Constitutive PSGL-1 Correlates with CD30 and TCR Pathways and Represents a Potential Target for Immunotherapy in Anaplastic Large T-Cell Lymphoma

SIMPLE SUMMARY: P-selectin glycoprotein ligand-1 (PSGL-1), coded by the SELPLG gene, is the major ligand of selectins and plays a pivotal role in tethering, rolling and extravasation of immune cells. PSGL-1 involvement in core molecular programs, such as SYK, PLCγ2, PI3Kγ or MAPK pathways, suggests...

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Detalles Bibliográficos
Autores principales: Belmonte, Beatrice, Cancila, Valeria, Gulino, Alessandro, Navari, Mohsen, Arancio, Walter, Macor, Paolo, Balduit, Andrea, Capolla, Sara, Morello, Gaia, Vacca, Davide, Ferrara, Ines, Bertolazzi, Giorgio, Balistreri, Carmela Rita, Amico, Paolo, Ferrante, Federica, Maiorana, Antonino, Salviato, Tiziana, Piccaluga, Pier Paolo, Mangogna, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231564/
https://www.ncbi.nlm.nih.gov/pubmed/34204843
http://dx.doi.org/10.3390/cancers13122958

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