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Potential Biomarkers for Treatment Response to the BCL-2 Inhibitor Venetoclax: State of the Art and Future Directions

SIMPLE SUMMARY: Apoptosis dysergulation is vital to oncogenesis. Efforts to mitigate this cancer hallmark have been ongoing for decades, focused mostly on inhibiting BCL-2, a key anti-apoptosis effector. The approval of venetoclax, a selective BCL-2 inhibitor, for clinical use has been a turning poi...

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Detalles Bibliográficos
Autores principales:	Salah, Haneen T., DiNardo, Courtney D., Konopleva, Marina, Khoury, Joseph D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231978/ https://www.ncbi.nlm.nih.gov/pubmed/34198580 http://dx.doi.org/10.3390/cancers13122974

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