Cargando…

Biphenylalkoxyamine Derivatives–Histamine H(3) Receptor Ligands with Butyrylcholinesterase Inhibitory Activity

Neurodegenerative diseases, e.g., Alzheimer’s disease (AD), are a key health problem in the aging population. The lack of effective therapy and diagnostics does not help to improve this situation. It is thought that ligands influencing multiple but interconnected targets can contribute to a desired...

Descripción completa

Detalles Bibliográficos
Autores principales:	Łażewska, Dorota, Zaręba, Paula, Godyń, Justyna, Doroz-Płonka, Agata, Frank, Annika, Reiner-Link, David, Bajda, Marek, Stary, Dorota, Mogilski, Szczepan, Olejarz-Maciej, Agnieszka, Kaleta, Maria, Stark, Holger, Malawska, Barbara, Kieć-Kononowicz, Katarzyna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231170/ https://www.ncbi.nlm.nih.gov/pubmed/34208297 http://dx.doi.org/10.3390/molecules26123580

Ejemplares similares

Benzophenone Derivatives with Histamine H(3) Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer’s Disease
por: Godyń, Justyna, et al.
Publicado: (2022)

Multitargeting Histamine H(3) Receptor Ligands among Acetyl- and Propionyl-Phenoxyalkyl Derivatives
por: Łażewska, Dorota, et al.
Publicado: (2023)

Dual Target Ligands with 4-tert-Butylphenoxy Scaffold as Histamine H(3) Receptor Antagonists and Monoamine Oxidase B Inhibitors
por: Łażewska, Dorota, et al.
Publicado: (2020)

Trisubstituted 1,3,5-Triazines as Histamine H(4) Receptor Antagonists with Promising Activity In Vivo
por: Olejarz-Maciej, Agnieszka, et al.
Publicado: (2023)

Dual Targeting Ligands—Histamine H(3) Receptor Ligands with Monoamine Oxidase B Inhibitory Activity—In Vitro and In Vivo Evaluation
por: Łażewska, Dorota, et al.
Publicado: (2022)

Aryl-1,3,5-triazine ligands of histamine H(4) receptor attenuate inflammatory and nociceptive response to carrageen, zymosan and lipopolysaccharide
por: Mogilski, Szczepan, et al.
Publicado: (2016)

Efficacy of the Multi-Target Compound E153 in Relieving Pain and Pruritus of Different Origins
por: Mogilski, Szczepan, et al.
Publicado: (2023)

The Histamine H3 Receptor Antagonist E159 Reverses Memory Deficits Induced by Dizocilpine in Passive Avoidance and Novel Object Recognition Paradigm in Rats
por: Alachkar, Alaa, et al.
Publicado: (2017)

Simultaneous Blockade of Histamine H(3) Receptors and Inhibition of Acetylcholine Esterase Alleviate Autistic-Like Behaviors in BTBR T+ tf/J Mouse Model of Autism
por: Eissa, Nermin, et al.
Publicado: (2020)

Histamine H3 receptor antagonist E177 attenuates amnesia induced by dizocilpine without modulation of anxiety-like behaviors in rats
por: Alachkar, Alaa, et al.
Publicado: (2019)

LC–MS–MS Method for the Analysis of New Non-Imidazole Histamine H(3) Receptor Antagonist 1-[3-(4-tert-Butylphenoxy)propyl]piperidine in Rat Serum—Application to Pharmacokinetic Studies
por: Szafarz, Malgorzata, et al.
Publicado: (2011)

The Histamine H3 Receptor Antagonist DL77 Ameliorates MK801-Induced Memory Deficits in Rats
por: Eissa, Nermin, et al.
Publicado: (2018)

Dual Piperidine-Based Histamine H(3) and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain
por: Szczepańska, Katarzyna, et al.
Publicado: (2023)

The Neuroprotective Effects of Histamine H3 Receptor Antagonist E177 on Pilocarpine-Induced Status Epilepticus in Rats
por: Alachkar, Alaa, et al.
Publicado: (2019)

Role of Histamine H(3) Receptor Antagonists on Intraocular Pressure Reduction in Rabbit Models of Transient Ocular Hypertension and Glaucoma
por: Lanzi, Cecilia, et al.
Publicado: (2019)

Chalcones as Potential Ligands for the Treatment of Parkinson’s Disease
por: Królicka, Ewelina, et al.
Publicado: (2022)

The Dual-Active Histamine H(3) Receptor Antagonist and Acetylcholine Esterase Inhibitor E100 Alleviates Autistic-Like Behaviors and Oxidative Stress in Valproic Acid Induced Autism in Mice
por: Eissa, Nermin, et al.
Publicado: (2020)

Studies on Anticonvulsant Effects of Novel Histamine H3R Antagonists in Electrically and Chemically Induced Seizures in Rats
por: Alachkar, Alaa, et al.
Publicado: (2018)

Are the Hydantoin-1,3,5-triazine 5-HT(6)R Ligands a Hope to a Find New Procognitive and Anti-Obesity Drug? Considerations Based on Primary In Vivo Assays and ADME-Tox Profile In Vitro
por: Lubelska, Annamaria, et al.
Publicado: (2019)

Discovery of Potential, Dual-Active Histamine H(3) Receptor Ligands with Combined Antioxidant Properties
por: Kuder, Kamil J., et al.
Publicado: (2021)

Guanidines: Synthesis of Novel Histamine H(3)R Antagonists with Additional Breast Anticancer Activity and Cholinesterases Inhibitory Effect
por: Staszewski, Marek, et al.
Publicado: (2023)

Anti-inflammatory effects of new human histamine H(3) receptor ligands with flavonoid structure on BV-2 neuroinflammation
por: Honkisz-Orzechowska, Ewelina, et al.
Publicado: (2022)

The Potent and Selective Histamine H3 Receptor Antagonist E169 Counteracts Cognitive Deficits and Mitigates Disturbances in the PI3K/AKT/GSK-3β Signaling Pathway in MK801-Induced Amnesia in Mice
por: Abdalla, Sabna, et al.
Publicado: (2023)

Antagonism of Histamine H3 receptors Alleviates Pentylenetetrazole-Induced Kindling and Associated Memory Deficits by Mitigating Oxidative Stress, Central Neurotransmitters, and c-Fos Protein Expression in Rats
por: Alachkar, Alaa, et al.
Publicado: (2020)

Non-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats
por: Sadek, Bassem, et al.
Publicado: (2016)

The histamine H3R antagonist DL77 attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism
por: Eissa, Nermin, et al.
Publicado: (2018)

Molecular Modeling Studies on the Multistep Reactivation Process of Organophosphate-Inhibited Acetylcholinesterase and Butyrylcholinesterase
por: Jończyk, Jakub, et al.
Publicado: (2021)

Hybrid approach to structure modeling of the histamine H3 receptor: Multi-level assessment as a tool for model verification
por: Jończyk, Jakub, et al.
Publicado: (2017)

Taurine and Creatine Transporters as Potential Drug Targets in Cancer Therapy
por: Stary, Dorota, et al.
Publicado: (2023)

Anti-Inflammatory Activities of 8-Benzylaminoxanthines Showing High Adenosine A(2A) and Dual A(1)/A(2A) Receptor Affinity
por: Załuski, Michał, et al.
Publicado: (2023)

Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H(3) and Sigma-1 Receptor Antagonists with Promising Antinociceptive Properties
por: Szczepańska, Katarzyna, et al.
Publicado: (2021)

Cunninghamella as a Microbiological Model for Metabolism of Histamine H(3) Receptor Antagonist 1-[3-(4-tert-Butylphenoxy)propyl]piperidine
por: Pękala, Elżbieta, et al.
Publicado: (2012)

Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer’s disease
por: Szałaj, Natalia, et al.
Publicado: (2020)

Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents
por: Panek, Dawid, et al.
Publicado: (2018)

The histamine H(3) receptor inverse agonist pitolisant reduces body weight in obese mice
por: Kotańska, Magdalena, et al.
Publicado: (2018)

Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta
por: Hebda, Michalina, et al.
Publicado: (2016)

Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates
por: Lee, Hyun Myung, et al.
Publicado: (2021)

Anticonvulsant and reproductive toxicological studies of the imidazole-based histamine H3R antagonist 2-18 in mice
por: Bastaki, Salim M, et al.
Publicado: (2018)

Evaluation of Some Safety Parameters of Dual Histamine H(3) and Sigma-2 Receptor Ligands with Anti-Obesity Potential
por: Mika, Kamil, et al.
Publicado: (2023)

Antiplatelet Effects of Selected Xanthine-Based Adenosine A(2A) and A(2B) Receptor Antagonists Determined in Rat Blood
por: Kubacka, Monika, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_oertslsr96nvd7e4u3ur2kphra