IL-7 Immunotherapy in a Nonimmunocompromised Patient With Intractable Fungal Wound Sepsis

A nonimmunocompromised patient developed life-threatening soft tissue infection with Trichosporon asahii, Fusarium, and Saksenaea that progressed despite maximum antifungal therapies and aggressive debridement. Interleukin-7 immunotherapy resulted in clinical improvement, fungal clearance, reversal...

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Autores principales: Turnbull, Isaiah R, Mazer, Monty B, Hoofnagle, Mark H, Kirby, John P, Leonard, Jennifer M, Mejia-Chew, Carlos, Spec, Andrej, Blood, Jane, Miles, Sydney M, Ransom, Eric M, Potter, Robert F, Gaut, Joseph P, Remy, Kenneth E, Hotchkiss, Richard S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231366/
https://www.ncbi.nlm.nih.gov/pubmed/34189174
http://dx.doi.org/10.1093/ofid/ofab256
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author Turnbull, Isaiah R
Mazer, Monty B
Hoofnagle, Mark H
Kirby, John P
Leonard, Jennifer M
Mejia-Chew, Carlos
Spec, Andrej
Blood, Jane
Miles, Sydney M
Ransom, Eric M
Potter, Robert F
Gaut, Joseph P
Remy, Kenneth E
Hotchkiss, Richard S
author_facet Turnbull, Isaiah R
Mazer, Monty B
Hoofnagle, Mark H
Kirby, John P
Leonard, Jennifer M
Mejia-Chew, Carlos
Spec, Andrej
Blood, Jane
Miles, Sydney M
Ransom, Eric M
Potter, Robert F
Gaut, Joseph P
Remy, Kenneth E
Hotchkiss, Richard S
author_sort Turnbull, Isaiah R
collection PubMed
description A nonimmunocompromised patient developed life-threatening soft tissue infection with Trichosporon asahii, Fusarium, and Saksenaea that progressed despite maximum antifungal therapies and aggressive debridement. Interleukin-7 immunotherapy resulted in clinical improvement, fungal clearance, reversal of lymphopenia, and improved T-cell function. Immunoadjuvant therapies to boost host immunity may be efficacious in life-threatening fungal infections.
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spelling pubmed-82313662021-06-28 IL-7 Immunotherapy in a Nonimmunocompromised Patient With Intractable Fungal Wound Sepsis Turnbull, Isaiah R Mazer, Monty B Hoofnagle, Mark H Kirby, John P Leonard, Jennifer M Mejia-Chew, Carlos Spec, Andrej Blood, Jane Miles, Sydney M Ransom, Eric M Potter, Robert F Gaut, Joseph P Remy, Kenneth E Hotchkiss, Richard S Open Forum Infect Dis Brief Reports A nonimmunocompromised patient developed life-threatening soft tissue infection with Trichosporon asahii, Fusarium, and Saksenaea that progressed despite maximum antifungal therapies and aggressive debridement. Interleukin-7 immunotherapy resulted in clinical improvement, fungal clearance, reversal of lymphopenia, and improved T-cell function. Immunoadjuvant therapies to boost host immunity may be efficacious in life-threatening fungal infections. Oxford University Press 2021-05-23 /pmc/articles/PMC8231366/ /pubmed/34189174 http://dx.doi.org/10.1093/ofid/ofab256 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Turnbull, Isaiah R
Mazer, Monty B
Hoofnagle, Mark H
Kirby, John P
Leonard, Jennifer M
Mejia-Chew, Carlos
Spec, Andrej
Blood, Jane
Miles, Sydney M
Ransom, Eric M
Potter, Robert F
Gaut, Joseph P
Remy, Kenneth E
Hotchkiss, Richard S
IL-7 Immunotherapy in a Nonimmunocompromised Patient With Intractable Fungal Wound Sepsis
title IL-7 Immunotherapy in a Nonimmunocompromised Patient With Intractable Fungal Wound Sepsis
title_full IL-7 Immunotherapy in a Nonimmunocompromised Patient With Intractable Fungal Wound Sepsis
title_fullStr IL-7 Immunotherapy in a Nonimmunocompromised Patient With Intractable Fungal Wound Sepsis
title_full_unstemmed IL-7 Immunotherapy in a Nonimmunocompromised Patient With Intractable Fungal Wound Sepsis
title_short IL-7 Immunotherapy in a Nonimmunocompromised Patient With Intractable Fungal Wound Sepsis
title_sort il-7 immunotherapy in a nonimmunocompromised patient with intractable fungal wound sepsis
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231366/
https://www.ncbi.nlm.nih.gov/pubmed/34189174
http://dx.doi.org/10.1093/ofid/ofab256
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