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Homocysteine and Age-Related Central Nervous System Diseases: Role of Inflammation

Hyperhomocysteinemia (HHcy) is remarkably common among the aging population. The relation between HHcy and the development of neurodegenerative diseases, such as Alzheimer’s disease (AD) and eye diseases, and age-related macular degeneration (AMD) and diabetic retinopathy (DR) in elderly people, has...

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Autores principales: Tawfik, Amany, Elsherbiny, Nehal M., Zaidi, Yusra, Rajpurohit, Pragya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230490/
https://www.ncbi.nlm.nih.gov/pubmed/34200792
http://dx.doi.org/10.3390/ijms22126259
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author Tawfik, Amany
Elsherbiny, Nehal M.
Zaidi, Yusra
Rajpurohit, Pragya
author_facet Tawfik, Amany
Elsherbiny, Nehal M.
Zaidi, Yusra
Rajpurohit, Pragya
author_sort Tawfik, Amany
collection PubMed
description Hyperhomocysteinemia (HHcy) is remarkably common among the aging population. The relation between HHcy and the development of neurodegenerative diseases, such as Alzheimer’s disease (AD) and eye diseases, and age-related macular degeneration (AMD) and diabetic retinopathy (DR) in elderly people, has been established. Disruption of the blood barrier function of the brain and retina is one of the most important underlying mechanisms associated with HHcy-induced neurodegenerative and retinal disorders. Impairment of the barrier function triggers inflammatory events that worsen disease pathology. Studies have shown that AD patients also suffer from visual impairments. As an extension of the central nervous system, the retina has been suggested as a prominent site of AD pathology. This review highlights inflammation as a possible underlying mechanism of HHcy-induced barrier dysfunction and neurovascular injury in aging diseases accompanied by HHcy, focusing on AD.
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spelling pubmed-82304902021-06-26 Homocysteine and Age-Related Central Nervous System Diseases: Role of Inflammation Tawfik, Amany Elsherbiny, Nehal M. Zaidi, Yusra Rajpurohit, Pragya Int J Mol Sci Review Hyperhomocysteinemia (HHcy) is remarkably common among the aging population. The relation between HHcy and the development of neurodegenerative diseases, such as Alzheimer’s disease (AD) and eye diseases, and age-related macular degeneration (AMD) and diabetic retinopathy (DR) in elderly people, has been established. Disruption of the blood barrier function of the brain and retina is one of the most important underlying mechanisms associated with HHcy-induced neurodegenerative and retinal disorders. Impairment of the barrier function triggers inflammatory events that worsen disease pathology. Studies have shown that AD patients also suffer from visual impairments. As an extension of the central nervous system, the retina has been suggested as a prominent site of AD pathology. This review highlights inflammation as a possible underlying mechanism of HHcy-induced barrier dysfunction and neurovascular injury in aging diseases accompanied by HHcy, focusing on AD. MDPI 2021-06-10 /pmc/articles/PMC8230490/ /pubmed/34200792 http://dx.doi.org/10.3390/ijms22126259 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tawfik, Amany
Elsherbiny, Nehal M.
Zaidi, Yusra
Rajpurohit, Pragya
Homocysteine and Age-Related Central Nervous System Diseases: Role of Inflammation
title Homocysteine and Age-Related Central Nervous System Diseases: Role of Inflammation
title_full Homocysteine and Age-Related Central Nervous System Diseases: Role of Inflammation
title_fullStr Homocysteine and Age-Related Central Nervous System Diseases: Role of Inflammation
title_full_unstemmed Homocysteine and Age-Related Central Nervous System Diseases: Role of Inflammation
title_short Homocysteine and Age-Related Central Nervous System Diseases: Role of Inflammation
title_sort homocysteine and age-related central nervous system diseases: role of inflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230490/
https://www.ncbi.nlm.nih.gov/pubmed/34200792
http://dx.doi.org/10.3390/ijms22126259
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