Peptide Triazole Thiol Irreversibly Inactivates Metastable HIV-1 Env by Accessing Conformational Triggers Intrinsic to Virus–Cell Entry

KR13, a peptide triazole thiol previously established to inhibit HIV-1 infection and cause virus lysis, was evaluated by flow cytometry against JRFL Env-presenting cells to characterize induced Env and membrane transformations leading to irreversible inactivation. Transiently transfected HEK293T cel...

Descripción completa

Detalles Bibliográficos
Autores principales: Ang, Charles Gotuaco, Carter, Erik, Haftl, Ann, Zhang, Shiyu, Rashad, Adel A., Kutzler, Michele, Abrams, Cameron F., Chaiken, Irwin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231586/
https://www.ncbi.nlm.nih.gov/pubmed/34204725
http://dx.doi.org/10.3390/microorganisms9061286

Ejemplares similares

Ejemplares similares