Time to SARS-CoV-2 PCR Clearance in Immunocompromising Conditions: Is Test-Based Removal From Isolation Necessary in Severely Immunocompromised Individuals?

To determine the association between immunosuppression and time to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) clearance, we studied 3758 adults retested following initial SARS-CoV-2 infection. Cox proportional hazards models demonstrated delayed PCR...

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Autores principales: Epstein, Rachel L, Sperring, Heather, Hofman, Melissa, Lodi, Sara, White, Laura F, Barocas, Joshua A, Bouton, Tara C, Xiao, Yian, Hsu, Heather E, Miller, Nancy S, Linas, Benjamin P, Marathe, Jai G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231388/
https://www.ncbi.nlm.nih.gov/pubmed/34189164
http://dx.doi.org/10.1093/ofid/ofab164
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author Epstein, Rachel L
Sperring, Heather
Hofman, Melissa
Lodi, Sara
White, Laura F
Barocas, Joshua A
Bouton, Tara C
Xiao, Yian
Hsu, Heather E
Miller, Nancy S
Linas, Benjamin P
Marathe, Jai G
author_facet Epstein, Rachel L
Sperring, Heather
Hofman, Melissa
Lodi, Sara
White, Laura F
Barocas, Joshua A
Bouton, Tara C
Xiao, Yian
Hsu, Heather E
Miller, Nancy S
Linas, Benjamin P
Marathe, Jai G
author_sort Epstein, Rachel L
collection PubMed
description To determine the association between immunosuppression and time to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) clearance, we studied 3758 adults retested following initial SARS-CoV-2 infection. Cox proportional hazards models demonstrated delayed PCR clearance with older age, multiple comorbidities, and solid organ transplant but not by degree of immunocompromise. These findings challenge current retesting practices.
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spelling pubmed-82313882021-06-28 Time to SARS-CoV-2 PCR Clearance in Immunocompromising Conditions: Is Test-Based Removal From Isolation Necessary in Severely Immunocompromised Individuals? Epstein, Rachel L Sperring, Heather Hofman, Melissa Lodi, Sara White, Laura F Barocas, Joshua A Bouton, Tara C Xiao, Yian Hsu, Heather E Miller, Nancy S Linas, Benjamin P Marathe, Jai G Open Forum Infect Dis Brief Reports To determine the association between immunosuppression and time to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) clearance, we studied 3758 adults retested following initial SARS-CoV-2 infection. Cox proportional hazards models demonstrated delayed PCR clearance with older age, multiple comorbidities, and solid organ transplant but not by degree of immunocompromise. These findings challenge current retesting practices. Oxford University Press 2021-05-20 /pmc/articles/PMC8231388/ /pubmed/34189164 http://dx.doi.org/10.1093/ofid/ofab164 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Epstein, Rachel L
Sperring, Heather
Hofman, Melissa
Lodi, Sara
White, Laura F
Barocas, Joshua A
Bouton, Tara C
Xiao, Yian
Hsu, Heather E
Miller, Nancy S
Linas, Benjamin P
Marathe, Jai G
Time to SARS-CoV-2 PCR Clearance in Immunocompromising Conditions: Is Test-Based Removal From Isolation Necessary in Severely Immunocompromised Individuals?
title Time to SARS-CoV-2 PCR Clearance in Immunocompromising Conditions: Is Test-Based Removal From Isolation Necessary in Severely Immunocompromised Individuals?
title_full Time to SARS-CoV-2 PCR Clearance in Immunocompromising Conditions: Is Test-Based Removal From Isolation Necessary in Severely Immunocompromised Individuals?
title_fullStr Time to SARS-CoV-2 PCR Clearance in Immunocompromising Conditions: Is Test-Based Removal From Isolation Necessary in Severely Immunocompromised Individuals?
title_full_unstemmed Time to SARS-CoV-2 PCR Clearance in Immunocompromising Conditions: Is Test-Based Removal From Isolation Necessary in Severely Immunocompromised Individuals?
title_short Time to SARS-CoV-2 PCR Clearance in Immunocompromising Conditions: Is Test-Based Removal From Isolation Necessary in Severely Immunocompromised Individuals?
title_sort time to sars-cov-2 pcr clearance in immunocompromising conditions: is test-based removal from isolation necessary in severely immunocompromised individuals?
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231388/
https://www.ncbi.nlm.nih.gov/pubmed/34189164
http://dx.doi.org/10.1093/ofid/ofab164
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