Hyperactivated RAGE in Comorbidities as a Risk Factor for Severe COVID-19—The Role of RAGE-RAS Crosstalk

The receptor for advanced glycation-end products (RAGE) is a multiligand receptor with a role in inflammatory and pulmonary pathologies. Hyperactivation of RAGE by its ligands has been reported to sustain inflammation and oxidative stress in common comorbidities of severe COVID-19. RAGE is essential...

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Autores principales: Chiappalupi, Sara, Salvadori, Laura, Donato, Rosario, Riuzzi, Francesca, Sorci, Guglielmo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231494/
https://www.ncbi.nlm.nih.gov/pubmed/34204735
http://dx.doi.org/10.3390/biom11060876
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author Chiappalupi, Sara
Salvadori, Laura
Donato, Rosario
Riuzzi, Francesca
Sorci, Guglielmo
author_facet Chiappalupi, Sara
Salvadori, Laura
Donato, Rosario
Riuzzi, Francesca
Sorci, Guglielmo
author_sort Chiappalupi, Sara
collection PubMed
description The receptor for advanced glycation-end products (RAGE) is a multiligand receptor with a role in inflammatory and pulmonary pathologies. Hyperactivation of RAGE by its ligands has been reported to sustain inflammation and oxidative stress in common comorbidities of severe COVID-19. RAGE is essential to the deleterious effects of the renin–angiotensin system (RAS), which participates in infection and multiorgan injury in COVID-19 patients. Thus, RAGE might be a major player in severe COVID-19, and appears to be a useful therapeutic molecular target in infections by SARS-CoV-2. The role of RAGE gene polymorphisms in predisposing patients to severe COVID-19 is discussed.
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spelling pubmed-82314942021-06-26 Hyperactivated RAGE in Comorbidities as a Risk Factor for Severe COVID-19—The Role of RAGE-RAS Crosstalk Chiappalupi, Sara Salvadori, Laura Donato, Rosario Riuzzi, Francesca Sorci, Guglielmo Biomolecules Review The receptor for advanced glycation-end products (RAGE) is a multiligand receptor with a role in inflammatory and pulmonary pathologies. Hyperactivation of RAGE by its ligands has been reported to sustain inflammation and oxidative stress in common comorbidities of severe COVID-19. RAGE is essential to the deleterious effects of the renin–angiotensin system (RAS), which participates in infection and multiorgan injury in COVID-19 patients. Thus, RAGE might be a major player in severe COVID-19, and appears to be a useful therapeutic molecular target in infections by SARS-CoV-2. The role of RAGE gene polymorphisms in predisposing patients to severe COVID-19 is discussed. MDPI 2021-06-12 /pmc/articles/PMC8231494/ /pubmed/34204735 http://dx.doi.org/10.3390/biom11060876 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chiappalupi, Sara
Salvadori, Laura
Donato, Rosario
Riuzzi, Francesca
Sorci, Guglielmo
Hyperactivated RAGE in Comorbidities as a Risk Factor for Severe COVID-19—The Role of RAGE-RAS Crosstalk
title Hyperactivated RAGE in Comorbidities as a Risk Factor for Severe COVID-19—The Role of RAGE-RAS Crosstalk
title_full Hyperactivated RAGE in Comorbidities as a Risk Factor for Severe COVID-19—The Role of RAGE-RAS Crosstalk
title_fullStr Hyperactivated RAGE in Comorbidities as a Risk Factor for Severe COVID-19—The Role of RAGE-RAS Crosstalk
title_full_unstemmed Hyperactivated RAGE in Comorbidities as a Risk Factor for Severe COVID-19—The Role of RAGE-RAS Crosstalk
title_short Hyperactivated RAGE in Comorbidities as a Risk Factor for Severe COVID-19—The Role of RAGE-RAS Crosstalk
title_sort hyperactivated rage in comorbidities as a risk factor for severe covid-19—the role of rage-ras crosstalk
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231494/
https://www.ncbi.nlm.nih.gov/pubmed/34204735
http://dx.doi.org/10.3390/biom11060876
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