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Zn–0.8Mg–0.2Sr (wt.%) Absorbable Screws—An In-Vivo Biocompatibility and Degradation Pilot Study on a Rabbit Model
In this pilot study, we investigated the biocompatibility and degradation rate of an extruded Zn–0.8Mg–0.2Sr (wt.%) alloy on a rabbit model. An alloy screw was implanted into one of the tibiae of New Zealand White rabbits. After 120 days, the animals were euthanized. Evaluation included clinical ass...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231803/ https://www.ncbi.nlm.nih.gov/pubmed/34199249 http://dx.doi.org/10.3390/ma14123271 |
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author | Klíma, Karel Ulmann, Dan Bartoš, Martin Španko, Michal Dušková, Jaroslava Vrbová, Radka Pinc, Jan Kubásek, Jiří Ulmannová, Tereza Foltán, René Brizman, Eitan Drahoš, Milan Beňo, Michal Čapek, Jaroslav |
author_facet | Klíma, Karel Ulmann, Dan Bartoš, Martin Španko, Michal Dušková, Jaroslava Vrbová, Radka Pinc, Jan Kubásek, Jiří Ulmannová, Tereza Foltán, René Brizman, Eitan Drahoš, Milan Beňo, Michal Čapek, Jaroslav |
author_sort | Klíma, Karel |
collection | PubMed |
description | In this pilot study, we investigated the biocompatibility and degradation rate of an extruded Zn–0.8Mg–0.2Sr (wt.%) alloy on a rabbit model. An alloy screw was implanted into one of the tibiae of New Zealand White rabbits. After 120 days, the animals were euthanized. Evaluation included clinical assessment, microCT, histological examination of implants, analyses of the adjacent bone, and assessment of zinc, magnesium, and strontium in vital organs (liver, kidneys, brain). The bone sections with the implanted screw were examined via scanning electron microscopy and energy dispersive spectroscopy (SEM-EDS). This method showed that the implant was covered by a thin layer of phosphate-based solid corrosion products with a thickness ranging between 4 and 5 µm. Only negligible changes of the implant volume and area were observed. The degradation was not connected with gas evolution. The screws were fibrointegrated, partially osseointegrated histologically. We observed no inflammatory reaction or bone resorption. Periosteal apposition and formation of new bone with a regular structure were frequently observed near the implant surface. The histological evaluation of the liver, kidneys, and brain showed no toxic changes. The levels of Zn, Mg, and Sr after 120 days in the liver, kidneys, and brain did not exceed the reference values for these elements. The alloy was safe, biocompatible, and well-tolerated. |
format | Online Article Text |
id | pubmed-8231803 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82318032021-06-26 Zn–0.8Mg–0.2Sr (wt.%) Absorbable Screws—An In-Vivo Biocompatibility and Degradation Pilot Study on a Rabbit Model Klíma, Karel Ulmann, Dan Bartoš, Martin Španko, Michal Dušková, Jaroslava Vrbová, Radka Pinc, Jan Kubásek, Jiří Ulmannová, Tereza Foltán, René Brizman, Eitan Drahoš, Milan Beňo, Michal Čapek, Jaroslav Materials (Basel) Article In this pilot study, we investigated the biocompatibility and degradation rate of an extruded Zn–0.8Mg–0.2Sr (wt.%) alloy on a rabbit model. An alloy screw was implanted into one of the tibiae of New Zealand White rabbits. After 120 days, the animals were euthanized. Evaluation included clinical assessment, microCT, histological examination of implants, analyses of the adjacent bone, and assessment of zinc, magnesium, and strontium in vital organs (liver, kidneys, brain). The bone sections with the implanted screw were examined via scanning electron microscopy and energy dispersive spectroscopy (SEM-EDS). This method showed that the implant was covered by a thin layer of phosphate-based solid corrosion products with a thickness ranging between 4 and 5 µm. Only negligible changes of the implant volume and area were observed. The degradation was not connected with gas evolution. The screws were fibrointegrated, partially osseointegrated histologically. We observed no inflammatory reaction or bone resorption. Periosteal apposition and formation of new bone with a regular structure were frequently observed near the implant surface. The histological evaluation of the liver, kidneys, and brain showed no toxic changes. The levels of Zn, Mg, and Sr after 120 days in the liver, kidneys, and brain did not exceed the reference values for these elements. The alloy was safe, biocompatible, and well-tolerated. MDPI 2021-06-13 /pmc/articles/PMC8231803/ /pubmed/34199249 http://dx.doi.org/10.3390/ma14123271 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Klíma, Karel Ulmann, Dan Bartoš, Martin Španko, Michal Dušková, Jaroslava Vrbová, Radka Pinc, Jan Kubásek, Jiří Ulmannová, Tereza Foltán, René Brizman, Eitan Drahoš, Milan Beňo, Michal Čapek, Jaroslav Zn–0.8Mg–0.2Sr (wt.%) Absorbable Screws—An In-Vivo Biocompatibility and Degradation Pilot Study on a Rabbit Model |
title | Zn–0.8Mg–0.2Sr (wt.%) Absorbable Screws—An In-Vivo Biocompatibility and Degradation Pilot Study on a Rabbit Model |
title_full | Zn–0.8Mg–0.2Sr (wt.%) Absorbable Screws—An In-Vivo Biocompatibility and Degradation Pilot Study on a Rabbit Model |
title_fullStr | Zn–0.8Mg–0.2Sr (wt.%) Absorbable Screws—An In-Vivo Biocompatibility and Degradation Pilot Study on a Rabbit Model |
title_full_unstemmed | Zn–0.8Mg–0.2Sr (wt.%) Absorbable Screws—An In-Vivo Biocompatibility and Degradation Pilot Study on a Rabbit Model |
title_short | Zn–0.8Mg–0.2Sr (wt.%) Absorbable Screws—An In-Vivo Biocompatibility and Degradation Pilot Study on a Rabbit Model |
title_sort | zn–0.8mg–0.2sr (wt.%) absorbable screws—an in-vivo biocompatibility and degradation pilot study on a rabbit model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231803/ https://www.ncbi.nlm.nih.gov/pubmed/34199249 http://dx.doi.org/10.3390/ma14123271 |
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