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Cerebrolysin Combined with Rehabilitation Enhances Motor Recovery and Prevents Neural Network Degeneration in Ischemic Stroke Patients with Severe Motor Deficits

The objective of this study was to evaluate whether Cerebrolysin combined with rehabilitation therapy supports additional motor recovery in stroke patients with severe motor impairment. This study analyzed the combined data from the two phase IV prospective, multicenter, randomized, double-blind, pl...

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Autores principales: Chang, Won Hyuk, Lee, Jungsoo, Shin, Yong-Il, Ko, Myoung-Hwan, Kim, Deog Young, Sohn, Min Kyun, Kim, Jinuk, Kim, Yun-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231166/
https://www.ncbi.nlm.nih.gov/pubmed/34208352
http://dx.doi.org/10.3390/jpm11060545
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author Chang, Won Hyuk
Lee, Jungsoo
Shin, Yong-Il
Ko, Myoung-Hwan
Kim, Deog Young
Sohn, Min Kyun
Kim, Jinuk
Kim, Yun-Hee
author_facet Chang, Won Hyuk
Lee, Jungsoo
Shin, Yong-Il
Ko, Myoung-Hwan
Kim, Deog Young
Sohn, Min Kyun
Kim, Jinuk
Kim, Yun-Hee
author_sort Chang, Won Hyuk
collection PubMed
description The objective of this study was to evaluate whether Cerebrolysin combined with rehabilitation therapy supports additional motor recovery in stroke patients with severe motor impairment. This study analyzed the combined data from the two phase IV prospective, multicenter, randomized, double-blind, placebo-controlled trials. Stroke patients were included within seven days after stroke onset and were randomized to receive a 21-day treatment course of either Cerebrolysin or placebo with standardized rehabilitation therapy. Assessments were performed at baseline, immediately after the treatment course, and 90 days after stroke onset. The plasticity of the motor system was assessed by diffusion tensor imaging and resting state fMRI. In total, 110 stroke patients were included for the full analysis set (Cerebrolysin n = 59, placebo n = 51). Both groups showed significant motor recovery over time. Repeated-measures analysis of varianceshowed a significant interaction between time and type of intervention as measured by the Fugl–Meyer Assessment (p < 0.05). The Cerebrolysin group demonstrated less degenerative changes in the major motor-related white matter tracts over time than the placebo group. In conclusion, Cerebrolysin treatment as an add-on to a rehabilitation program is a promising pharmacologic approach that is worth considering in order to enhance motor recovery in ischemic stroke patients with severe motor impairment.
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spelling pubmed-82311662021-06-26 Cerebrolysin Combined with Rehabilitation Enhances Motor Recovery and Prevents Neural Network Degeneration in Ischemic Stroke Patients with Severe Motor Deficits Chang, Won Hyuk Lee, Jungsoo Shin, Yong-Il Ko, Myoung-Hwan Kim, Deog Young Sohn, Min Kyun Kim, Jinuk Kim, Yun-Hee J Pers Med Article The objective of this study was to evaluate whether Cerebrolysin combined with rehabilitation therapy supports additional motor recovery in stroke patients with severe motor impairment. This study analyzed the combined data from the two phase IV prospective, multicenter, randomized, double-blind, placebo-controlled trials. Stroke patients were included within seven days after stroke onset and were randomized to receive a 21-day treatment course of either Cerebrolysin or placebo with standardized rehabilitation therapy. Assessments were performed at baseline, immediately after the treatment course, and 90 days after stroke onset. The plasticity of the motor system was assessed by diffusion tensor imaging and resting state fMRI. In total, 110 stroke patients were included for the full analysis set (Cerebrolysin n = 59, placebo n = 51). Both groups showed significant motor recovery over time. Repeated-measures analysis of varianceshowed a significant interaction between time and type of intervention as measured by the Fugl–Meyer Assessment (p < 0.05). The Cerebrolysin group demonstrated less degenerative changes in the major motor-related white matter tracts over time than the placebo group. In conclusion, Cerebrolysin treatment as an add-on to a rehabilitation program is a promising pharmacologic approach that is worth considering in order to enhance motor recovery in ischemic stroke patients with severe motor impairment. MDPI 2021-06-11 /pmc/articles/PMC8231166/ /pubmed/34208352 http://dx.doi.org/10.3390/jpm11060545 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chang, Won Hyuk
Lee, Jungsoo
Shin, Yong-Il
Ko, Myoung-Hwan
Kim, Deog Young
Sohn, Min Kyun
Kim, Jinuk
Kim, Yun-Hee
Cerebrolysin Combined with Rehabilitation Enhances Motor Recovery and Prevents Neural Network Degeneration in Ischemic Stroke Patients with Severe Motor Deficits
title Cerebrolysin Combined with Rehabilitation Enhances Motor Recovery and Prevents Neural Network Degeneration in Ischemic Stroke Patients with Severe Motor Deficits
title_full Cerebrolysin Combined with Rehabilitation Enhances Motor Recovery and Prevents Neural Network Degeneration in Ischemic Stroke Patients with Severe Motor Deficits
title_fullStr Cerebrolysin Combined with Rehabilitation Enhances Motor Recovery and Prevents Neural Network Degeneration in Ischemic Stroke Patients with Severe Motor Deficits
title_full_unstemmed Cerebrolysin Combined with Rehabilitation Enhances Motor Recovery and Prevents Neural Network Degeneration in Ischemic Stroke Patients with Severe Motor Deficits
title_short Cerebrolysin Combined with Rehabilitation Enhances Motor Recovery and Prevents Neural Network Degeneration in Ischemic Stroke Patients with Severe Motor Deficits
title_sort cerebrolysin combined with rehabilitation enhances motor recovery and prevents neural network degeneration in ischemic stroke patients with severe motor deficits
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231166/
https://www.ncbi.nlm.nih.gov/pubmed/34208352
http://dx.doi.org/10.3390/jpm11060545
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