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Endometrial Perivascular Progenitor Cells and Uterus Regeneration
Ovarian steroid-regulated cyclical regeneration of the endometrium is crucial for endometrial receptivity and embryo implantation, and it is dependent on the dynamic remodeling of the endometrial vasculature. Perivascular cells, including pericytes surrounding capillaries and microvessels and advent...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230145/ https://www.ncbi.nlm.nih.gov/pubmed/34071743 http://dx.doi.org/10.3390/jpm11060477 |
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author | Li, Shiyuan Ding, Lijun |
author_facet | Li, Shiyuan Ding, Lijun |
author_sort | Li, Shiyuan |
collection | PubMed |
description | Ovarian steroid-regulated cyclical regeneration of the endometrium is crucial for endometrial receptivity and embryo implantation, and it is dependent on the dynamic remodeling of the endometrial vasculature. Perivascular cells, including pericytes surrounding capillaries and microvessels and adventitial cells located in the outermost layer of large vessels, show properties of mesenchymal stem cells, and they are thus promising candidates for uterine regeneration. In this review, we discuss the structure and functions of the endometrial blood vasculature and their roles in endometrial regeneration, the main biomarkers and characteristics of perivascular cells in the endometrium, and stem cell-based angiogenetic therapy for Asherman’s syndrome. |
format | Online Article Text |
id | pubmed-8230145 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82301452021-06-26 Endometrial Perivascular Progenitor Cells and Uterus Regeneration Li, Shiyuan Ding, Lijun J Pers Med Review Ovarian steroid-regulated cyclical regeneration of the endometrium is crucial for endometrial receptivity and embryo implantation, and it is dependent on the dynamic remodeling of the endometrial vasculature. Perivascular cells, including pericytes surrounding capillaries and microvessels and adventitial cells located in the outermost layer of large vessels, show properties of mesenchymal stem cells, and they are thus promising candidates for uterine regeneration. In this review, we discuss the structure and functions of the endometrial blood vasculature and their roles in endometrial regeneration, the main biomarkers and characteristics of perivascular cells in the endometrium, and stem cell-based angiogenetic therapy for Asherman’s syndrome. MDPI 2021-05-27 /pmc/articles/PMC8230145/ /pubmed/34071743 http://dx.doi.org/10.3390/jpm11060477 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Li, Shiyuan Ding, Lijun Endometrial Perivascular Progenitor Cells and Uterus Regeneration |
title | Endometrial Perivascular Progenitor Cells and Uterus Regeneration |
title_full | Endometrial Perivascular Progenitor Cells and Uterus Regeneration |
title_fullStr | Endometrial Perivascular Progenitor Cells and Uterus Regeneration |
title_full_unstemmed | Endometrial Perivascular Progenitor Cells and Uterus Regeneration |
title_short | Endometrial Perivascular Progenitor Cells and Uterus Regeneration |
title_sort | endometrial perivascular progenitor cells and uterus regeneration |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230145/ https://www.ncbi.nlm.nih.gov/pubmed/34071743 http://dx.doi.org/10.3390/jpm11060477 |
work_keys_str_mv | AT lishiyuan endometrialperivascularprogenitorcellsanduterusregeneration AT dinglijun endometrialperivascularprogenitorcellsanduterusregeneration |