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Six New Diterpene Glycosides from the Soft Coral Lemnalia bournei
A chemical study on the extracts of soft coral Lemnalia bournei resulted in the isolation and identification of six new bicyclic diterpene glycosides including three new lemnaboursides E–G (1–3), and three new lemnadiolboursides A–C (4–6), along with three known lemnaboursides (7–9). Their structure...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231804/ https://www.ncbi.nlm.nih.gov/pubmed/34198505 http://dx.doi.org/10.3390/md19060339 |
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author | Yan, Xia Ouyang, Han Li, Te Shi, Yutong Wu, Bin Yan, Xiaojun He, Shan |
author_facet | Yan, Xia Ouyang, Han Li, Te Shi, Yutong Wu, Bin Yan, Xiaojun He, Shan |
author_sort | Yan, Xia |
collection | PubMed |
description | A chemical study on the extracts of soft coral Lemnalia bournei resulted in the isolation and identification of six new bicyclic diterpene glycosides including three new lemnaboursides E–G (1–3), and three new lemnadiolboursides A–C (4–6), along with three known lemnaboursides (7–9). Their structures were elucidated by detailed spectroscopic analysis, ECD analysis, chemical methods, and comparison with the literature data. Lemnadiolboursides A–C (4–6) contained a lemnal-1(10)-ene-7,12-diol moiety compared with the lemnaboursides. All these compounds were evaluated for antibacterial activity; cell growth inhibition of A549, Hela, HepG2, and CCRF-CEM cancer cell lines; and inhibition of LPS-induced NO production in RAW264.7 macrophages. The results indicated that compounds 1, 2, and 4–6 exhibited antibacterial activity against Staphylococcus aureus and Bacillus subtilis (MIC 4–16 μg/mL); compounds 1–9 displayed low cytotoxicity on the CCRF-CEM cell lines (IC(50) 10.44–27.40 µM); and compounds 1, 2, and 5 showed weak inhibition against LPS-induced NO production (IC(50) 21.56–28.06 μM). |
format | Online Article Text |
id | pubmed-8231804 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82318042021-06-26 Six New Diterpene Glycosides from the Soft Coral Lemnalia bournei Yan, Xia Ouyang, Han Li, Te Shi, Yutong Wu, Bin Yan, Xiaojun He, Shan Mar Drugs Article A chemical study on the extracts of soft coral Lemnalia bournei resulted in the isolation and identification of six new bicyclic diterpene glycosides including three new lemnaboursides E–G (1–3), and three new lemnadiolboursides A–C (4–6), along with three known lemnaboursides (7–9). Their structures were elucidated by detailed spectroscopic analysis, ECD analysis, chemical methods, and comparison with the literature data. Lemnadiolboursides A–C (4–6) contained a lemnal-1(10)-ene-7,12-diol moiety compared with the lemnaboursides. All these compounds were evaluated for antibacterial activity; cell growth inhibition of A549, Hela, HepG2, and CCRF-CEM cancer cell lines; and inhibition of LPS-induced NO production in RAW264.7 macrophages. The results indicated that compounds 1, 2, and 4–6 exhibited antibacterial activity against Staphylococcus aureus and Bacillus subtilis (MIC 4–16 μg/mL); compounds 1–9 displayed low cytotoxicity on the CCRF-CEM cell lines (IC(50) 10.44–27.40 µM); and compounds 1, 2, and 5 showed weak inhibition against LPS-induced NO production (IC(50) 21.56–28.06 μM). MDPI 2021-06-14 /pmc/articles/PMC8231804/ /pubmed/34198505 http://dx.doi.org/10.3390/md19060339 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yan, Xia Ouyang, Han Li, Te Shi, Yutong Wu, Bin Yan, Xiaojun He, Shan Six New Diterpene Glycosides from the Soft Coral Lemnalia bournei |
title | Six New Diterpene Glycosides from the Soft Coral Lemnalia
bournei |
title_full | Six New Diterpene Glycosides from the Soft Coral Lemnalia
bournei |
title_fullStr | Six New Diterpene Glycosides from the Soft Coral Lemnalia
bournei |
title_full_unstemmed | Six New Diterpene Glycosides from the Soft Coral Lemnalia
bournei |
title_short | Six New Diterpene Glycosides from the Soft Coral Lemnalia
bournei |
title_sort | six new diterpene glycosides from the soft coral lemnalia
bournei |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231804/ https://www.ncbi.nlm.nih.gov/pubmed/34198505 http://dx.doi.org/10.3390/md19060339 |
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