Heparan Sulfate Facilitates Spike Protein-Mediated SARS-CoV-2 Host Cell Invasion and Contributes to Increased Infection of SARS-CoV-2 G614 Mutant and in Lung Cancer

The severe acute respiratory syndrome (SARS)-like coronavirus disease (COVID-19) is caused by SARS-CoV-2 and has been a serious threat to global public health with limited treatment. Cellular heparan sulfate (HS) has been found to bind SARS-CoV-2 spike protein (SV2-S) and co-operate with cell surfac...

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Detalles Bibliográficos
Autores principales: Yue, Jingwen, Jin, Weihua, Yang, Hua, Faulkner, John, Song, Xuehong, Qiu, Hong, Teng, Michael, Azadi, Parastoo, Zhang, Fuming, Linhardt, Robert J., Wang, Lianchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231436/
https://www.ncbi.nlm.nih.gov/pubmed/34179075
http://dx.doi.org/10.3389/fmolb.2021.649575

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