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Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies
Chronic hepatitis C virus (HCV) infections continue to be a major contributor to liver disease worldwide. HCV treatment has become highly effective, yet there are still no vaccines or prophylactic strategies available to prevent infection and allow effective management of the global HCV burden. Glyc...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230238/ https://www.ncbi.nlm.nih.gov/pubmed/34205894 http://dx.doi.org/10.3390/pathogens10060685 |
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author | LeBlanc, Emmanuelle V. Kim, Youjin Capicciotti, Chantelle J. Colpitts, Che C. |
author_facet | LeBlanc, Emmanuelle V. Kim, Youjin Capicciotti, Chantelle J. Colpitts, Che C. |
author_sort | LeBlanc, Emmanuelle V. |
collection | PubMed |
description | Chronic hepatitis C virus (HCV) infections continue to be a major contributor to liver disease worldwide. HCV treatment has become highly effective, yet there are still no vaccines or prophylactic strategies available to prevent infection and allow effective management of the global HCV burden. Glycan-dependent interactions are crucial to many aspects of the highly complex HCV entry process, and also modulate immune evasion. This review provides an overview of the roles of viral and cellular glycans in HCV infection and highlights glycan-focused advances in the development of entry inhibitors and vaccines to effectively prevent HCV infection. |
format | Online Article Text |
id | pubmed-8230238 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82302382021-06-26 Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies LeBlanc, Emmanuelle V. Kim, Youjin Capicciotti, Chantelle J. Colpitts, Che C. Pathogens Review Chronic hepatitis C virus (HCV) infections continue to be a major contributor to liver disease worldwide. HCV treatment has become highly effective, yet there are still no vaccines or prophylactic strategies available to prevent infection and allow effective management of the global HCV burden. Glycan-dependent interactions are crucial to many aspects of the highly complex HCV entry process, and also modulate immune evasion. This review provides an overview of the roles of viral and cellular glycans in HCV infection and highlights glycan-focused advances in the development of entry inhibitors and vaccines to effectively prevent HCV infection. MDPI 2021-06-01 /pmc/articles/PMC8230238/ /pubmed/34205894 http://dx.doi.org/10.3390/pathogens10060685 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review LeBlanc, Emmanuelle V. Kim, Youjin Capicciotti, Chantelle J. Colpitts, Che C. Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies |
title | Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies |
title_full | Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies |
title_fullStr | Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies |
title_full_unstemmed | Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies |
title_short | Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies |
title_sort | hepatitis c virus glycan-dependent interactions and the potential for novel preventative strategies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230238/ https://www.ncbi.nlm.nih.gov/pubmed/34205894 http://dx.doi.org/10.3390/pathogens10060685 |
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