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Bacterial Cellulose Membrane Containing Epilobium angustifolium L. Extract as a Promising Material for the Topical Delivery of Antioxidants to the Skin

Bacterial cellulose membranes (BCs) are becoming useful as a drug delivery system to the skin. However, there are very few reports on their application of plant substances to the skin. Komagataeibacter xylinus was used for the production of bacterial cellulose (BC). The BC containing 5% and 10% etha...

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Autores principales: Nowak, Anna, Ossowicz-Rupniewska, Paula, Rakoczy, Rafał, Konopacki, Maciej, Perużyńska, Magdalena, Droździk, Marek, Makuch, Edyta, Duchnik, Wiktoria, Kucharski, Łukasz, Wenelska, Karolina, Klimowicz, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230535/
https://www.ncbi.nlm.nih.gov/pubmed/34200927
http://dx.doi.org/10.3390/ijms22126269
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author Nowak, Anna
Ossowicz-Rupniewska, Paula
Rakoczy, Rafał
Konopacki, Maciej
Perużyńska, Magdalena
Droździk, Marek
Makuch, Edyta
Duchnik, Wiktoria
Kucharski, Łukasz
Wenelska, Karolina
Klimowicz, Adam
author_facet Nowak, Anna
Ossowicz-Rupniewska, Paula
Rakoczy, Rafał
Konopacki, Maciej
Perużyńska, Magdalena
Droździk, Marek
Makuch, Edyta
Duchnik, Wiktoria
Kucharski, Łukasz
Wenelska, Karolina
Klimowicz, Adam
author_sort Nowak, Anna
collection PubMed
description Bacterial cellulose membranes (BCs) are becoming useful as a drug delivery system to the skin. However, there are very few reports on their application of plant substances to the skin. Komagataeibacter xylinus was used for the production of bacterial cellulose (BC). The BC containing 5% and 10% ethanolic extract of Epilobium angustifolium (FEE) (BC-5%FEE and BC-10%FEE, respectively) were prepared. Their mechanical, structural, and antioxidant properties, as well as phenolic acid content, were evaluated. The bioavailability of BC-FESs using mouse L929 fibroblasts as model cells was tested. Moreover, In Vitro penetration through the pigskin of the selected phenolic acids contained in FEE and their accumulation in the skin after topical application of BC-FEEs was examined. The BC-FEEs were characterized by antioxidant activity. The BC-5% FEE showed relatively low toxicity to healthy mouse fibroblasts. Gallic acid (GA), chlorogenic acid (ChA), 3,4-dihydroxybenzoic acid (3,4-DHB), 4-hydroxybenzoic acid (4-HB), 3-hydroxybenzoic acid (3-HB), and caffeic acid (CA) found in FEE were also identified in the membranes. After topical application of the membranes to the pigskin penetration of some phenolic acid and other antioxidants through the skin as well as their accumulation in the skin was observed. The bacterial cellulose membrane loaded by plant extract may be an interesting solution for topical antioxidant delivery to the skin.
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spelling pubmed-82305352021-06-26 Bacterial Cellulose Membrane Containing Epilobium angustifolium L. Extract as a Promising Material for the Topical Delivery of Antioxidants to the Skin Nowak, Anna Ossowicz-Rupniewska, Paula Rakoczy, Rafał Konopacki, Maciej Perużyńska, Magdalena Droździk, Marek Makuch, Edyta Duchnik, Wiktoria Kucharski, Łukasz Wenelska, Karolina Klimowicz, Adam Int J Mol Sci Article Bacterial cellulose membranes (BCs) are becoming useful as a drug delivery system to the skin. However, there are very few reports on their application of plant substances to the skin. Komagataeibacter xylinus was used for the production of bacterial cellulose (BC). The BC containing 5% and 10% ethanolic extract of Epilobium angustifolium (FEE) (BC-5%FEE and BC-10%FEE, respectively) were prepared. Their mechanical, structural, and antioxidant properties, as well as phenolic acid content, were evaluated. The bioavailability of BC-FESs using mouse L929 fibroblasts as model cells was tested. Moreover, In Vitro penetration through the pigskin of the selected phenolic acids contained in FEE and their accumulation in the skin after topical application of BC-FEEs was examined. The BC-FEEs were characterized by antioxidant activity. The BC-5% FEE showed relatively low toxicity to healthy mouse fibroblasts. Gallic acid (GA), chlorogenic acid (ChA), 3,4-dihydroxybenzoic acid (3,4-DHB), 4-hydroxybenzoic acid (4-HB), 3-hydroxybenzoic acid (3-HB), and caffeic acid (CA) found in FEE were also identified in the membranes. After topical application of the membranes to the pigskin penetration of some phenolic acid and other antioxidants through the skin as well as their accumulation in the skin was observed. The bacterial cellulose membrane loaded by plant extract may be an interesting solution for topical antioxidant delivery to the skin. MDPI 2021-06-10 /pmc/articles/PMC8230535/ /pubmed/34200927 http://dx.doi.org/10.3390/ijms22126269 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nowak, Anna
Ossowicz-Rupniewska, Paula
Rakoczy, Rafał
Konopacki, Maciej
Perużyńska, Magdalena
Droździk, Marek
Makuch, Edyta
Duchnik, Wiktoria
Kucharski, Łukasz
Wenelska, Karolina
Klimowicz, Adam
Bacterial Cellulose Membrane Containing Epilobium angustifolium L. Extract as a Promising Material for the Topical Delivery of Antioxidants to the Skin
title Bacterial Cellulose Membrane Containing Epilobium angustifolium L. Extract as a Promising Material for the Topical Delivery of Antioxidants to the Skin
title_full Bacterial Cellulose Membrane Containing Epilobium angustifolium L. Extract as a Promising Material for the Topical Delivery of Antioxidants to the Skin
title_fullStr Bacterial Cellulose Membrane Containing Epilobium angustifolium L. Extract as a Promising Material for the Topical Delivery of Antioxidants to the Skin
title_full_unstemmed Bacterial Cellulose Membrane Containing Epilobium angustifolium L. Extract as a Promising Material for the Topical Delivery of Antioxidants to the Skin
title_short Bacterial Cellulose Membrane Containing Epilobium angustifolium L. Extract as a Promising Material for the Topical Delivery of Antioxidants to the Skin
title_sort bacterial cellulose membrane containing epilobium angustifolium l. extract as a promising material for the topical delivery of antioxidants to the skin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230535/
https://www.ncbi.nlm.nih.gov/pubmed/34200927
http://dx.doi.org/10.3390/ijms22126269
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