I Deficiency in Solid Tumors and Therapeutic Strategies to Overcome It
por: Shklovskaya, Elena, et al.
Publicado: (2021)

Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition
por: Lee, Jenny H., et al.
Publicado: (2020)

Protein kinase inhibitor responses in uveal melanoma reflects a diminished dependency on PKC-MAPK signaling
por: Park, John J., et al.
Publicado: (2022)

Tumor MHC Expression Guides First-Line Immunotherapy Selection in Melanoma
por: Shklovskaya, Elena, et al.
Publicado: (2020)

Oncogenic PI3K/AKT promotes the step-wise evolution of combination BRAF/MEK inhibitor resistance in melanoma
por: Irvine, Mal, et al.
Publicado: (2018)

SERS characterization of colorectal cancer cell surface markers upon anti‐EGFR treatment
por: Lyu, Nana, et al.
Publicado: (2022)

Liquid biomarkers in melanoma: detection and discovery
por: Lim, Su Yin, et al.
Publicado: (2018)

Immune cell profiling in the age of immune checkpoint inhibitors: implications for biomarker discovery and understanding of resistance mechanisms
por: Lim, Su Yin, et al.
Publicado: (2018)

TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma
por: Bertrand, Florie, et al.
Publicado: (2017)

Overexpression of TNFα induces senescence, autophagy and mitochondrial dysfunctions in melanoma cells
por: Tyciakova, Silvia, et al.
Publicado: (2021)

Anchored Multiplex PCR Custom Melanoma Next Generation Sequencing Panel for Analysis of Circulating Tumor DNA
por: Diefenbach, Russell J., et al.
Publicado: (2022)

PD-1 Blockade on Tumor Microenvironment-Resident ILC2s Promotes TNF-α Production and Restricts Progression of Metastatic Melanoma
por: Howard, Emily, et al.
Publicado: (2021)

The TNF-α-308G/A Gene Polymorphism and Serum TNF-α Levels in Women With Preeclampsia
por: Khodadadi, Allahdad, et al.
Publicado: (2022)

Resistance to c-Kit inhibitors in melanoma: insights for future therapies
por: Carlino, Matteo S., et al.
Publicado: (2014)

Anti-TNF-α Drugs Differently Affect the TNFα-sTNFR System and Monocyte Subsets in Patients with Psoriasis
por: Gibellini, Lara, et al.
Publicado: (2016)

Methylated circulating tumor DNA as a biomarker in cutaneous melanoma
por: Diefenbach, Russell J, et al.
Publicado: (2020)

TNF-α increases human melanoma cell invasion and migration in vitro: the role of proteolytic enzymes
por: Katerinaki, E, et al.
Publicado: (2003)

Investigation of TNF-α and IL-6 Levels in the Sera of Non-Melanoma Skin Cancer Patients
por: Ghahartars, Mehdi, et al.
Publicado: (2021)

Clinical significance of intronic variants in BRAF inhibitor resistant melanomas with altered BRAF transcript splicing
por: Pupo, Gulietta M., et al.
Publicado: (2017)

Inhibition of transmembrane TNF-α shedding by a specific antibody protects against septic shock
por: Li, Chenxi, et al.
Publicado: (2019)

Behҫet’s Disease, and the Role of TNF-α and TNF-α Blockers
por: van der Houwen, Tim, et al.
Publicado: (2020)

TNF-α/anti-TNF-α drugs and its effect on pregnancy outcomes
por: Dai, Fang-fang, et al.
Publicado: (2022)

Paradoxical Psoriasis Induced by Anti-TNFα Treatment: Evaluation of Disease-Specific Clinical and Genetic Markers
por: Bucalo, Agostino, et al.
Publicado: (2020)

Association of TNF-α polymorphisms (−857, −863 and −1031), TNF-α serum level and lipid profile with acne vulgaris
por: Younis, Sidra, et al.
Publicado: (2021)

Assessment of Anti-TNF-α Activities in Keratinocytes Expressing Inducible TNF- α: A Novel Tool for Anti-TNF-α Drug Screening
por: Udommethaporn, Sutthirat, et al.
Publicado: (2016)

TNF-α and Beyond: Rapid Mitochondrial Dysfunction Mediates TNF-α-Induced Neurotoxicity
por: Russell, Ashley E., et al.
Publicado: (2016)

The Role of TNF-α and Anti-TNF-α Agents during Preconception, Pregnancy, and Breastfeeding
por: Romanowska-Próchnicka, Katarzyna, et al.
Publicado: (2021)

TNF-α in Uveitis: From Bench to Clinic
por: Jiang, Qi, et al.
Publicado: (2021)

Development of primary malignant melanoma during treatment with a TNF-α antagonist for severe Crohn’s disease: a case report and review of the hypothetical association between TNF-α blockers and cancer
por: Kouklakis, George, et al.
Publicado: (2013)

TNF-R1, an immune checkpoint in melanoma?
por: Bertrand, Florie, et al.
Publicado: (2015)

TNF-α inhibitors: are they carcinogenic?
por: Raval, Girindra, et al.
Publicado: (2010)

TNFα-induced metabolic reprogramming drives an intrinsic anti-viral state
por: Ciesla, Jessica, et al.
Publicado: (2022)

The Association of Serum TNF-α Levels and Blood Multi-Elements Modified by TNF-α Gene Polymorphisms in Metal Industrial Workers
por: Chen, Tzu-Hua, et al.
Publicado: (2019)

Intestinal-Specific TNFα Overexpression Induces Crohn’s-Like Ileitis in Mice
por: Bamias, Giorgos, et al.
Publicado: (2013)

The Antiviral Effects of Jasminin via Endogenous TNF-α and the Underlying TNF-α-Inducing Action
por: Zhu, Xiaohong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_o1pkiji4iuk4mbdd17kfbk5aet