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Advances in Molecularly Imprinted Polymers as Drug Delivery Systems
Despite the tremendous efforts made in the past decades, severe side/toxic effects and poor bioavailability still represent the main challenges that hinder the clinical translation of drug molecules. This has turned the attention of investigators towards drug delivery vehicles that provide a localiz...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231147/ https://www.ncbi.nlm.nih.gov/pubmed/34208380 http://dx.doi.org/10.3390/molecules26123589 |
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author | Liu, Rui Poma, Alessandro |
author_facet | Liu, Rui Poma, Alessandro |
author_sort | Liu, Rui |
collection | PubMed |
description | Despite the tremendous efforts made in the past decades, severe side/toxic effects and poor bioavailability still represent the main challenges that hinder the clinical translation of drug molecules. This has turned the attention of investigators towards drug delivery vehicles that provide a localized and controlled drug delivery. Molecularly imprinted polymers (MIPs) as novel and versatile drug delivery vehicles have been widely studied in recent years due to the advantages of selective recognition, enhanced drug loading, sustained release, and robustness in harsh conditions. This review highlights the design and development of strategies undertaken for MIPs used as drug delivery vehicles involving different drug delivery mechanisms, such as rate-programmed, stimuli-responsive and active targeting, published during the course of the past five years. |
format | Online Article Text |
id | pubmed-8231147 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82311472021-06-26 Advances in Molecularly Imprinted Polymers as Drug Delivery Systems Liu, Rui Poma, Alessandro Molecules Review Despite the tremendous efforts made in the past decades, severe side/toxic effects and poor bioavailability still represent the main challenges that hinder the clinical translation of drug molecules. This has turned the attention of investigators towards drug delivery vehicles that provide a localized and controlled drug delivery. Molecularly imprinted polymers (MIPs) as novel and versatile drug delivery vehicles have been widely studied in recent years due to the advantages of selective recognition, enhanced drug loading, sustained release, and robustness in harsh conditions. This review highlights the design and development of strategies undertaken for MIPs used as drug delivery vehicles involving different drug delivery mechanisms, such as rate-programmed, stimuli-responsive and active targeting, published during the course of the past five years. MDPI 2021-06-11 /pmc/articles/PMC8231147/ /pubmed/34208380 http://dx.doi.org/10.3390/molecules26123589 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Liu, Rui Poma, Alessandro Advances in Molecularly Imprinted Polymers as Drug Delivery Systems |
title | Advances in Molecularly Imprinted Polymers as Drug Delivery Systems |
title_full | Advances in Molecularly Imprinted Polymers as Drug Delivery Systems |
title_fullStr | Advances in Molecularly Imprinted Polymers as Drug Delivery Systems |
title_full_unstemmed | Advances in Molecularly Imprinted Polymers as Drug Delivery Systems |
title_short | Advances in Molecularly Imprinted Polymers as Drug Delivery Systems |
title_sort | advances in molecularly imprinted polymers as drug delivery systems |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231147/ https://www.ncbi.nlm.nih.gov/pubmed/34208380 http://dx.doi.org/10.3390/molecules26123589 |
work_keys_str_mv | AT liurui advancesinmolecularlyimprintedpolymersasdrugdeliverysystems AT pomaalessandro advancesinmolecularlyimprintedpolymersasdrugdeliverysystems |