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Ring size changes in the development of class I HDAC inhibitors

Five pathways involving different ring structures led to generation of fourteen thienylbenzamides (7–20) which display the structure-activity relationships of class I HDAC inhibitors. All the synthesised compounds inhibit HDAC1 and HDAC2 selectively over other isoforms and many inhibit DLD1 and HCT1...

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Detalles Bibliográficos
Autores principales:	Cho, Er-Chieh, Liu, Chi-Yuan, Tang, Di-Wei, Lee, Hsueh-Yun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231390/ https://www.ncbi.nlm.nih.gov/pubmed/34167419 http://dx.doi.org/10.1080/14756366.2021.1941920

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