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Homocysteine and Age-Related Central Nervous System Diseases: Role of Inflammation
Hyperhomocysteinemia (HHcy) is remarkably common among the aging population. The relation between HHcy and the development of neurodegenerative diseases, such as Alzheimer’s disease (AD) and eye diseases, and age-related macular degeneration (AMD) and diabetic retinopathy (DR) in elderly people, has...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230490/ https://www.ncbi.nlm.nih.gov/pubmed/34200792 http://dx.doi.org/10.3390/ijms22126259 |
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author | Tawfik, Amany Elsherbiny, Nehal M. Zaidi, Yusra Rajpurohit, Pragya |
author_facet | Tawfik, Amany Elsherbiny, Nehal M. Zaidi, Yusra Rajpurohit, Pragya |
author_sort | Tawfik, Amany |
collection | PubMed |
description | Hyperhomocysteinemia (HHcy) is remarkably common among the aging population. The relation between HHcy and the development of neurodegenerative diseases, such as Alzheimer’s disease (AD) and eye diseases, and age-related macular degeneration (AMD) and diabetic retinopathy (DR) in elderly people, has been established. Disruption of the blood barrier function of the brain and retina is one of the most important underlying mechanisms associated with HHcy-induced neurodegenerative and retinal disorders. Impairment of the barrier function triggers inflammatory events that worsen disease pathology. Studies have shown that AD patients also suffer from visual impairments. As an extension of the central nervous system, the retina has been suggested as a prominent site of AD pathology. This review highlights inflammation as a possible underlying mechanism of HHcy-induced barrier dysfunction and neurovascular injury in aging diseases accompanied by HHcy, focusing on AD. |
format | Online Article Text |
id | pubmed-8230490 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82304902021-06-26 Homocysteine and Age-Related Central Nervous System Diseases: Role of Inflammation Tawfik, Amany Elsherbiny, Nehal M. Zaidi, Yusra Rajpurohit, Pragya Int J Mol Sci Review Hyperhomocysteinemia (HHcy) is remarkably common among the aging population. The relation between HHcy and the development of neurodegenerative diseases, such as Alzheimer’s disease (AD) and eye diseases, and age-related macular degeneration (AMD) and diabetic retinopathy (DR) in elderly people, has been established. Disruption of the blood barrier function of the brain and retina is one of the most important underlying mechanisms associated with HHcy-induced neurodegenerative and retinal disorders. Impairment of the barrier function triggers inflammatory events that worsen disease pathology. Studies have shown that AD patients also suffer from visual impairments. As an extension of the central nervous system, the retina has been suggested as a prominent site of AD pathology. This review highlights inflammation as a possible underlying mechanism of HHcy-induced barrier dysfunction and neurovascular injury in aging diseases accompanied by HHcy, focusing on AD. MDPI 2021-06-10 /pmc/articles/PMC8230490/ /pubmed/34200792 http://dx.doi.org/10.3390/ijms22126259 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tawfik, Amany Elsherbiny, Nehal M. Zaidi, Yusra Rajpurohit, Pragya Homocysteine and Age-Related Central Nervous System Diseases: Role of Inflammation |
title | Homocysteine and Age-Related Central Nervous System Diseases: Role of Inflammation |
title_full | Homocysteine and Age-Related Central Nervous System Diseases: Role of Inflammation |
title_fullStr | Homocysteine and Age-Related Central Nervous System Diseases: Role of Inflammation |
title_full_unstemmed | Homocysteine and Age-Related Central Nervous System Diseases: Role of Inflammation |
title_short | Homocysteine and Age-Related Central Nervous System Diseases: Role of Inflammation |
title_sort | homocysteine and age-related central nervous system diseases: role of inflammation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230490/ https://www.ncbi.nlm.nih.gov/pubmed/34200792 http://dx.doi.org/10.3390/ijms22126259 |
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