Cargando…
Maternal Vitamin D and Newborn Telomere Length
Nutrition is important during pregnancy for offspring health. Gestational vitamin D intake may prevent several adverse outcomes and might have an influence on offspring telomere length (TL). In this study, we want to assess the association between maternal vitamin D intake during pregnancy and newbo...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230815/ https://www.ncbi.nlm.nih.gov/pubmed/34208129 http://dx.doi.org/10.3390/nu13062012 |
_version_ | 1783713298836881408 |
---|---|
author | Daneels, Lisa Martens, Dries S. Arredouani, Soumia Billen, Jaak Koppen, Gudrun Devlieger, Roland Nawrot, Tim S. Ghosh, Manosij Godderis, Lode Pauwels, Sara |
author_facet | Daneels, Lisa Martens, Dries S. Arredouani, Soumia Billen, Jaak Koppen, Gudrun Devlieger, Roland Nawrot, Tim S. Ghosh, Manosij Godderis, Lode Pauwels, Sara |
author_sort | Daneels, Lisa |
collection | PubMed |
description | Nutrition is important during pregnancy for offspring health. Gestational vitamin D intake may prevent several adverse outcomes and might have an influence on offspring telomere length (TL). In this study, we want to assess the association between maternal vitamin D intake during pregnancy and newborn TL, as reflected by cord blood TL. We studied mother–child pairs enrolled in the Maternal Nutrition and Offspring’s Epigenome (MANOE) cohort, Leuven, Belgium. To calculate the dietary vitamin D intake, 108 women were asked to keep track of their diet using the seven-day estimated diet record (EDR) method. TL was assessed in 108 cord blood using a quantitative real-time PCR method. In each trimester of pregnancy, maternal serum 25-hydroxyvitamin D (25-OHD) concentration was measured. We observed a positive association (β = 0.009, p-value = 0.036) between newborn average relative TL and maternal vitamin D intake (diet + supplement) during the first trimester. In contrast, we found no association between average relative TL of the newborn and mean maternal serum 25-OHD concentrations during pregnancy. To conclude, vitamin D intake (diet + supplements), specifically during the first trimester of pregnancy, is an important factor associated with TL at birth. |
format | Online Article Text |
id | pubmed-8230815 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82308152021-06-26 Maternal Vitamin D and Newborn Telomere Length Daneels, Lisa Martens, Dries S. Arredouani, Soumia Billen, Jaak Koppen, Gudrun Devlieger, Roland Nawrot, Tim S. Ghosh, Manosij Godderis, Lode Pauwels, Sara Nutrients Article Nutrition is important during pregnancy for offspring health. Gestational vitamin D intake may prevent several adverse outcomes and might have an influence on offspring telomere length (TL). In this study, we want to assess the association between maternal vitamin D intake during pregnancy and newborn TL, as reflected by cord blood TL. We studied mother–child pairs enrolled in the Maternal Nutrition and Offspring’s Epigenome (MANOE) cohort, Leuven, Belgium. To calculate the dietary vitamin D intake, 108 women were asked to keep track of their diet using the seven-day estimated diet record (EDR) method. TL was assessed in 108 cord blood using a quantitative real-time PCR method. In each trimester of pregnancy, maternal serum 25-hydroxyvitamin D (25-OHD) concentration was measured. We observed a positive association (β = 0.009, p-value = 0.036) between newborn average relative TL and maternal vitamin D intake (diet + supplement) during the first trimester. In contrast, we found no association between average relative TL of the newborn and mean maternal serum 25-OHD concentrations during pregnancy. To conclude, vitamin D intake (diet + supplements), specifically during the first trimester of pregnancy, is an important factor associated with TL at birth. MDPI 2021-06-11 /pmc/articles/PMC8230815/ /pubmed/34208129 http://dx.doi.org/10.3390/nu13062012 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Daneels, Lisa Martens, Dries S. Arredouani, Soumia Billen, Jaak Koppen, Gudrun Devlieger, Roland Nawrot, Tim S. Ghosh, Manosij Godderis, Lode Pauwels, Sara Maternal Vitamin D and Newborn Telomere Length |
title | Maternal Vitamin D and Newborn Telomere Length |
title_full | Maternal Vitamin D and Newborn Telomere Length |
title_fullStr | Maternal Vitamin D and Newborn Telomere Length |
title_full_unstemmed | Maternal Vitamin D and Newborn Telomere Length |
title_short | Maternal Vitamin D and Newborn Telomere Length |
title_sort | maternal vitamin d and newborn telomere length |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230815/ https://www.ncbi.nlm.nih.gov/pubmed/34208129 http://dx.doi.org/10.3390/nu13062012 |
work_keys_str_mv | AT daneelslisa maternalvitamindandnewborntelomerelength AT martensdriess maternalvitamindandnewborntelomerelength AT arredouanisoumia maternalvitamindandnewborntelomerelength AT billenjaak maternalvitamindandnewborntelomerelength AT koppengudrun maternalvitamindandnewborntelomerelength AT devliegerroland maternalvitamindandnewborntelomerelength AT nawrottims maternalvitamindandnewborntelomerelength AT ghoshmanosij maternalvitamindandnewborntelomerelength AT godderislode maternalvitamindandnewborntelomerelength AT pauwelssara maternalvitamindandnewborntelomerelength |