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Maternal Vitamin D and Newborn Telomere Length

Nutrition is important during pregnancy for offspring health. Gestational vitamin D intake may prevent several adverse outcomes and might have an influence on offspring telomere length (TL). In this study, we want to assess the association between maternal vitamin D intake during pregnancy and newbo...

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Autores principales: Daneels, Lisa, Martens, Dries S., Arredouani, Soumia, Billen, Jaak, Koppen, Gudrun, Devlieger, Roland, Nawrot, Tim S., Ghosh, Manosij, Godderis, Lode, Pauwels, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230815/
https://www.ncbi.nlm.nih.gov/pubmed/34208129
http://dx.doi.org/10.3390/nu13062012
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author Daneels, Lisa
Martens, Dries S.
Arredouani, Soumia
Billen, Jaak
Koppen, Gudrun
Devlieger, Roland
Nawrot, Tim S.
Ghosh, Manosij
Godderis, Lode
Pauwels, Sara
author_facet Daneels, Lisa
Martens, Dries S.
Arredouani, Soumia
Billen, Jaak
Koppen, Gudrun
Devlieger, Roland
Nawrot, Tim S.
Ghosh, Manosij
Godderis, Lode
Pauwels, Sara
author_sort Daneels, Lisa
collection PubMed
description Nutrition is important during pregnancy for offspring health. Gestational vitamin D intake may prevent several adverse outcomes and might have an influence on offspring telomere length (TL). In this study, we want to assess the association between maternal vitamin D intake during pregnancy and newborn TL, as reflected by cord blood TL. We studied mother–child pairs enrolled in the Maternal Nutrition and Offspring’s Epigenome (MANOE) cohort, Leuven, Belgium. To calculate the dietary vitamin D intake, 108 women were asked to keep track of their diet using the seven-day estimated diet record (EDR) method. TL was assessed in 108 cord blood using a quantitative real-time PCR method. In each trimester of pregnancy, maternal serum 25-hydroxyvitamin D (25-OHD) concentration was measured. We observed a positive association (β = 0.009, p-value = 0.036) between newborn average relative TL and maternal vitamin D intake (diet + supplement) during the first trimester. In contrast, we found no association between average relative TL of the newborn and mean maternal serum 25-OHD concentrations during pregnancy. To conclude, vitamin D intake (diet + supplements), specifically during the first trimester of pregnancy, is an important factor associated with TL at birth.
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spelling pubmed-82308152021-06-26 Maternal Vitamin D and Newborn Telomere Length Daneels, Lisa Martens, Dries S. Arredouani, Soumia Billen, Jaak Koppen, Gudrun Devlieger, Roland Nawrot, Tim S. Ghosh, Manosij Godderis, Lode Pauwels, Sara Nutrients Article Nutrition is important during pregnancy for offspring health. Gestational vitamin D intake may prevent several adverse outcomes and might have an influence on offspring telomere length (TL). In this study, we want to assess the association between maternal vitamin D intake during pregnancy and newborn TL, as reflected by cord blood TL. We studied mother–child pairs enrolled in the Maternal Nutrition and Offspring’s Epigenome (MANOE) cohort, Leuven, Belgium. To calculate the dietary vitamin D intake, 108 women were asked to keep track of their diet using the seven-day estimated diet record (EDR) method. TL was assessed in 108 cord blood using a quantitative real-time PCR method. In each trimester of pregnancy, maternal serum 25-hydroxyvitamin D (25-OHD) concentration was measured. We observed a positive association (β = 0.009, p-value = 0.036) between newborn average relative TL and maternal vitamin D intake (diet + supplement) during the first trimester. In contrast, we found no association between average relative TL of the newborn and mean maternal serum 25-OHD concentrations during pregnancy. To conclude, vitamin D intake (diet + supplements), specifically during the first trimester of pregnancy, is an important factor associated with TL at birth. MDPI 2021-06-11 /pmc/articles/PMC8230815/ /pubmed/34208129 http://dx.doi.org/10.3390/nu13062012 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Daneels, Lisa
Martens, Dries S.
Arredouani, Soumia
Billen, Jaak
Koppen, Gudrun
Devlieger, Roland
Nawrot, Tim S.
Ghosh, Manosij
Godderis, Lode
Pauwels, Sara
Maternal Vitamin D and Newborn Telomere Length
title Maternal Vitamin D and Newborn Telomere Length
title_full Maternal Vitamin D and Newborn Telomere Length
title_fullStr Maternal Vitamin D and Newborn Telomere Length
title_full_unstemmed Maternal Vitamin D and Newborn Telomere Length
title_short Maternal Vitamin D and Newborn Telomere Length
title_sort maternal vitamin d and newborn telomere length
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230815/
https://www.ncbi.nlm.nih.gov/pubmed/34208129
http://dx.doi.org/10.3390/nu13062012
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