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Tumor-derived lactate inhibit the efficacy of lenvatinib through regulating PD-L1 expression on neutrophil in hepatocellular carcinoma

BACKGROUND: Neutrophils play a controversial role in tumor development. The function of programmed cell death-1 ligand (PD-L1(+)) neutrophils, however, may inhibit the cytotoxicity of anti-tumor immunity. In this study, we elucidate the stimulators of PD-L1(+) neutrophils in tumor microenvironment (...

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Detalles Bibliográficos
Autores principales:	Deng, Haijing, Kan, Anna, Lyu, Ning, He, Meng, Huang, Xin, Qiao, Shuang, Li, Shaolong, Lu, Wenhua, Xie, Qiankun, Chen, Huiming, Lai, Jinfa, Chen, Qifeng, Jiang, Xiongying, Liu, Shousheng, Zhang, Zhenfeng, Zhao, Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Clinical/Translational Cancer Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231064/ https://www.ncbi.nlm.nih.gov/pubmed/34168004 http://dx.doi.org/10.1136/jitc-2020-002305

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