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Endometrial Perivascular Progenitor Cells and Uterus Regeneration

Ovarian steroid-regulated cyclical regeneration of the endometrium is crucial for endometrial receptivity and embryo implantation, and it is dependent on the dynamic remodeling of the endometrial vasculature. Perivascular cells, including pericytes surrounding capillaries and microvessels and advent...

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Detalles Bibliográficos
Autores principales: Li, Shiyuan, Ding, Lijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230145/
https://www.ncbi.nlm.nih.gov/pubmed/34071743
http://dx.doi.org/10.3390/jpm11060477
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author Li, Shiyuan
Ding, Lijun
author_facet Li, Shiyuan
Ding, Lijun
author_sort Li, Shiyuan
collection PubMed
description Ovarian steroid-regulated cyclical regeneration of the endometrium is crucial for endometrial receptivity and embryo implantation, and it is dependent on the dynamic remodeling of the endometrial vasculature. Perivascular cells, including pericytes surrounding capillaries and microvessels and adventitial cells located in the outermost layer of large vessels, show properties of mesenchymal stem cells, and they are thus promising candidates for uterine regeneration. In this review, we discuss the structure and functions of the endometrial blood vasculature and their roles in endometrial regeneration, the main biomarkers and characteristics of perivascular cells in the endometrium, and stem cell-based angiogenetic therapy for Asherman’s syndrome.
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spelling pubmed-82301452021-06-26 Endometrial Perivascular Progenitor Cells and Uterus Regeneration Li, Shiyuan Ding, Lijun J Pers Med Review Ovarian steroid-regulated cyclical regeneration of the endometrium is crucial for endometrial receptivity and embryo implantation, and it is dependent on the dynamic remodeling of the endometrial vasculature. Perivascular cells, including pericytes surrounding capillaries and microvessels and adventitial cells located in the outermost layer of large vessels, show properties of mesenchymal stem cells, and they are thus promising candidates for uterine regeneration. In this review, we discuss the structure and functions of the endometrial blood vasculature and their roles in endometrial regeneration, the main biomarkers and characteristics of perivascular cells in the endometrium, and stem cell-based angiogenetic therapy for Asherman’s syndrome. MDPI 2021-05-27 /pmc/articles/PMC8230145/ /pubmed/34071743 http://dx.doi.org/10.3390/jpm11060477 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Shiyuan
Ding, Lijun
Endometrial Perivascular Progenitor Cells and Uterus Regeneration
title Endometrial Perivascular Progenitor Cells and Uterus Regeneration
title_full Endometrial Perivascular Progenitor Cells and Uterus Regeneration
title_fullStr Endometrial Perivascular Progenitor Cells and Uterus Regeneration
title_full_unstemmed Endometrial Perivascular Progenitor Cells and Uterus Regeneration
title_short Endometrial Perivascular Progenitor Cells and Uterus Regeneration
title_sort endometrial perivascular progenitor cells and uterus regeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230145/
https://www.ncbi.nlm.nih.gov/pubmed/34071743
http://dx.doi.org/10.3390/jpm11060477
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