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Endothelial Cell Participation in Inflammatory Reaction

Inflammation is an old concept that has started to be considered as an important factor in infection and chronic diseases. The role of leukocytes, the plasmatic components, then of the mediators such as prostaglandins, cytokines, and, in recent decades, of the endothelium has completed the concept o...

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Autores principales: Wautier, Jean-Luc, Wautier, Marie-Paule
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231964/
https://www.ncbi.nlm.nih.gov/pubmed/34199319
http://dx.doi.org/10.3390/ijms22126341
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author Wautier, Jean-Luc
Wautier, Marie-Paule
author_facet Wautier, Jean-Luc
Wautier, Marie-Paule
author_sort Wautier, Jean-Luc
collection PubMed
description Inflammation is an old concept that has started to be considered as an important factor in infection and chronic diseases. The role of leukocytes, the plasmatic components, then of the mediators such as prostaglandins, cytokines, and, in recent decades, of the endothelium has completed the concept of the inflammation process. The function of the endothelium appeared to be crucial as a regulator or the initiator of the inflammatory process. Culture of human endothelial cells and experimental systems made it possible to define the molecular basis of inflammation in vascular diseases, in diabetes mellitus, atherosclerosis, vasculitis and thromboembolic complications. Advanced glycation end product receptor (RAGE), present on endothelial cells (ECs) and monocytes, participates in the activation of these cells in inflammatory conditions. Inflammasome is a cytosolic multiprotein that controls the response to diverse microorganisms. It is positively regulated by stimulator of interferon response CGAMP interactor-1 (STING1). Angiogenesis and thrombotic events are dysregulated during inflammation. ECs appear to be a protector, but also a possible initiator of thrombosis.
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spelling pubmed-82319642021-06-26 Endothelial Cell Participation in Inflammatory Reaction Wautier, Jean-Luc Wautier, Marie-Paule Int J Mol Sci Review Inflammation is an old concept that has started to be considered as an important factor in infection and chronic diseases. The role of leukocytes, the plasmatic components, then of the mediators such as prostaglandins, cytokines, and, in recent decades, of the endothelium has completed the concept of the inflammation process. The function of the endothelium appeared to be crucial as a regulator or the initiator of the inflammatory process. Culture of human endothelial cells and experimental systems made it possible to define the molecular basis of inflammation in vascular diseases, in diabetes mellitus, atherosclerosis, vasculitis and thromboembolic complications. Advanced glycation end product receptor (RAGE), present on endothelial cells (ECs) and monocytes, participates in the activation of these cells in inflammatory conditions. Inflammasome is a cytosolic multiprotein that controls the response to diverse microorganisms. It is positively regulated by stimulator of interferon response CGAMP interactor-1 (STING1). Angiogenesis and thrombotic events are dysregulated during inflammation. ECs appear to be a protector, but also a possible initiator of thrombosis. MDPI 2021-06-13 /pmc/articles/PMC8231964/ /pubmed/34199319 http://dx.doi.org/10.3390/ijms22126341 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wautier, Jean-Luc
Wautier, Marie-Paule
Endothelial Cell Participation in Inflammatory Reaction
title Endothelial Cell Participation in Inflammatory Reaction
title_full Endothelial Cell Participation in Inflammatory Reaction
title_fullStr Endothelial Cell Participation in Inflammatory Reaction
title_full_unstemmed Endothelial Cell Participation in Inflammatory Reaction
title_short Endothelial Cell Participation in Inflammatory Reaction
title_sort endothelial cell participation in inflammatory reaction
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231964/
https://www.ncbi.nlm.nih.gov/pubmed/34199319
http://dx.doi.org/10.3390/ijms22126341
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