Cargando…

Elucidating the Local Transmission Dynamics of Highly Pathogenic Avian Influenza H5N6 in the Republic of Korea by Integrating Phylogenetic Information

Highly pathogenic avian influenza (HPAI) virus is one of the most virulent and infectious pathogens of poultry. As a response to HPAI epidemics, veterinary authorities implement preemptive depopulation as a controlling strategy. However, mass culling within a uniform radius of the infection site can...

Descripción completa

Detalles Bibliográficos
Autores principales: Yoo, Dae-Sung, Chun, Byungchul, Min, Kyung-Duk, Lim, Jun-Sik, Moon, Oun-Kyoung, Lee, Kwang-Nyeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230294/
https://www.ncbi.nlm.nih.gov/pubmed/34199439
http://dx.doi.org/10.3390/pathogens10060691
_version_ 1783713174500933632
author Yoo, Dae-Sung
Chun, Byungchul
Min, Kyung-Duk
Lim, Jun-Sik
Moon, Oun-Kyoung
Lee, Kwang-Nyeong
author_facet Yoo, Dae-Sung
Chun, Byungchul
Min, Kyung-Duk
Lim, Jun-Sik
Moon, Oun-Kyoung
Lee, Kwang-Nyeong
author_sort Yoo, Dae-Sung
collection PubMed
description Highly pathogenic avian influenza (HPAI) virus is one of the most virulent and infectious pathogens of poultry. As a response to HPAI epidemics, veterinary authorities implement preemptive depopulation as a controlling strategy. However, mass culling within a uniform radius of the infection site can result in unnecessary depopulation. Therefore, it is useful to quantify the transmission distance from infected premises (IPs) before determining the optimal area for preemptive depopulation. Accordingly, we analyzed the transmission risk within spatiotemporal clusters of IPs using transmission kernel estimates derived from phylogenetic clustering information on 311 HPAI H5N6 IPs identified during the 2016–2017 epidemic, Republic of Korea. Subsequently, we explored the impact of varying the culling radius on the local transmission of HPAI given the transmission risk estimates. The domestic duck farm density was positively associated with higher transmissibility. Ring culling over a radius of 3 km may be effective for areas with high dense duck holdings, but this approach does not appear to significantly reduce the risk for local transmission in areas with chicken farms. This study provides the first estimation of the local transmission dynamics of HPAI in the Republic of Korea as well as insight into determining an effective ring culling radius.
format Online
Article
Text
id pubmed-8230294
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-82302942021-06-26 Elucidating the Local Transmission Dynamics of Highly Pathogenic Avian Influenza H5N6 in the Republic of Korea by Integrating Phylogenetic Information Yoo, Dae-Sung Chun, Byungchul Min, Kyung-Duk Lim, Jun-Sik Moon, Oun-Kyoung Lee, Kwang-Nyeong Pathogens Article Highly pathogenic avian influenza (HPAI) virus is one of the most virulent and infectious pathogens of poultry. As a response to HPAI epidemics, veterinary authorities implement preemptive depopulation as a controlling strategy. However, mass culling within a uniform radius of the infection site can result in unnecessary depopulation. Therefore, it is useful to quantify the transmission distance from infected premises (IPs) before determining the optimal area for preemptive depopulation. Accordingly, we analyzed the transmission risk within spatiotemporal clusters of IPs using transmission kernel estimates derived from phylogenetic clustering information on 311 HPAI H5N6 IPs identified during the 2016–2017 epidemic, Republic of Korea. Subsequently, we explored the impact of varying the culling radius on the local transmission of HPAI given the transmission risk estimates. The domestic duck farm density was positively associated with higher transmissibility. Ring culling over a radius of 3 km may be effective for areas with high dense duck holdings, but this approach does not appear to significantly reduce the risk for local transmission in areas with chicken farms. This study provides the first estimation of the local transmission dynamics of HPAI in the Republic of Korea as well as insight into determining an effective ring culling radius. MDPI 2021-06-02 /pmc/articles/PMC8230294/ /pubmed/34199439 http://dx.doi.org/10.3390/pathogens10060691 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yoo, Dae-Sung
Chun, Byungchul
Min, Kyung-Duk
Lim, Jun-Sik
Moon, Oun-Kyoung
Lee, Kwang-Nyeong
Elucidating the Local Transmission Dynamics of Highly Pathogenic Avian Influenza H5N6 in the Republic of Korea by Integrating Phylogenetic Information
title Elucidating the Local Transmission Dynamics of Highly Pathogenic Avian Influenza H5N6 in the Republic of Korea by Integrating Phylogenetic Information
title_full Elucidating the Local Transmission Dynamics of Highly Pathogenic Avian Influenza H5N6 in the Republic of Korea by Integrating Phylogenetic Information
title_fullStr Elucidating the Local Transmission Dynamics of Highly Pathogenic Avian Influenza H5N6 in the Republic of Korea by Integrating Phylogenetic Information
title_full_unstemmed Elucidating the Local Transmission Dynamics of Highly Pathogenic Avian Influenza H5N6 in the Republic of Korea by Integrating Phylogenetic Information
title_short Elucidating the Local Transmission Dynamics of Highly Pathogenic Avian Influenza H5N6 in the Republic of Korea by Integrating Phylogenetic Information
title_sort elucidating the local transmission dynamics of highly pathogenic avian influenza h5n6 in the republic of korea by integrating phylogenetic information
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230294/
https://www.ncbi.nlm.nih.gov/pubmed/34199439
http://dx.doi.org/10.3390/pathogens10060691
work_keys_str_mv AT yoodaesung elucidatingthelocaltransmissiondynamicsofhighlypathogenicavianinfluenzah5n6intherepublicofkoreabyintegratingphylogeneticinformation
AT chunbyungchul elucidatingthelocaltransmissiondynamicsofhighlypathogenicavianinfluenzah5n6intherepublicofkoreabyintegratingphylogeneticinformation
AT minkyungduk elucidatingthelocaltransmissiondynamicsofhighlypathogenicavianinfluenzah5n6intherepublicofkoreabyintegratingphylogeneticinformation
AT limjunsik elucidatingthelocaltransmissiondynamicsofhighlypathogenicavianinfluenzah5n6intherepublicofkoreabyintegratingphylogeneticinformation
AT moonounkyoung elucidatingthelocaltransmissiondynamicsofhighlypathogenicavianinfluenzah5n6intherepublicofkoreabyintegratingphylogeneticinformation
AT leekwangnyeong elucidatingthelocaltransmissiondynamicsofhighlypathogenicavianinfluenzah5n6intherepublicofkoreabyintegratingphylogeneticinformation