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Regenerative Strategies in Cleft Palate: An Umbrella Review

(1) Background: Alveolar bone defects or decreased alveolar bone height and width may have different causes, such as cleft palate. Regenerative procedures in oro-dental defects are challenging due to anatomical factors and the distinct cell populations involved. The iliac crest bone graft remains th...

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Autores principales: Francisco, Inês, Paula, Anabela Baptista, Oliveiros, Bárbara, Fernandes, Maria Helena, Carrilho, Eunice, Marto, Carlos Miguel, Vale, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230219/
https://www.ncbi.nlm.nih.gov/pubmed/34205126
http://dx.doi.org/10.3390/bioengineering8060076
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author Francisco, Inês
Paula, Anabela Baptista
Oliveiros, Bárbara
Fernandes, Maria Helena
Carrilho, Eunice
Marto, Carlos Miguel
Vale, Francisco
author_facet Francisco, Inês
Paula, Anabela Baptista
Oliveiros, Bárbara
Fernandes, Maria Helena
Carrilho, Eunice
Marto, Carlos Miguel
Vale, Francisco
author_sort Francisco, Inês
collection PubMed
description (1) Background: Alveolar bone defects or decreased alveolar bone height and width may have different causes, such as cleft palate. Regenerative procedures in oro-dental defects are challenging due to anatomical factors and the distinct cell populations involved. The iliac crest bone graft remains the gold-standard for cleft palate closure. However, tissue regeneration approaches have been employed and their outcome reviewed, but no conclusions have been made about which one is the gold-standard. (2) Methods: this umbrella review aims to critically appraise the effectiveness of the current approaches in bone defects regeneration in non-syndromic patients with cleft palate. A search was performed in PubMed, Cochrane Library, Scopus, Web of Science and EMBASE databases. (3) Results: Systematic reviews of randomized and non-randomized controlled trials with or without meta-analysis were included. Nine articles were included in the qualitative analysis and five in the quantitative one. The included studies quality was evaluated with AMSTAR2. (4) Conclusions: The use of new regenerative strategies, such as bone morphogenic protein 2, appears to provide similar results regarding bone volume, filling, and height to the standard technique with the iliac crest bone graft.
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spelling pubmed-82302192021-06-26 Regenerative Strategies in Cleft Palate: An Umbrella Review Francisco, Inês Paula, Anabela Baptista Oliveiros, Bárbara Fernandes, Maria Helena Carrilho, Eunice Marto, Carlos Miguel Vale, Francisco Bioengineering (Basel) Review (1) Background: Alveolar bone defects or decreased alveolar bone height and width may have different causes, such as cleft palate. Regenerative procedures in oro-dental defects are challenging due to anatomical factors and the distinct cell populations involved. The iliac crest bone graft remains the gold-standard for cleft palate closure. However, tissue regeneration approaches have been employed and their outcome reviewed, but no conclusions have been made about which one is the gold-standard. (2) Methods: this umbrella review aims to critically appraise the effectiveness of the current approaches in bone defects regeneration in non-syndromic patients with cleft palate. A search was performed in PubMed, Cochrane Library, Scopus, Web of Science and EMBASE databases. (3) Results: Systematic reviews of randomized and non-randomized controlled trials with or without meta-analysis were included. Nine articles were included in the qualitative analysis and five in the quantitative one. The included studies quality was evaluated with AMSTAR2. (4) Conclusions: The use of new regenerative strategies, such as bone morphogenic protein 2, appears to provide similar results regarding bone volume, filling, and height to the standard technique with the iliac crest bone graft. MDPI 2021-06-03 /pmc/articles/PMC8230219/ /pubmed/34205126 http://dx.doi.org/10.3390/bioengineering8060076 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Francisco, Inês
Paula, Anabela Baptista
Oliveiros, Bárbara
Fernandes, Maria Helena
Carrilho, Eunice
Marto, Carlos Miguel
Vale, Francisco
Regenerative Strategies in Cleft Palate: An Umbrella Review
title Regenerative Strategies in Cleft Palate: An Umbrella Review
title_full Regenerative Strategies in Cleft Palate: An Umbrella Review
title_fullStr Regenerative Strategies in Cleft Palate: An Umbrella Review
title_full_unstemmed Regenerative Strategies in Cleft Palate: An Umbrella Review
title_short Regenerative Strategies in Cleft Palate: An Umbrella Review
title_sort regenerative strategies in cleft palate: an umbrella review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230219/
https://www.ncbi.nlm.nih.gov/pubmed/34205126
http://dx.doi.org/10.3390/bioengineering8060076
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