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Peptides and Peptidomimetics as Inhibitors of Enzymes Involved in Fibrillar Collagen Degradation

Collagen fibres degradation is a complex process involving a variety of enzymes. Fibrillar collagens, namely type I, II, and III, are the most widely spread collagens in human body, e.g., they are responsible for tissue fibrillar structure and skin elasticity. Nevertheless, the hyperactivity of fibr...

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Autores principales: Ledwoń, Patrycja, Papini, Anna Maria, Rovero, Paolo, Latajka, Rafal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230458/
https://www.ncbi.nlm.nih.gov/pubmed/34200889
http://dx.doi.org/10.3390/ma14123217
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author Ledwoń, Patrycja
Papini, Anna Maria
Rovero, Paolo
Latajka, Rafal
author_facet Ledwoń, Patrycja
Papini, Anna Maria
Rovero, Paolo
Latajka, Rafal
author_sort Ledwoń, Patrycja
collection PubMed
description Collagen fibres degradation is a complex process involving a variety of enzymes. Fibrillar collagens, namely type I, II, and III, are the most widely spread collagens in human body, e.g., they are responsible for tissue fibrillar structure and skin elasticity. Nevertheless, the hyperactivity of fibrotic process and collagen accumulation results with joints, bone, heart, lungs, kidneys or liver fibroses. Per contra, dysfunctional collagen turnover and its increased degradation leads to wound healing disruption, skin photoaging, and loss of firmness and elasticity. In this review we described the main enzymes participating in collagen degradation pathway, paying particular attention to enzymes degrading fibrillar collagen. Therefore, collagenases (MMP-1, -8, and -13), elastases, and cathepsins, together with their peptide and peptidomimetic inhibitors, are reviewed. This information, related to the design and synthesis of new inhibitors based on peptide structure, can be relevant for future research in the fields of chemistry, biology, medicine, and cosmeceuticals.
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spelling pubmed-82304582021-06-26 Peptides and Peptidomimetics as Inhibitors of Enzymes Involved in Fibrillar Collagen Degradation Ledwoń, Patrycja Papini, Anna Maria Rovero, Paolo Latajka, Rafal Materials (Basel) Review Collagen fibres degradation is a complex process involving a variety of enzymes. Fibrillar collagens, namely type I, II, and III, are the most widely spread collagens in human body, e.g., they are responsible for tissue fibrillar structure and skin elasticity. Nevertheless, the hyperactivity of fibrotic process and collagen accumulation results with joints, bone, heart, lungs, kidneys or liver fibroses. Per contra, dysfunctional collagen turnover and its increased degradation leads to wound healing disruption, skin photoaging, and loss of firmness and elasticity. In this review we described the main enzymes participating in collagen degradation pathway, paying particular attention to enzymes degrading fibrillar collagen. Therefore, collagenases (MMP-1, -8, and -13), elastases, and cathepsins, together with their peptide and peptidomimetic inhibitors, are reviewed. This information, related to the design and synthesis of new inhibitors based on peptide structure, can be relevant for future research in the fields of chemistry, biology, medicine, and cosmeceuticals. MDPI 2021-06-10 /pmc/articles/PMC8230458/ /pubmed/34200889 http://dx.doi.org/10.3390/ma14123217 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ledwoń, Patrycja
Papini, Anna Maria
Rovero, Paolo
Latajka, Rafal
Peptides and Peptidomimetics as Inhibitors of Enzymes Involved in Fibrillar Collagen Degradation
title Peptides and Peptidomimetics as Inhibitors of Enzymes Involved in Fibrillar Collagen Degradation
title_full Peptides and Peptidomimetics as Inhibitors of Enzymes Involved in Fibrillar Collagen Degradation
title_fullStr Peptides and Peptidomimetics as Inhibitors of Enzymes Involved in Fibrillar Collagen Degradation
title_full_unstemmed Peptides and Peptidomimetics as Inhibitors of Enzymes Involved in Fibrillar Collagen Degradation
title_short Peptides and Peptidomimetics as Inhibitors of Enzymes Involved in Fibrillar Collagen Degradation
title_sort peptides and peptidomimetics as inhibitors of enzymes involved in fibrillar collagen degradation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230458/
https://www.ncbi.nlm.nih.gov/pubmed/34200889
http://dx.doi.org/10.3390/ma14123217
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