Cargando…

Formaldehyde and De/Methylation in Age-Related Cognitive Impairment

Formaldehyde (FA) is a highly reactive substance that is ubiquitous in the environment and is usually considered as a pollutant. In the human body, FA is a product of various metabolic pathways and participates in one-carbon cycle, which provides carbon for the synthesis and modification of bio-comp...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Ting, Wei, Yan, Qu, Meihua, Mou, Lixian, Miao, Junye, Xi, Mengqi, Liu, Ying, He, Rongqiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231798/
https://www.ncbi.nlm.nih.gov/pubmed/34199279
http://dx.doi.org/10.3390/genes12060913
_version_ 1783713496759795712
author Li, Ting
Wei, Yan
Qu, Meihua
Mou, Lixian
Miao, Junye
Xi, Mengqi
Liu, Ying
He, Rongqiao
author_facet Li, Ting
Wei, Yan
Qu, Meihua
Mou, Lixian
Miao, Junye
Xi, Mengqi
Liu, Ying
He, Rongqiao
author_sort Li, Ting
collection PubMed
description Formaldehyde (FA) is a highly reactive substance that is ubiquitous in the environment and is usually considered as a pollutant. In the human body, FA is a product of various metabolic pathways and participates in one-carbon cycle, which provides carbon for the synthesis and modification of bio-compounds, such as DNA, RNA, and amino acids. Endogenous FA plays a role in epigenetic regulation, especially in the methylation and demethylation of DNA, histones, and RNA. Recently, epigenetic alterations associated with FA dysmetabolism have been considered as one of the important features in age-related cognitive impairment (ARCI), suggesting the potential of using FA as a diagnostic biomarker of ARCI. Notably, FA plays multifaceted roles, and, at certain concentrations, it promotes cell proliferation, enhances memory formation, and elongates life span, effects that could also be involved in the aetiology of ARCI. Further investigation of and the regulation of the epigenetics landscape may provide new insights about the aetiology of ARCI and provide novel therapeutic targets.
format Online
Article
Text
id pubmed-8231798
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-82317982021-06-26 Formaldehyde and De/Methylation in Age-Related Cognitive Impairment Li, Ting Wei, Yan Qu, Meihua Mou, Lixian Miao, Junye Xi, Mengqi Liu, Ying He, Rongqiao Genes (Basel) Review Formaldehyde (FA) is a highly reactive substance that is ubiquitous in the environment and is usually considered as a pollutant. In the human body, FA is a product of various metabolic pathways and participates in one-carbon cycle, which provides carbon for the synthesis and modification of bio-compounds, such as DNA, RNA, and amino acids. Endogenous FA plays a role in epigenetic regulation, especially in the methylation and demethylation of DNA, histones, and RNA. Recently, epigenetic alterations associated with FA dysmetabolism have been considered as one of the important features in age-related cognitive impairment (ARCI), suggesting the potential of using FA as a diagnostic biomarker of ARCI. Notably, FA plays multifaceted roles, and, at certain concentrations, it promotes cell proliferation, enhances memory formation, and elongates life span, effects that could also be involved in the aetiology of ARCI. Further investigation of and the regulation of the epigenetics landscape may provide new insights about the aetiology of ARCI and provide novel therapeutic targets. MDPI 2021-06-13 /pmc/articles/PMC8231798/ /pubmed/34199279 http://dx.doi.org/10.3390/genes12060913 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Ting
Wei, Yan
Qu, Meihua
Mou, Lixian
Miao, Junye
Xi, Mengqi
Liu, Ying
He, Rongqiao
Formaldehyde and De/Methylation in Age-Related Cognitive Impairment
title Formaldehyde and De/Methylation in Age-Related Cognitive Impairment
title_full Formaldehyde and De/Methylation in Age-Related Cognitive Impairment
title_fullStr Formaldehyde and De/Methylation in Age-Related Cognitive Impairment
title_full_unstemmed Formaldehyde and De/Methylation in Age-Related Cognitive Impairment
title_short Formaldehyde and De/Methylation in Age-Related Cognitive Impairment
title_sort formaldehyde and de/methylation in age-related cognitive impairment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231798/
https://www.ncbi.nlm.nih.gov/pubmed/34199279
http://dx.doi.org/10.3390/genes12060913
work_keys_str_mv AT liting formaldehydeanddemethylationinagerelatedcognitiveimpairment
AT weiyan formaldehydeanddemethylationinagerelatedcognitiveimpairment
AT qumeihua formaldehydeanddemethylationinagerelatedcognitiveimpairment
AT moulixian formaldehydeanddemethylationinagerelatedcognitiveimpairment
AT miaojunye formaldehydeanddemethylationinagerelatedcognitiveimpairment
AT ximengqi formaldehydeanddemethylationinagerelatedcognitiveimpairment
AT liuying formaldehydeanddemethylationinagerelatedcognitiveimpairment
AT herongqiao formaldehydeanddemethylationinagerelatedcognitiveimpairment