Cargando…

Novel mutual prodrug of 5-fluorouracil and heme oxygenase-1 inhibitor (5-FU/HO-1 hybrid): design and preliminary in vitro evaluation

In this work, the first mutual prodrug of 5-fluorouracil and heme oxygenase1 inhibitor (5-FU/HO-1 hybrid) has been designed, synthesised, and evaluated for its in vitro chemical and enzymatic hydrolysis stability. Predicted in silico physicochemical properties of the newly synthesised hybrid (3) dem...

Descripción completa

Detalles Bibliográficos
Autores principales:	Salerno, Loredana, Vanella, Luca, Sorrenti, Valeria, Consoli, Valeria, Ciaffaglione, Valeria, Fallica, Antonino N., Canale, Vittorio, Zajdel, Paweł, Pignatello, Rosario, Intagliata, Sebastiano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231349/ https://www.ncbi.nlm.nih.gov/pubmed/34167427 http://dx.doi.org/10.1080/14756366.2021.1928111

Ejemplares similares

Mutual Prodrugs of 5‐Fluorouracil: From a Classic Chemotherapeutic Agent to Novel Potential Anticancer Drugs
por: Ciaffaglione, Valeria, et al.
Publicado: (2021)

Heme Oxygenase Modulation Drives Ferroptosis in TNBC Cells
por: Consoli, Valeria, et al.
Publicado: (2022)

Heme Oxygenase-1 Signaling and Redox Homeostasis in Physiopathological Conditions
por: Consoli, Valeria, et al.
Publicado: (2021)

Discovery of Novel Acetamide-Based Heme Oxygenase-1 Inhibitors with Potent In Vitro Antiproliferative Activity
por: Fallica, Antonino N., et al.
Publicado: (2021)

Combination of Heme Oxygenase-1 Inhibition and Sigma Receptor Modulation for Anticancer Activity
por: Romeo, Giuseppe, et al.
Publicado: (2021)

Novel Heme Oxygenase-1 (HO-1) Inducers Based on Dimethyl Fumarate Structure
por: Sorrenti, Valeria, et al.
Publicado: (2020)

New Arylethanolimidazole Derivatives as HO-1 Inhibitors with Cytotoxicity against MCF-7 Breast Cancer Cells
por: Ciaffaglione, Valeria, et al.
Publicado: (2020)

Tin Mesoporphyrin Selectively Reduces Non-Small-Cell Lung Cancer Cell Line A549 Proliferation by Interfering with Heme Oxygenase and Glutathione Systems
por: Sorrenti, Valeria, et al.
Publicado: (2021)

Protective Effects of Caffeic Acid Phenethyl Ester (CAPE) and Novel Cape Analogue as Inducers of Heme Oxygenase-1 in Streptozotocin-Induced Type 1 Diabetic Rats
por: Sorrenti, Valeria, et al.
Publicado: (2019)

Novel Tyrosine Kinase Inhibitors to Target Chronic Myeloid Leukemia
por: Ciaffaglione, Valeria, et al.
Publicado: (2022)

Novel Structural Insight into Inhibitors of Heme Oxygenase-1 (HO-1) by New Imidazole-Based Compounds: Biochemical and In Vitro Anticancer Activity Evaluation
por: Greish, Khaled F., et al.
Publicado: (2018)

Editorial of Special Issue “Protective and Detrimental Role of Heme Oxygenase-1”
por: Sorrenti, Valeria
Publicado: (2019)

Editorial of Special Issue “Protective and Detrimental Role of Heme Oxygenase-1”: 2021
por: Sorrenti, Valeria
Publicado: (2023)

Inhibition of Heme Oxygenase Antioxidant Activity Exacerbates Hepatic Steatosis and Fibrosis In Vitro
por: Raffaele, Marco, et al.
Publicado: (2019)

Heme Oxygenase-1 Inhibition Sensitizes Human Prostate Cancer Cells towards Glucose Deprivation and Metformin-Mediated Cell Death
por: Raffaele, Marco, et al.
Publicado: (2019)

Recent Advances in Health Benefits of Bioactive Compounds from Food Wastes and By-Products: Biochemical Aspects
por: Sorrenti, Valeria, et al.
Publicado: (2023)

Novel Heme Oxygenase-1 Inducers Palliate Inflammatory Pain and Emotional Disorders by Regulating NLRP3 Inflammasome and Activating the Antioxidant Pathway
por: Pérez-Fernández, Montse, et al.
Publicado: (2023)

From Far West to East: Joining the Molecular Architecture of Imidazole-like Ligands in HO-1 Complexes
por: Floresta, Giuseppe, et al.
Publicado: (2021)

Fluorouracil (5-FU)-induced Cardiomyopathy
por: Thalambedu, Nishanth, et al.
Publicado: (2019)

Beneficial Effects of Standardized Extracts from Wastes of Red Oranges and Olive Leaves
por: Burò, Ilaria, et al.
Publicado: (2022)

The non-canonical functions of the heme oxygenases
por: Vanella, Luca, et al.
Publicado: (2016)

The Inhibition of Neuropathic Pain Incited by Nerve Injury and Accompanying Mood Disorders by New Heme Oxygenase-1 Inducers: Mechanisms Implicated
por: Suárez-Rojas, Irene, et al.
Publicado: (2023)

Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery
por: De Angelis, Paula M, et al.
Publicado: (2006)

Regulation of Complement Activation by Heme Oxygenase-1 (HO-1) in Kidney Injury
por: Detsika, Maria G., et al.
Publicado: (2021)

Effect of Skimmed Milk on the Absorption and Metabolism of5-Fluorouracil (5-FU) in Animals
por: Ahmad, Maqsood, et al.
Publicado: (2012)

A unique presentation of 5-fluorouracil (5-FU) induced cerebral encephalopathy
por: Naik, Shailendra S, et al.
Publicado: (2020)

Heme oxygenase-2 (HO-2) binds and buffers labile ferric heme in human embryonic kidney cells
por: Hanna, David A., et al.
Publicado: (2021)

Anti-Inflammatory Effect of Angelica gigas via Heme Oxygenase (HO)-1 Expression
por: Cho, Joon Hyeong, et al.
Publicado: (2015)

Therapeutic Efficacy of Stem Cells Transplantation in Diabetes: Role of Heme Oxygenase
por: Raffaele, Marco, et al.
Publicado: (2016)

Pharmacokinetics and pharmacodynamics of locoregional 5 fluorouracil (5FU) in advanced colorectal liver metastases.
por: Goldberg, J. A., et al.
Publicado: (1988)

Optimization of Lipid Nanoparticles by Response Surface Methodology to Improve the Ocular Delivery of Diosmin: Characterization and In-Vitro Anti-Inflammatory Assessment
por: Zingale, Elide, et al.
Publicado: (2022)

Carbon Monoxide (CO) as a Retinal Regulator of Heme Oxygenases -1, and -2 (HO’s) Expression
por: Nowak, Sławomir, et al.
Publicado: (2022)

Modulation of Metastasis and Stemness-Associated Genes by Heme Oxygenase 1 (HO-1) in Prostate Cancer
por: Sabater, Agustina, et al.
Publicado: (2022)

Bioactive Compounds from Lemon (Citrus limon) Extract Overcome TNF-α-Induced Insulin Resistance in Cultured Adipocytes
por: Sorrenti, Valeria, et al.
Publicado: (2021)

Over-activation of AKT signaling leading to 5-Fluorouracil resistance in SNU-C5/5-FU cells
por: Kim, Eun-Ji, et al.
Publicado: (2018)

Standardized Extract from Wastes of Edible Flowers and Snail Mucus Ameliorate Ultraviolet B-Induced Damage in Keratinocytes
por: Vanella, Luca, et al.
Publicado: (2023)

Evaluation of the Antioxidant and Antiangiogenic Activity of a Pomegranate Extract in BPH-1 Prostate Epithelial Cells
por: Consoli, Valeria, et al.
Publicado: (2023)

Podocyte-targeted Heme Oxygenase (HO)-1 overexpression exacerbates age-related pathology in the rat kidney
por: Poulaki, Elpida, et al.
Publicado: (2020)

Deciphering the Role of Heme Oxygenase-1 (HO-1) Expressing Macrophages in Renal Ischemia-Reperfusion Injury
por: Rossi, Maxime, et al.
Publicado: (2021)

Chorioamnionitis Precipitates Perinatal Alterations of Heme-Oxygenase-1 (HO-1) Homeostasis in the Developing Rat Brain
por: Ozen, Maide, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_a2p8fmj66hoa46j5iqgrom4un9