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Donnan Potential across the Outer Membrane of Gram-Negative Bacteria and Its Effect on the Permeability of Antibiotics

The cell envelope structure of Gram-negative bacteria is unique, composed of two lipid bilayer membranes and an aqueous periplasmic space sandwiched in between. The outer membrane constitutes an extra barrier to limit the exchange of molecules between the cells and the exterior environment. Donnan p...

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Detalles Bibliográficos
Autores principales: Alegun, Olaniyi, Pandeya, Ankit, Cui, Jian, Ojo, Isoiza, Wei, Yinan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230823/
https://www.ncbi.nlm.nih.gov/pubmed/34208097
http://dx.doi.org/10.3390/antibiotics10060701
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author Alegun, Olaniyi
Pandeya, Ankit
Cui, Jian
Ojo, Isoiza
Wei, Yinan
author_facet Alegun, Olaniyi
Pandeya, Ankit
Cui, Jian
Ojo, Isoiza
Wei, Yinan
author_sort Alegun, Olaniyi
collection PubMed
description The cell envelope structure of Gram-negative bacteria is unique, composed of two lipid bilayer membranes and an aqueous periplasmic space sandwiched in between. The outer membrane constitutes an extra barrier to limit the exchange of molecules between the cells and the exterior environment. Donnan potential is a membrane potential across the outer membrane, resulted from the selective permeability of the membrane, which plays a pivotal role in the permeability of many antibiotics. In this review, we discussed factors that affect the intensity of the Donnan potential, including the osmotic strength and pH of the external media, the osmoregulated periplasmic glucans trapped in the periplasmic space, and the displacement of cell surface charges. The focus of our discussion is the impact of Donnan potential on the cellular permeability of selected antibiotics including fluoroquinolones, tetracyclines, β-lactams, and trimethoprim.
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spelling pubmed-82308232021-06-26 Donnan Potential across the Outer Membrane of Gram-Negative Bacteria and Its Effect on the Permeability of Antibiotics Alegun, Olaniyi Pandeya, Ankit Cui, Jian Ojo, Isoiza Wei, Yinan Antibiotics (Basel) Review The cell envelope structure of Gram-negative bacteria is unique, composed of two lipid bilayer membranes and an aqueous periplasmic space sandwiched in between. The outer membrane constitutes an extra barrier to limit the exchange of molecules between the cells and the exterior environment. Donnan potential is a membrane potential across the outer membrane, resulted from the selective permeability of the membrane, which plays a pivotal role in the permeability of many antibiotics. In this review, we discussed factors that affect the intensity of the Donnan potential, including the osmotic strength and pH of the external media, the osmoregulated periplasmic glucans trapped in the periplasmic space, and the displacement of cell surface charges. The focus of our discussion is the impact of Donnan potential on the cellular permeability of selected antibiotics including fluoroquinolones, tetracyclines, β-lactams, and trimethoprim. MDPI 2021-06-11 /pmc/articles/PMC8230823/ /pubmed/34208097 http://dx.doi.org/10.3390/antibiotics10060701 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Alegun, Olaniyi
Pandeya, Ankit
Cui, Jian
Ojo, Isoiza
Wei, Yinan
Donnan Potential across the Outer Membrane of Gram-Negative Bacteria and Its Effect on the Permeability of Antibiotics
title Donnan Potential across the Outer Membrane of Gram-Negative Bacteria and Its Effect on the Permeability of Antibiotics
title_full Donnan Potential across the Outer Membrane of Gram-Negative Bacteria and Its Effect on the Permeability of Antibiotics
title_fullStr Donnan Potential across the Outer Membrane of Gram-Negative Bacteria and Its Effect on the Permeability of Antibiotics
title_full_unstemmed Donnan Potential across the Outer Membrane of Gram-Negative Bacteria and Its Effect on the Permeability of Antibiotics
title_short Donnan Potential across the Outer Membrane of Gram-Negative Bacteria and Its Effect on the Permeability of Antibiotics
title_sort donnan potential across the outer membrane of gram-negative bacteria and its effect on the permeability of antibiotics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230823/
https://www.ncbi.nlm.nih.gov/pubmed/34208097
http://dx.doi.org/10.3390/antibiotics10060701
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