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Safety, Fear and Neuromuscular Responses after a Resisted Knee Extension Performed to Failure in Patients with Severe Haemophilia

Background: low–moderate intensity strength training to failure increases strength and muscle hypertrophy in healthy people. However, no study assessed the safety and neuromuscular response of training to failure in people with severe haemophilia (PWH). The purpose of the study was to analyse neurom...

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Autores principales: Calatayud, Joaquín, Martín-Cuesta, Jonathan, Carrasco, Juan J., Pérez-Alenda, Sofía, Cruz-Montecinos, Carlos, Andersen, Lars L., Querol-Giner, Felipe, Casaña, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230803/
https://www.ncbi.nlm.nih.gov/pubmed/34208148
http://dx.doi.org/10.3390/jcm10122587
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author Calatayud, Joaquín
Martín-Cuesta, Jonathan
Carrasco, Juan J.
Pérez-Alenda, Sofía
Cruz-Montecinos, Carlos
Andersen, Lars L.
Querol-Giner, Felipe
Casaña, José
author_facet Calatayud, Joaquín
Martín-Cuesta, Jonathan
Carrasco, Juan J.
Pérez-Alenda, Sofía
Cruz-Montecinos, Carlos
Andersen, Lars L.
Querol-Giner, Felipe
Casaña, José
author_sort Calatayud, Joaquín
collection PubMed
description Background: low–moderate intensity strength training to failure increases strength and muscle hypertrophy in healthy people. However, no study assessed the safety and neuromuscular response of training to failure in people with severe haemophilia (PWH). The purpose of the study was to analyse neuromuscular responses, fear of movement, and possible adverse effects in PWH, after knee extensions to failure. Methods: twelve severe PWH in prophylactic treatment performed knee extensions until failure at an intensity of five on the Borg CR10 scale. Normalised values of amplitude (nRMS) and neuromuscular fatigue were determined using surface electromyography for the rectus femoris, vastus medialis, and vastus lateralis. After the exercise, participants were asked about their perceived change in fear of movement, and to report any possible adverse effects. Results: Patients reported no adverse effects or increased fear. The nRMS was maximal for all the muscles before failure, the median frequency decreased, and wavelet index increased during the repetitions. The vastus lateralis demonstrated a higher maximum nRMS threshold and earlier fatigue, albeit with a lower and more progressive overall fatigue. Conclusions: severe PWH with adequate prophylactic treatment can perform knee extensions to task failure using a moderate intensity, without increasing fear of movement, or adverse effects.
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spelling pubmed-82308032021-06-26 Safety, Fear and Neuromuscular Responses after a Resisted Knee Extension Performed to Failure in Patients with Severe Haemophilia Calatayud, Joaquín Martín-Cuesta, Jonathan Carrasco, Juan J. Pérez-Alenda, Sofía Cruz-Montecinos, Carlos Andersen, Lars L. Querol-Giner, Felipe Casaña, José J Clin Med Article Background: low–moderate intensity strength training to failure increases strength and muscle hypertrophy in healthy people. However, no study assessed the safety and neuromuscular response of training to failure in people with severe haemophilia (PWH). The purpose of the study was to analyse neuromuscular responses, fear of movement, and possible adverse effects in PWH, after knee extensions to failure. Methods: twelve severe PWH in prophylactic treatment performed knee extensions until failure at an intensity of five on the Borg CR10 scale. Normalised values of amplitude (nRMS) and neuromuscular fatigue were determined using surface electromyography for the rectus femoris, vastus medialis, and vastus lateralis. After the exercise, participants were asked about their perceived change in fear of movement, and to report any possible adverse effects. Results: Patients reported no adverse effects or increased fear. The nRMS was maximal for all the muscles before failure, the median frequency decreased, and wavelet index increased during the repetitions. The vastus lateralis demonstrated a higher maximum nRMS threshold and earlier fatigue, albeit with a lower and more progressive overall fatigue. Conclusions: severe PWH with adequate prophylactic treatment can perform knee extensions to task failure using a moderate intensity, without increasing fear of movement, or adverse effects. MDPI 2021-06-11 /pmc/articles/PMC8230803/ /pubmed/34208148 http://dx.doi.org/10.3390/jcm10122587 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Calatayud, Joaquín
Martín-Cuesta, Jonathan
Carrasco, Juan J.
Pérez-Alenda, Sofía
Cruz-Montecinos, Carlos
Andersen, Lars L.
Querol-Giner, Felipe
Casaña, José
Safety, Fear and Neuromuscular Responses after a Resisted Knee Extension Performed to Failure in Patients with Severe Haemophilia
title Safety, Fear and Neuromuscular Responses after a Resisted Knee Extension Performed to Failure in Patients with Severe Haemophilia
title_full Safety, Fear and Neuromuscular Responses after a Resisted Knee Extension Performed to Failure in Patients with Severe Haemophilia
title_fullStr Safety, Fear and Neuromuscular Responses after a Resisted Knee Extension Performed to Failure in Patients with Severe Haemophilia
title_full_unstemmed Safety, Fear and Neuromuscular Responses after a Resisted Knee Extension Performed to Failure in Patients with Severe Haemophilia
title_short Safety, Fear and Neuromuscular Responses after a Resisted Knee Extension Performed to Failure in Patients with Severe Haemophilia
title_sort safety, fear and neuromuscular responses after a resisted knee extension performed to failure in patients with severe haemophilia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230803/
https://www.ncbi.nlm.nih.gov/pubmed/34208148
http://dx.doi.org/10.3390/jcm10122587
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