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Endothelial Dysfunction and Neutrophil Degranulation as Central Events in Sepsis Physiopathology
Sepsis is a major health problem worldwide. It is a time-dependent disease, with a high rate of morbidity and mortality. In this sense, an early diagnosis is essential to reduce these rates. The progressive increase of both the incidence and prevalence of sepsis has translated into a significant soc...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230689/ https://www.ncbi.nlm.nih.gov/pubmed/34200950 http://dx.doi.org/10.3390/ijms22126272 |
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author | Martín-Fernández, Marta Tamayo-Velasco, Álvaro Aller, Rocío Gonzalo-Benito, Hugo Martínez-Paz, Pedro Tamayo, Eduardo |
author_facet | Martín-Fernández, Marta Tamayo-Velasco, Álvaro Aller, Rocío Gonzalo-Benito, Hugo Martínez-Paz, Pedro Tamayo, Eduardo |
author_sort | Martín-Fernández, Marta |
collection | PubMed |
description | Sepsis is a major health problem worldwide. It is a time-dependent disease, with a high rate of morbidity and mortality. In this sense, an early diagnosis is essential to reduce these rates. The progressive increase of both the incidence and prevalence of sepsis has translated into a significant socioeconomic burden for health systems. Currently, it is the leading cause of noncoronary mortality worldwide and represents one of the most prevalent pathologies both in hospital emergency services and in intensive care units. In this article, we review the role of both endothelial dysfunction and neutrophil dysregulation in the physiopathology of this disease. The lack of a key symptom in sepsis makes it difficult to obtain a quick and accurate diagnosis of this condition. Thus, it is essential to have fast and reliable diagnostic tools. In this sense, the use of biomarkers can be a very important alternative when it comes to achieving these goals. Both new biomarkers and treatments related to endothelial dysfunction and neutrophil dysregulation deserve to be further investigated in order to open new venues for the diagnosis, treatment and prognosis of sepsis. |
format | Online Article Text |
id | pubmed-8230689 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82306892021-06-26 Endothelial Dysfunction and Neutrophil Degranulation as Central Events in Sepsis Physiopathology Martín-Fernández, Marta Tamayo-Velasco, Álvaro Aller, Rocío Gonzalo-Benito, Hugo Martínez-Paz, Pedro Tamayo, Eduardo Int J Mol Sci Review Sepsis is a major health problem worldwide. It is a time-dependent disease, with a high rate of morbidity and mortality. In this sense, an early diagnosis is essential to reduce these rates. The progressive increase of both the incidence and prevalence of sepsis has translated into a significant socioeconomic burden for health systems. Currently, it is the leading cause of noncoronary mortality worldwide and represents one of the most prevalent pathologies both in hospital emergency services and in intensive care units. In this article, we review the role of both endothelial dysfunction and neutrophil dysregulation in the physiopathology of this disease. The lack of a key symptom in sepsis makes it difficult to obtain a quick and accurate diagnosis of this condition. Thus, it is essential to have fast and reliable diagnostic tools. In this sense, the use of biomarkers can be a very important alternative when it comes to achieving these goals. Both new biomarkers and treatments related to endothelial dysfunction and neutrophil dysregulation deserve to be further investigated in order to open new venues for the diagnosis, treatment and prognosis of sepsis. MDPI 2021-06-10 /pmc/articles/PMC8230689/ /pubmed/34200950 http://dx.doi.org/10.3390/ijms22126272 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Martín-Fernández, Marta Tamayo-Velasco, Álvaro Aller, Rocío Gonzalo-Benito, Hugo Martínez-Paz, Pedro Tamayo, Eduardo Endothelial Dysfunction and Neutrophil Degranulation as Central Events in Sepsis Physiopathology |
title | Endothelial Dysfunction and Neutrophil Degranulation as Central Events in Sepsis Physiopathology |
title_full | Endothelial Dysfunction and Neutrophil Degranulation as Central Events in Sepsis Physiopathology |
title_fullStr | Endothelial Dysfunction and Neutrophil Degranulation as Central Events in Sepsis Physiopathology |
title_full_unstemmed | Endothelial Dysfunction and Neutrophil Degranulation as Central Events in Sepsis Physiopathology |
title_short | Endothelial Dysfunction and Neutrophil Degranulation as Central Events in Sepsis Physiopathology |
title_sort | endothelial dysfunction and neutrophil degranulation as central events in sepsis physiopathology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230689/ https://www.ncbi.nlm.nih.gov/pubmed/34200950 http://dx.doi.org/10.3390/ijms22126272 |
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