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Formaldehyde and De/Methylation in Age-Related Cognitive Impairment
Formaldehyde (FA) is a highly reactive substance that is ubiquitous in the environment and is usually considered as a pollutant. In the human body, FA is a product of various metabolic pathways and participates in one-carbon cycle, which provides carbon for the synthesis and modification of bio-comp...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231798/ https://www.ncbi.nlm.nih.gov/pubmed/34199279 http://dx.doi.org/10.3390/genes12060913 |
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author | Li, Ting Wei, Yan Qu, Meihua Mou, Lixian Miao, Junye Xi, Mengqi Liu, Ying He, Rongqiao |
author_facet | Li, Ting Wei, Yan Qu, Meihua Mou, Lixian Miao, Junye Xi, Mengqi Liu, Ying He, Rongqiao |
author_sort | Li, Ting |
collection | PubMed |
description | Formaldehyde (FA) is a highly reactive substance that is ubiquitous in the environment and is usually considered as a pollutant. In the human body, FA is a product of various metabolic pathways and participates in one-carbon cycle, which provides carbon for the synthesis and modification of bio-compounds, such as DNA, RNA, and amino acids. Endogenous FA plays a role in epigenetic regulation, especially in the methylation and demethylation of DNA, histones, and RNA. Recently, epigenetic alterations associated with FA dysmetabolism have been considered as one of the important features in age-related cognitive impairment (ARCI), suggesting the potential of using FA as a diagnostic biomarker of ARCI. Notably, FA plays multifaceted roles, and, at certain concentrations, it promotes cell proliferation, enhances memory formation, and elongates life span, effects that could also be involved in the aetiology of ARCI. Further investigation of and the regulation of the epigenetics landscape may provide new insights about the aetiology of ARCI and provide novel therapeutic targets. |
format | Online Article Text |
id | pubmed-8231798 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82317982021-06-26 Formaldehyde and De/Methylation in Age-Related Cognitive Impairment Li, Ting Wei, Yan Qu, Meihua Mou, Lixian Miao, Junye Xi, Mengqi Liu, Ying He, Rongqiao Genes (Basel) Review Formaldehyde (FA) is a highly reactive substance that is ubiquitous in the environment and is usually considered as a pollutant. In the human body, FA is a product of various metabolic pathways and participates in one-carbon cycle, which provides carbon for the synthesis and modification of bio-compounds, such as DNA, RNA, and amino acids. Endogenous FA plays a role in epigenetic regulation, especially in the methylation and demethylation of DNA, histones, and RNA. Recently, epigenetic alterations associated with FA dysmetabolism have been considered as one of the important features in age-related cognitive impairment (ARCI), suggesting the potential of using FA as a diagnostic biomarker of ARCI. Notably, FA plays multifaceted roles, and, at certain concentrations, it promotes cell proliferation, enhances memory formation, and elongates life span, effects that could also be involved in the aetiology of ARCI. Further investigation of and the regulation of the epigenetics landscape may provide new insights about the aetiology of ARCI and provide novel therapeutic targets. MDPI 2021-06-13 /pmc/articles/PMC8231798/ /pubmed/34199279 http://dx.doi.org/10.3390/genes12060913 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Li, Ting Wei, Yan Qu, Meihua Mou, Lixian Miao, Junye Xi, Mengqi Liu, Ying He, Rongqiao Formaldehyde and De/Methylation in Age-Related Cognitive Impairment |
title | Formaldehyde and De/Methylation in Age-Related Cognitive Impairment |
title_full | Formaldehyde and De/Methylation in Age-Related Cognitive Impairment |
title_fullStr | Formaldehyde and De/Methylation in Age-Related Cognitive Impairment |
title_full_unstemmed | Formaldehyde and De/Methylation in Age-Related Cognitive Impairment |
title_short | Formaldehyde and De/Methylation in Age-Related Cognitive Impairment |
title_sort | formaldehyde and de/methylation in age-related cognitive impairment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231798/ https://www.ncbi.nlm.nih.gov/pubmed/34199279 http://dx.doi.org/10.3390/genes12060913 |
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