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Exploitation of Design-of-Experiment Approach for Design and Optimization of Fast-Disintegrating Tablets for Sublingual Delivery of Sildenafil Citrate with Enhanced Bioavailability Using Fluid-Bed Granulation Technique
Sildenafil citrate undergoes first-pass metabolism, resulting in poor oral bioavailability at 25–41% of the administered dose. This study aimed to design and optimize fast-disintegrating tablets for the sublingual delivery of sildenafil citrate to improve bioavailability and facilitate rapid onset o...
Autores principales: | AlAli, Amer S., Aldawsari, Mohammed F., Alalaiwe, Ahmed, Almutairy, Bjad K., Al-Shdefat, Ramadan, Walbi, Ismail A., Fayed, Mohamed H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231530/ https://www.ncbi.nlm.nih.gov/pubmed/34204781 http://dx.doi.org/10.3390/pharmaceutics13060870 |
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