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Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies

Chronic hepatitis C virus (HCV) infections continue to be a major contributor to liver disease worldwide. HCV treatment has become highly effective, yet there are still no vaccines or prophylactic strategies available to prevent infection and allow effective management of the global HCV burden. Glyc...

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Autores principales: LeBlanc, Emmanuelle V., Kim, Youjin, Capicciotti, Chantelle J., Colpitts, Che C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230238/
https://www.ncbi.nlm.nih.gov/pubmed/34205894
http://dx.doi.org/10.3390/pathogens10060685
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author LeBlanc, Emmanuelle V.
Kim, Youjin
Capicciotti, Chantelle J.
Colpitts, Che C.
author_facet LeBlanc, Emmanuelle V.
Kim, Youjin
Capicciotti, Chantelle J.
Colpitts, Che C.
author_sort LeBlanc, Emmanuelle V.
collection PubMed
description Chronic hepatitis C virus (HCV) infections continue to be a major contributor to liver disease worldwide. HCV treatment has become highly effective, yet there are still no vaccines or prophylactic strategies available to prevent infection and allow effective management of the global HCV burden. Glycan-dependent interactions are crucial to many aspects of the highly complex HCV entry process, and also modulate immune evasion. This review provides an overview of the roles of viral and cellular glycans in HCV infection and highlights glycan-focused advances in the development of entry inhibitors and vaccines to effectively prevent HCV infection.
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spelling pubmed-82302382021-06-26 Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies LeBlanc, Emmanuelle V. Kim, Youjin Capicciotti, Chantelle J. Colpitts, Che C. Pathogens Review Chronic hepatitis C virus (HCV) infections continue to be a major contributor to liver disease worldwide. HCV treatment has become highly effective, yet there are still no vaccines or prophylactic strategies available to prevent infection and allow effective management of the global HCV burden. Glycan-dependent interactions are crucial to many aspects of the highly complex HCV entry process, and also modulate immune evasion. This review provides an overview of the roles of viral and cellular glycans in HCV infection and highlights glycan-focused advances in the development of entry inhibitors and vaccines to effectively prevent HCV infection. MDPI 2021-06-01 /pmc/articles/PMC8230238/ /pubmed/34205894 http://dx.doi.org/10.3390/pathogens10060685 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
LeBlanc, Emmanuelle V.
Kim, Youjin
Capicciotti, Chantelle J.
Colpitts, Che C.
Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies
title Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies
title_full Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies
title_fullStr Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies
title_full_unstemmed Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies
title_short Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies
title_sort hepatitis c virus glycan-dependent interactions and the potential for novel preventative strategies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230238/
https://www.ncbi.nlm.nih.gov/pubmed/34205894
http://dx.doi.org/10.3390/pathogens10060685
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