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Towards a Better Understanding of the Relationships between Galectin-7, p53 and MMP-9 during Cancer Progression

It has been almost 25 years since the discovery of galectin-7. This member of the galectin family has attracted interest from many working in the cancer field given its highly restricted expression profile in epithelial cells and the fact that cancers of epithelial origin (carcinoma) are among the m...

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Autor principal: St-Pierre, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231854/
https://www.ncbi.nlm.nih.gov/pubmed/34198494
http://dx.doi.org/10.3390/biom11060879
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author St-Pierre, Yves
author_facet St-Pierre, Yves
author_sort St-Pierre, Yves
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description It has been almost 25 years since the discovery of galectin-7. This member of the galectin family has attracted interest from many working in the cancer field given its highly restricted expression profile in epithelial cells and the fact that cancers of epithelial origin (carcinoma) are among the most frequent and deadly cancer subtypes. Initially described as a p53-induced gene and associated with apoptosis, galectin-7 is now recognized as having a protumorigenic role in many cancer types. Several studies have indeed shown that galectin-7 is associated with aggressive behavior of cancer cells and induces expression of MMP-9, a member of the matrix metalloproteinases (MMP) family known to confer invasive behavior to cancer cells. It is therefore not surprising that many studies have examined its relationships with p53 and MMP-9. However, the relationships between galectin-7 and p53 and MMP-9 are not always clear. This is largely because p53 is often mutated in cancer cells and such mutations drastically change its functions and, consequently, its association with galectin-7. In this review, we discuss the functional relationships between galectin-7, p53 and MMP-9 and reconcile some apparently contradictory observations. A better understanding of these relationships will help to develop a working hypothesis and model that will provide the basis for further research in the hope of establishing a new paradigm for tackling the role of galectin-7 in cancer.
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spelling pubmed-82318542021-06-26 Towards a Better Understanding of the Relationships between Galectin-7, p53 and MMP-9 during Cancer Progression St-Pierre, Yves Biomolecules Review It has been almost 25 years since the discovery of galectin-7. This member of the galectin family has attracted interest from many working in the cancer field given its highly restricted expression profile in epithelial cells and the fact that cancers of epithelial origin (carcinoma) are among the most frequent and deadly cancer subtypes. Initially described as a p53-induced gene and associated with apoptosis, galectin-7 is now recognized as having a protumorigenic role in many cancer types. Several studies have indeed shown that galectin-7 is associated with aggressive behavior of cancer cells and induces expression of MMP-9, a member of the matrix metalloproteinases (MMP) family known to confer invasive behavior to cancer cells. It is therefore not surprising that many studies have examined its relationships with p53 and MMP-9. However, the relationships between galectin-7 and p53 and MMP-9 are not always clear. This is largely because p53 is often mutated in cancer cells and such mutations drastically change its functions and, consequently, its association with galectin-7. In this review, we discuss the functional relationships between galectin-7, p53 and MMP-9 and reconcile some apparently contradictory observations. A better understanding of these relationships will help to develop a working hypothesis and model that will provide the basis for further research in the hope of establishing a new paradigm for tackling the role of galectin-7 in cancer. MDPI 2021-06-14 /pmc/articles/PMC8231854/ /pubmed/34198494 http://dx.doi.org/10.3390/biom11060879 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
St-Pierre, Yves
Towards a Better Understanding of the Relationships between Galectin-7, p53 and MMP-9 during Cancer Progression
title Towards a Better Understanding of the Relationships between Galectin-7, p53 and MMP-9 during Cancer Progression
title_full Towards a Better Understanding of the Relationships between Galectin-7, p53 and MMP-9 during Cancer Progression
title_fullStr Towards a Better Understanding of the Relationships between Galectin-7, p53 and MMP-9 during Cancer Progression
title_full_unstemmed Towards a Better Understanding of the Relationships between Galectin-7, p53 and MMP-9 during Cancer Progression
title_short Towards a Better Understanding of the Relationships between Galectin-7, p53 and MMP-9 during Cancer Progression
title_sort towards a better understanding of the relationships between galectin-7, p53 and mmp-9 during cancer progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231854/
https://www.ncbi.nlm.nih.gov/pubmed/34198494
http://dx.doi.org/10.3390/biom11060879
work_keys_str_mv AT stpierreyves towardsabetterunderstandingoftherelationshipsbetweengalectin7p53andmmp9duringcancerprogression