Cargando…

Augmenting the Immune Response against a Stabilized HIV-1 Clade C Envelope Trimer by Silica Nanoparticle Delivery

The delivery of HIV-1 envelope (Env) trimer-based immunogens on the surface of nanoparticles holds promise to promote immunogenicity with the aim of inducing a potent, durable and broad neutralizing antibody (bnAb) response. Towards that goal, we examined the covalent conjugation of Env to 100 nm an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Peterhoff, David, Thalhauser, Stefanie, Sobczak, Jan M., Mohsen, Mona O., Voigt, Christoph, Seifert, Nicole, Neckermann, Patrick, Hauser, Alexandra, Ding, Song, Sattentau, Quentin, Bachmann, Martin F., Breunig, Miriam, Wagner, Ralf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230641/ https://www.ncbi.nlm.nih.gov/pubmed/34208059 http://dx.doi.org/10.3390/vaccines9060642

Ejemplares similares

Stepwise Conformational Stabilization of a HIV-1 Clade C Consensus Envelope Trimer Immunogen Impacts the Profile of Vaccine-Induced Antibody Responses
por: Hauser, Alexandra, et al.
Publicado: (2021)

Envelope Glycoprotein Trimers as HIV-1 Vaccine Immunogens
por: Sattentau, Quentin J.
Publicado: (2013)

Stabilized HIV-1 envelope glycoprotein trimers for vaccine use
por: Medina-Ramírez, Max, et al.
Publicado: (2017)

Assessing immunogenicity barriers of the HIV-1 envelope trimer
por: Maliqi, Liridona, et al.
Publicado: (2023)

Interplay of diverse adjuvants and nanoparticle presentation of native-like HIV-1 envelope trimers
por: Sliepen, Kwinten, et al.
Publicado: (2021)

Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization
por: Turner, Hannah L., et al.
Publicado: (2021)

Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization
por: Turner, Hannah L., et al.
Publicado: (2021)

Antibodies from Rabbits Immunized with HIV-1 Clade B SOSIP Trimers Can Neutralize Multiple Clade B Viruses by Destabilizing the Envelope Glycoprotein
por: van Haaren, M. M., et al.
Publicado: (2021)

Chemical Cross-Linking Stabilizes Native-Like HIV-1 Envelope Glycoprotein Trimer Antigens
por: Schiffner, Torben, et al.
Publicado: (2015)

Author Correction: Interplay of diverse adjuvants and nanoparticle presentation of native-like HIV-1 envelope trimers
por: Sliepen, Kwinten, et al.
Publicado: (2021)

High thermostability improves neutralizing antibody responses induced by native-like HIV-1 envelope trimers
por: del Moral-Sánchez, Iván, et al.
Publicado: (2022)

Sequential and Simultaneous Immunization of Rabbits with HIV-1 Envelope Glycoprotein SOSIP.664 Trimers from Clades A, B and C
por: Klasse, P. J., et al.
Publicado: (2016)

Stabilization of a soluble, native-like trimeric form of an efficiently cleaved Indian HIV-1 clade C envelope glycoprotein
por: Ahmed, Shubbir, et al.
Publicado: (2017)

HIV-1-neutralizing antibody induced by simian adenovirus- and poxvirus MVA-vectored BG505 native-like envelope trimers
por: Capucci, Silvia, et al.
Publicado: (2017)

Phase I Randomised Clinical Trial of an HIV-1(CN54), Clade C, Trimeric Envelope Vaccine Candidate Delivered Vaginally
por: Lewis, David J., et al.
Publicado: (2011)

Potency and durability of T and B cell immune responses after homologous and heterologous vector delivery of a trimer-stabilized, membrane-displayed HIV-1 clade ConC Env protein
por: Perdiguero, Beatriz, et al.
Publicado: (2023)

Correction: HIV-1-neutralizing antibody induced by simian adenovirus- and poxvirus MVA-vectored BG505 native-like envelope trimers
por: Capucci, Silvia, et al.
Publicado: (2023)

Consistent elicitation of cross-clade HIV-neutralizing responses achieved in guinea pigs after fusion peptide priming by repetitive envelope trimer boosting
por: Cheng, Cheng, et al.
Publicado: (2019)

Improving the immunogenicity of HIV-1 envelope trimer vaccines
por: Sanders, Rogier W
Publicado: (2011)

Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics
por: Torrents de la Peña, Alba, et al.
Publicado: (2019)

Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core
por: Borst, Andrew J, et al.
Publicado: (2018)

Structural Mechanism of Trimeric HIV-1 Envelope Glycoprotein Activation
por: Tran, Erin E. H., et al.
Publicado: (2012)

Molecular architecture of the uncleaved HIV-1 envelope glycoprotein trimer
por: Mao, Youdong, et al.
Publicado: (2013)

Stabilized diverse HIV-1 envelope trimers for vaccine design
por: Wang, Qian, et al.
Publicado: (2020)

Intravaginal immunization using the recombinant HIV-1 clade-C trimeric envelope glycoprotein CN54gp140 formulated within lyophilized solid dosage forms
por: Donnelly, Louise, et al.
Publicado: (2011)

Subunit organization of the membrane-bound HIV-1 envelope glycoprotein trimer
por: Mao, Youdong, et al.
Publicado: (2012)

Effects of Adjuvants on HIV-1 Envelope Glycoprotein SOSIP Trimers In Vitro
por: Ozorowski, Gabriel, et al.
Publicado: (2018)

Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer
por: Cao, Liwei, et al.
Publicado: (2018)

Stabilizing HIV-1 envelope glycoprotein trimers to induce neutralizing antibodies
por: Torrents de la Peña, Alba, et al.
Publicado: (2018)

Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization
por: Torrents de la Peña, Alba, et al.
Publicado: (2017)

The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template
por: Andrabi, Raiees, et al.
Publicado: (2019)

Presentation of HIV-1 envelope glycoprotein trimers on diverse nanoparticle platforms
por: Brouwer, Philip J.M., et al.
Publicado: (2019)

Multiple conformations of trimeric spikes visualized on a non-enveloped virus
por: Zhang, Yinong, et al.
Publicado: (2022)

Soluble prefusion-closed HIV-envelope trimers with glycan-covered bases
por: Olia, Adam S., et al.
Publicado: (2023)

A New Approach to Produce HIV-1 Envelope Trimers: BOTH CLEAVAGE AND PROPER GLYCOSYLATION ARE ESSENTIAL TO GENERATE AUTHENTIC TRIMERS
por: AlSalmi, Wadad, et al.
Publicado: (2015)

Cryo-Electron Tomographic Structure of an Immunodeficiency Virus Envelope Complex In Situ
por: Zanetti, Giulia, et al.
Publicado: (2006)

Comprehensive Antigenic Map of a Cleaved Soluble HIV-1 Envelope Trimer
por: Derking, Ronald, et al.
Publicado: (2015)

Quaternary Interaction of the HIV-1 Envelope Trimer with CD4 and Neutralizing Antibodies
por: Liu, Qingbo, et al.
Publicado: (2021)

Composition and Antigenic Effects of Individual Glycan Sites of a Trimeric HIV-1 Envelope Glycoprotein
por: Behrens, Anna-Janina, et al.
Publicado: (2016)

Antibody responses after intravaginal immunisation with trimeric HIV-1(CN54) clade C gp140 in Carbopol gel are augmented by systemic priming or boosting with an adjuvanted formulation
por: Cranage, Martin P., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_c7prkeelfsbmfhjkcq4aga054q