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Mucoadhesive and Rheological Studies on the Co-Hydrogel Systems of Poly(Ethylene Glycol) Copolymers with Fluoroalkyl and Poly(Acrylic Acid)

A self-assembled co-hydrogel system with sol-gel two-phase coexistence and mucoadhesive properties was developed based on the combined properties of fluoroalkyl double-ended poly(ethylene glycol) (R(f)-PEG-R(f)) and poly(acrylic acid) (PAA), respectively. We have synthesized an R(f)-PEG-g-PAA (where...

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Autores principales: Sun, Yang, Perez, Adiel F., Cardoza, Ivy L., Baluyot-Reyes, Nina, Ba, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231137/
https://www.ncbi.nlm.nih.gov/pubmed/34204627
http://dx.doi.org/10.3390/polym13121956
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author Sun, Yang
Perez, Adiel F.
Cardoza, Ivy L.
Baluyot-Reyes, Nina
Ba, Yong
author_facet Sun, Yang
Perez, Adiel F.
Cardoza, Ivy L.
Baluyot-Reyes, Nina
Ba, Yong
author_sort Sun, Yang
collection PubMed
description A self-assembled co-hydrogel system with sol-gel two-phase coexistence and mucoadhesive properties was developed based on the combined properties of fluoroalkyl double-ended poly(ethylene glycol) (R(f)-PEG-R(f)) and poly(acrylic acid) (PAA), respectively. We have synthesized an R(f)-PEG-g-PAA (where g denotes grafted) copolymer and integrated it into the R(f)-PEG-R(f) physically cross-linked micellar network to form a co-hydrogel system. Tensile strengths between the co-hydrogel surfaces and two different sets of mucosal surfaces were acquired. One mucosal surface was made of porcine stomach mucin Type II, while the other one is a pig small intestine. The experimental results show that the largest maximum detachment stresses (MDSs) were obtained when the R(f)-PEG-g-PAA’s weight percent in the dehydrated polymer mixture is ~15%. Tensile experiments also found that MDSs are greater in acidic conditions (pH = 4–5) (123.3 g/cm(2) for the artificial mucus, and 43.0 g/cm(2) for pig small intestine) and basic conditions (pH = 10.6) (126.9 g/cm(2), and 44.6 g.cm(2), respectively) than in neutral pH (45.4 g/cm(2), and 30.7 g.cm(2), respectively). Results of the rheological analyses using shear strain amplitude sweep and frequency sweep reveal that the R(f)-PEG-g-PAA was physically integrated into the R(f)-PEG-R(f) micellar network, and the co-hydrogels remain physically cross-linked in three-dimensional micellar networks with long-term physical dispersion stability. Therefore, the co-hydrogel system is promising for drug delivery applications on mucosal surfaces.
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spelling pubmed-82311372021-06-26 Mucoadhesive and Rheological Studies on the Co-Hydrogel Systems of Poly(Ethylene Glycol) Copolymers with Fluoroalkyl and Poly(Acrylic Acid) Sun, Yang Perez, Adiel F. Cardoza, Ivy L. Baluyot-Reyes, Nina Ba, Yong Polymers (Basel) Article A self-assembled co-hydrogel system with sol-gel two-phase coexistence and mucoadhesive properties was developed based on the combined properties of fluoroalkyl double-ended poly(ethylene glycol) (R(f)-PEG-R(f)) and poly(acrylic acid) (PAA), respectively. We have synthesized an R(f)-PEG-g-PAA (where g denotes grafted) copolymer and integrated it into the R(f)-PEG-R(f) physically cross-linked micellar network to form a co-hydrogel system. Tensile strengths between the co-hydrogel surfaces and two different sets of mucosal surfaces were acquired. One mucosal surface was made of porcine stomach mucin Type II, while the other one is a pig small intestine. The experimental results show that the largest maximum detachment stresses (MDSs) were obtained when the R(f)-PEG-g-PAA’s weight percent in the dehydrated polymer mixture is ~15%. Tensile experiments also found that MDSs are greater in acidic conditions (pH = 4–5) (123.3 g/cm(2) for the artificial mucus, and 43.0 g/cm(2) for pig small intestine) and basic conditions (pH = 10.6) (126.9 g/cm(2), and 44.6 g.cm(2), respectively) than in neutral pH (45.4 g/cm(2), and 30.7 g.cm(2), respectively). Results of the rheological analyses using shear strain amplitude sweep and frequency sweep reveal that the R(f)-PEG-g-PAA was physically integrated into the R(f)-PEG-R(f) micellar network, and the co-hydrogels remain physically cross-linked in three-dimensional micellar networks with long-term physical dispersion stability. Therefore, the co-hydrogel system is promising for drug delivery applications on mucosal surfaces. MDPI 2021-06-12 /pmc/articles/PMC8231137/ /pubmed/34204627 http://dx.doi.org/10.3390/polym13121956 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sun, Yang
Perez, Adiel F.
Cardoza, Ivy L.
Baluyot-Reyes, Nina
Ba, Yong
Mucoadhesive and Rheological Studies on the Co-Hydrogel Systems of Poly(Ethylene Glycol) Copolymers with Fluoroalkyl and Poly(Acrylic Acid)
title Mucoadhesive and Rheological Studies on the Co-Hydrogel Systems of Poly(Ethylene Glycol) Copolymers with Fluoroalkyl and Poly(Acrylic Acid)
title_full Mucoadhesive and Rheological Studies on the Co-Hydrogel Systems of Poly(Ethylene Glycol) Copolymers with Fluoroalkyl and Poly(Acrylic Acid)
title_fullStr Mucoadhesive and Rheological Studies on the Co-Hydrogel Systems of Poly(Ethylene Glycol) Copolymers with Fluoroalkyl and Poly(Acrylic Acid)
title_full_unstemmed Mucoadhesive and Rheological Studies on the Co-Hydrogel Systems of Poly(Ethylene Glycol) Copolymers with Fluoroalkyl and Poly(Acrylic Acid)
title_short Mucoadhesive and Rheological Studies on the Co-Hydrogel Systems of Poly(Ethylene Glycol) Copolymers with Fluoroalkyl and Poly(Acrylic Acid)
title_sort mucoadhesive and rheological studies on the co-hydrogel systems of poly(ethylene glycol) copolymers with fluoroalkyl and poly(acrylic acid)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231137/
https://www.ncbi.nlm.nih.gov/pubmed/34204627
http://dx.doi.org/10.3390/polym13121956
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