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TCL1A, B Cell Regulation and Tolerance in Renal Transplantation
Despite much progress in the management of kidney transplantation, the need for life-long immunosuppressive therapies remains a major issue representing many risks for patients. Operational tolerance, defined as allograft acceptance without immunosuppression, has logically been subject to many inves...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230170/ https://www.ncbi.nlm.nih.gov/pubmed/34206047 http://dx.doi.org/10.3390/cells10061367 |
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author | Brinas, François Danger, Richard Brouard, Sophie |
author_facet | Brinas, François Danger, Richard Brouard, Sophie |
author_sort | Brinas, François |
collection | PubMed |
description | Despite much progress in the management of kidney transplantation, the need for life-long immunosuppressive therapies remains a major issue representing many risks for patients. Operational tolerance, defined as allograft acceptance without immunosuppression, has logically been subject to many investigations with the aim of a better understanding of post-transplantation mechanisms and potentially how it would be induced in patients. Among proposed biomarkers, T-cell Leukemia/Lymphoma protein 1A (TCL1A) has been observed as overexpressed in the peripheral blood of operational tolerant patients in several studies. TCL1A expression is restricted to early B cells, also increased in the blood of tolerant patients, and showing regulatory properties, notably through IL-10 secretion for some subsets. TCL1A has first been identified as an oncogene, overexpression of which is associated to the development of T and B cell cancer. TCL1A acts as a coactivator of the serine threonine kinase Akt and through other interactions favoring cell survival, growth, and proliferation. It has also been identified as interacting with others major actors involved in B cells differentiation and regulation, including IL-10 production. Herein, we reviewed known interactions and functions of TCL1A in B cells which could involve its potential role in the set up and maintenance of renal allograft tolerance. |
format | Online Article Text |
id | pubmed-8230170 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82301702021-06-26 TCL1A, B Cell Regulation and Tolerance in Renal Transplantation Brinas, François Danger, Richard Brouard, Sophie Cells Review Despite much progress in the management of kidney transplantation, the need for life-long immunosuppressive therapies remains a major issue representing many risks for patients. Operational tolerance, defined as allograft acceptance without immunosuppression, has logically been subject to many investigations with the aim of a better understanding of post-transplantation mechanisms and potentially how it would be induced in patients. Among proposed biomarkers, T-cell Leukemia/Lymphoma protein 1A (TCL1A) has been observed as overexpressed in the peripheral blood of operational tolerant patients in several studies. TCL1A expression is restricted to early B cells, also increased in the blood of tolerant patients, and showing regulatory properties, notably through IL-10 secretion for some subsets. TCL1A has first been identified as an oncogene, overexpression of which is associated to the development of T and B cell cancer. TCL1A acts as a coactivator of the serine threonine kinase Akt and through other interactions favoring cell survival, growth, and proliferation. It has also been identified as interacting with others major actors involved in B cells differentiation and regulation, including IL-10 production. Herein, we reviewed known interactions and functions of TCL1A in B cells which could involve its potential role in the set up and maintenance of renal allograft tolerance. MDPI 2021-06-01 /pmc/articles/PMC8230170/ /pubmed/34206047 http://dx.doi.org/10.3390/cells10061367 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Brinas, François Danger, Richard Brouard, Sophie TCL1A, B Cell Regulation and Tolerance in Renal Transplantation |
title | TCL1A, B Cell Regulation and Tolerance in Renal Transplantation |
title_full | TCL1A, B Cell Regulation and Tolerance in Renal Transplantation |
title_fullStr | TCL1A, B Cell Regulation and Tolerance in Renal Transplantation |
title_full_unstemmed | TCL1A, B Cell Regulation and Tolerance in Renal Transplantation |
title_short | TCL1A, B Cell Regulation and Tolerance in Renal Transplantation |
title_sort | tcl1a, b cell regulation and tolerance in renal transplantation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230170/ https://www.ncbi.nlm.nih.gov/pubmed/34206047 http://dx.doi.org/10.3390/cells10061367 |
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