COVID-19 Virus Infection in Three Patients With Hypogammaglobulinemia

The world is experiencing the COVID-19 outbreak and there are no evidence-based treatment strategies available for immunocompromised patients. COVID-19 is a novel beta coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with cancer are more susceptible to infe...

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Autores principales: Gesiotto, Quinto, Cheema, Asima, Avaiya, Kishan, Shah, Bijal, Greene, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231731/
https://www.ncbi.nlm.nih.gov/pubmed/34188994
http://dx.doi.org/10.7759/cureus.15256
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author Gesiotto, Quinto
Cheema, Asima
Avaiya, Kishan
Shah, Bijal
Greene, John
author_facet Gesiotto, Quinto
Cheema, Asima
Avaiya, Kishan
Shah, Bijal
Greene, John
author_sort Gesiotto, Quinto
collection PubMed
description The world is experiencing the COVID-19 outbreak and there are no evidence-based treatment strategies available for immunocompromised patients. COVID-19 is a novel beta coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with cancer are more susceptible to infection than individuals without cancer due to their impaired humoral and cellular immune function caused by the malignancy itself and chemotherapy. We present three cases of cancer patients with hypogammaglobulinemia with varying clinical outcomes associated with infection. These include one mantle cell lymphoma patient with recurrent respiratory infection requiring intravenous immunoglobulin (IVIG) support and two multiple myeloma patients with continued viral shedding.
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spelling pubmed-82317312021-06-28 COVID-19 Virus Infection in Three Patients With Hypogammaglobulinemia Gesiotto, Quinto Cheema, Asima Avaiya, Kishan Shah, Bijal Greene, John Cureus Infectious Disease The world is experiencing the COVID-19 outbreak and there are no evidence-based treatment strategies available for immunocompromised patients. COVID-19 is a novel beta coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with cancer are more susceptible to infection than individuals without cancer due to their impaired humoral and cellular immune function caused by the malignancy itself and chemotherapy. We present three cases of cancer patients with hypogammaglobulinemia with varying clinical outcomes associated with infection. These include one mantle cell lymphoma patient with recurrent respiratory infection requiring intravenous immunoglobulin (IVIG) support and two multiple myeloma patients with continued viral shedding. Cureus 2021-05-26 /pmc/articles/PMC8231731/ /pubmed/34188994 http://dx.doi.org/10.7759/cureus.15256 Text en Copyright © 2021, Gesiotto et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Infectious Disease
Gesiotto, Quinto
Cheema, Asima
Avaiya, Kishan
Shah, Bijal
Greene, John
COVID-19 Virus Infection in Three Patients With Hypogammaglobulinemia
title COVID-19 Virus Infection in Three Patients With Hypogammaglobulinemia
title_full COVID-19 Virus Infection in Three Patients With Hypogammaglobulinemia
title_fullStr COVID-19 Virus Infection in Three Patients With Hypogammaglobulinemia
title_full_unstemmed COVID-19 Virus Infection in Three Patients With Hypogammaglobulinemia
title_short COVID-19 Virus Infection in Three Patients With Hypogammaglobulinemia
title_sort covid-19 virus infection in three patients with hypogammaglobulinemia
topic Infectious Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231731/
https://www.ncbi.nlm.nih.gov/pubmed/34188994
http://dx.doi.org/10.7759/cureus.15256
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AT avaiyakishan covid19virusinfectioninthreepatientswithhypogammaglobulinemia
AT shahbijal covid19virusinfectioninthreepatientswithhypogammaglobulinemia
AT greenejohn covid19virusinfectioninthreepatientswithhypogammaglobulinemia

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