Targeting the NAD Salvage Synthesis Pathway as a Novel Therapeutic Strategy for Osteosarcomas with Low NAPRT Expression

For osteosarcoma (OS), the most common primary malignant bone tumor, overall survival has hardly improved over the last four decades. Especially for metastatic OS, novel therapeutic targets are urgently needed. A hallmark of cancer is aberrant metabolism, which justifies targeting metabolic pathways...

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Detalles Bibliográficos
Autores principales: Franceschini, Natasja, Oosting, Jan, Tamsma, Maud, Niessen, Bertine, Bruijn, Inge Briaire-de, van den Akker, Brendy, Kruisselbrink, Alwine B., Palubeckaitė, Ieva, Bovée, Judith V. M. G., Cleton-Jansen, Anne-Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230647/
https://www.ncbi.nlm.nih.gov/pubmed/34200964
http://dx.doi.org/10.3390/ijms22126273

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