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Formation of Self-Assembled Mesophases During Lipid Digestion
Lipids play an important role in regulating bodily functions and providing a source of energy. Lipids enter the body primarily in the form of triglycerides in our diet. The gastrointestinal digestion of certain types of lipids has been shown to promote the self-assembly of lipid digestion products i...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231029/ https://www.ncbi.nlm.nih.gov/pubmed/34178984 http://dx.doi.org/10.3389/fcell.2021.657886 |
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author | Pham, Anna C. Clulow, Andrew J. Boyd, Ben J. |
author_facet | Pham, Anna C. Clulow, Andrew J. Boyd, Ben J. |
author_sort | Pham, Anna C. |
collection | PubMed |
description | Lipids play an important role in regulating bodily functions and providing a source of energy. Lipids enter the body primarily in the form of triglycerides in our diet. The gastrointestinal digestion of certain types of lipids has been shown to promote the self-assembly of lipid digestion products into highly ordered colloidal structures. The formation of these ordered colloidal structures, which often possess well-recognized liquid crystalline morphologies (or “mesophases”), is currently understood to impact the way nutrients are transported in the gut and absorbed. The formation of these liquid crystalline structures has also been of interest within the field of drug delivery, as it enables the encapsulation or solubilization of poorly water-soluble drugs in the aqueous environment of the gut enabling a means of absorption. This review summarizes the evidence for structure formation during the digestion of different lipid systems associated with foods, the techniques used to characterize them and provides areas of focus for advancing our understanding of this emerging field. |
format | Online Article Text |
id | pubmed-8231029 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82310292021-06-26 Formation of Self-Assembled Mesophases During Lipid Digestion Pham, Anna C. Clulow, Andrew J. Boyd, Ben J. Front Cell Dev Biol Cell and Developmental Biology Lipids play an important role in regulating bodily functions and providing a source of energy. Lipids enter the body primarily in the form of triglycerides in our diet. The gastrointestinal digestion of certain types of lipids has been shown to promote the self-assembly of lipid digestion products into highly ordered colloidal structures. The formation of these ordered colloidal structures, which often possess well-recognized liquid crystalline morphologies (or “mesophases”), is currently understood to impact the way nutrients are transported in the gut and absorbed. The formation of these liquid crystalline structures has also been of interest within the field of drug delivery, as it enables the encapsulation or solubilization of poorly water-soluble drugs in the aqueous environment of the gut enabling a means of absorption. This review summarizes the evidence for structure formation during the digestion of different lipid systems associated with foods, the techniques used to characterize them and provides areas of focus for advancing our understanding of this emerging field. Frontiers Media S.A. 2021-06-11 /pmc/articles/PMC8231029/ /pubmed/34178984 http://dx.doi.org/10.3389/fcell.2021.657886 Text en Copyright © 2021 Pham, Clulow and Boyd. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Pham, Anna C. Clulow, Andrew J. Boyd, Ben J. Formation of Self-Assembled Mesophases During Lipid Digestion |
title | Formation of Self-Assembled Mesophases During Lipid Digestion |
title_full | Formation of Self-Assembled Mesophases During Lipid Digestion |
title_fullStr | Formation of Self-Assembled Mesophases During Lipid Digestion |
title_full_unstemmed | Formation of Self-Assembled Mesophases During Lipid Digestion |
title_short | Formation of Self-Assembled Mesophases During Lipid Digestion |
title_sort | formation of self-assembled mesophases during lipid digestion |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231029/ https://www.ncbi.nlm.nih.gov/pubmed/34178984 http://dx.doi.org/10.3389/fcell.2021.657886 |
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