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The Female Reproductive Tract Microbiome—Implications for Gynecologic Cancers and Personalized Medicine

The microbial colonization of the lower female reproductive tract has been extensively studied over the past few decades. In contrast, the upper female reproductive tract including the uterine cavity and peritoneum where the ovaries and fallopian tubes reside were traditionally assumed to be sterile...

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Detalles Bibliográficos
Autores principales: Rizzo, Anthony E., Gordon, Jennifer C., Berard, Alicia R., Burgener, Adam D., Avril, Stefanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231212/
https://www.ncbi.nlm.nih.gov/pubmed/34208337
http://dx.doi.org/10.3390/jpm11060546
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author Rizzo, Anthony E.
Gordon, Jennifer C.
Berard, Alicia R.
Burgener, Adam D.
Avril, Stefanie
author_facet Rizzo, Anthony E.
Gordon, Jennifer C.
Berard, Alicia R.
Burgener, Adam D.
Avril, Stefanie
author_sort Rizzo, Anthony E.
collection PubMed
description The microbial colonization of the lower female reproductive tract has been extensively studied over the past few decades. In contrast, the upper female reproductive tract including the uterine cavity and peritoneum where the ovaries and fallopian tubes reside were traditionally assumed to be sterile under non-pathologic conditions. However, recent studies applying next-generation sequencing of the bacterial 16S ribosomal RNA gene have provided convincing evidence for the existence of an upper female reproductive tract microbiome. While the vaginal microbiome and its importance for reproductive health outcomes has been extensively studied, the microbiome of the upper female reproductive tract and its relevance for gynecologic cancers has been less studied and will be the focus of this article. This targeted review summarizes the pertinent literature on the female reproductive tract microbiome in gynecologic malignancies and its anticipated role in future research and clinical applications in personalized medicine.
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spelling pubmed-82312122021-06-26 The Female Reproductive Tract Microbiome—Implications for Gynecologic Cancers and Personalized Medicine Rizzo, Anthony E. Gordon, Jennifer C. Berard, Alicia R. Burgener, Adam D. Avril, Stefanie J Pers Med Review The microbial colonization of the lower female reproductive tract has been extensively studied over the past few decades. In contrast, the upper female reproductive tract including the uterine cavity and peritoneum where the ovaries and fallopian tubes reside were traditionally assumed to be sterile under non-pathologic conditions. However, recent studies applying next-generation sequencing of the bacterial 16S ribosomal RNA gene have provided convincing evidence for the existence of an upper female reproductive tract microbiome. While the vaginal microbiome and its importance for reproductive health outcomes has been extensively studied, the microbiome of the upper female reproductive tract and its relevance for gynecologic cancers has been less studied and will be the focus of this article. This targeted review summarizes the pertinent literature on the female reproductive tract microbiome in gynecologic malignancies and its anticipated role in future research and clinical applications in personalized medicine. MDPI 2021-06-11 /pmc/articles/PMC8231212/ /pubmed/34208337 http://dx.doi.org/10.3390/jpm11060546 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rizzo, Anthony E.
Gordon, Jennifer C.
Berard, Alicia R.
Burgener, Adam D.
Avril, Stefanie
The Female Reproductive Tract Microbiome—Implications for Gynecologic Cancers and Personalized Medicine
title The Female Reproductive Tract Microbiome—Implications for Gynecologic Cancers and Personalized Medicine
title_full The Female Reproductive Tract Microbiome—Implications for Gynecologic Cancers and Personalized Medicine
title_fullStr The Female Reproductive Tract Microbiome—Implications for Gynecologic Cancers and Personalized Medicine
title_full_unstemmed The Female Reproductive Tract Microbiome—Implications for Gynecologic Cancers and Personalized Medicine
title_short The Female Reproductive Tract Microbiome—Implications for Gynecologic Cancers and Personalized Medicine
title_sort female reproductive tract microbiome—implications for gynecologic cancers and personalized medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231212/
https://www.ncbi.nlm.nih.gov/pubmed/34208337
http://dx.doi.org/10.3390/jpm11060546
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