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Prognostic Value of Cortisol Index of Endobiogeny in Acute Myocardial Infarction Patients

Background and Objectives: Serum cortisol has been extensively studied for its role during acute myocardial infarction (AMI). Reports have been inconsistent, with high and low serum cortisol associated with various clinical outcomes. Several publications claim to have developed methods to evaluate c...

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Autores principales: Braukyliene, Rima, Hedayat, Kamyar, Zajanckauskiene, Laura, Jurenas, Martynas, Unikas, Ramunas, Aldujeli, Ali, Petrokas, Osvaldas, Zabiela, Vytautas, Steponaviciute, Rasa, Vitkauskiene, Astra, Hedayat, Brigita, Simonyte, Sandrita, Lesauskaite, Vaiva, Lapraz, Jean Claude, Zaliaduonyte, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230642/
https://www.ncbi.nlm.nih.gov/pubmed/34208003
http://dx.doi.org/10.3390/medicina57060602
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author Braukyliene, Rima
Hedayat, Kamyar
Zajanckauskiene, Laura
Jurenas, Martynas
Unikas, Ramunas
Aldujeli, Ali
Petrokas, Osvaldas
Zabiela, Vytautas
Steponaviciute, Rasa
Vitkauskiene, Astra
Hedayat, Brigita
Simonyte, Sandrita
Lesauskaite, Vaiva
Lapraz, Jean Claude
Zaliaduonyte, Diana
author_facet Braukyliene, Rima
Hedayat, Kamyar
Zajanckauskiene, Laura
Jurenas, Martynas
Unikas, Ramunas
Aldujeli, Ali
Petrokas, Osvaldas
Zabiela, Vytautas
Steponaviciute, Rasa
Vitkauskiene, Astra
Hedayat, Brigita
Simonyte, Sandrita
Lesauskaite, Vaiva
Lapraz, Jean Claude
Zaliaduonyte, Diana
author_sort Braukyliene, Rima
collection PubMed
description Background and Objectives: Serum cortisol has been extensively studied for its role during acute myocardial infarction (AMI). Reports have been inconsistent, with high and low serum cortisol associated with various clinical outcomes. Several publications claim to have developed methods to evaluate cortisol activity by using elements of complete blood count with its differential. This study aims to compare the prognostic value of the cortisol index of Endobiogeny with serum cortisol in AMI patients, and to identify if the risk of mortality in AMI patients can be more precisely assessed by using both troponin I and cortisol index than troponin I alone. Materials and methods: This prospective study included 123 consecutive patients diagnosed with AMI. Diagnostic coronary angiography and revascularization was performed for all patients. Cortisol index was measured on admission, on discharge, and after 6 months. Two year follow-up for all patients was obtained. Results: Our study shows cortisol index peaks at 7–12 h after the onset of AMI, while serum cortisol peaked within 3 h from the onset of AMI. The cortisol index is elevated at admission, then significantly decreases at discharge; furthermore, the decline to its bottom most at 6 months is observed with mean values being constantly elevated. The cortisol index on admission correlated with 24-month mortality. We established combined cut-off values of cortisol index on admission > 100 and troponin I > 1.56 μg/las a prognosticator of poor outcomes for the 24-month period. Conclusions: The cortisol index derived from the global living systems theory of Endobiogeny is more predictive of mortality than serum cortisol. Moreover, a combined assessment of cortisol index and Troponin I during AMI offers more accurate risk stratification of mortality risk than troponin alone.
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spelling pubmed-82306422021-06-26 Prognostic Value of Cortisol Index of Endobiogeny in Acute Myocardial Infarction Patients Braukyliene, Rima Hedayat, Kamyar Zajanckauskiene, Laura Jurenas, Martynas Unikas, Ramunas Aldujeli, Ali Petrokas, Osvaldas Zabiela, Vytautas Steponaviciute, Rasa Vitkauskiene, Astra Hedayat, Brigita Simonyte, Sandrita Lesauskaite, Vaiva Lapraz, Jean Claude Zaliaduonyte, Diana Medicina (Kaunas) Article Background and Objectives: Serum cortisol has been extensively studied for its role during acute myocardial infarction (AMI). Reports have been inconsistent, with high and low serum cortisol associated with various clinical outcomes. Several publications claim to have developed methods to evaluate cortisol activity by using elements of complete blood count with its differential. This study aims to compare the prognostic value of the cortisol index of Endobiogeny with serum cortisol in AMI patients, and to identify if the risk of mortality in AMI patients can be more precisely assessed by using both troponin I and cortisol index than troponin I alone. Materials and methods: This prospective study included 123 consecutive patients diagnosed with AMI. Diagnostic coronary angiography and revascularization was performed for all patients. Cortisol index was measured on admission, on discharge, and after 6 months. Two year follow-up for all patients was obtained. Results: Our study shows cortisol index peaks at 7–12 h after the onset of AMI, while serum cortisol peaked within 3 h from the onset of AMI. The cortisol index is elevated at admission, then significantly decreases at discharge; furthermore, the decline to its bottom most at 6 months is observed with mean values being constantly elevated. The cortisol index on admission correlated with 24-month mortality. We established combined cut-off values of cortisol index on admission > 100 and troponin I > 1.56 μg/las a prognosticator of poor outcomes for the 24-month period. Conclusions: The cortisol index derived from the global living systems theory of Endobiogeny is more predictive of mortality than serum cortisol. Moreover, a combined assessment of cortisol index and Troponin I during AMI offers more accurate risk stratification of mortality risk than troponin alone. MDPI 2021-06-11 /pmc/articles/PMC8230642/ /pubmed/34208003 http://dx.doi.org/10.3390/medicina57060602 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Braukyliene, Rima
Hedayat, Kamyar
Zajanckauskiene, Laura
Jurenas, Martynas
Unikas, Ramunas
Aldujeli, Ali
Petrokas, Osvaldas
Zabiela, Vytautas
Steponaviciute, Rasa
Vitkauskiene, Astra
Hedayat, Brigita
Simonyte, Sandrita
Lesauskaite, Vaiva
Lapraz, Jean Claude
Zaliaduonyte, Diana
Prognostic Value of Cortisol Index of Endobiogeny in Acute Myocardial Infarction Patients
title Prognostic Value of Cortisol Index of Endobiogeny in Acute Myocardial Infarction Patients
title_full Prognostic Value of Cortisol Index of Endobiogeny in Acute Myocardial Infarction Patients
title_fullStr Prognostic Value of Cortisol Index of Endobiogeny in Acute Myocardial Infarction Patients
title_full_unstemmed Prognostic Value of Cortisol Index of Endobiogeny in Acute Myocardial Infarction Patients
title_short Prognostic Value of Cortisol Index of Endobiogeny in Acute Myocardial Infarction Patients
title_sort prognostic value of cortisol index of endobiogeny in acute myocardial infarction patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230642/
https://www.ncbi.nlm.nih.gov/pubmed/34208003
http://dx.doi.org/10.3390/medicina57060602
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