Changes in the Pharmacokinetics and Pharmacodynamics of Sildenafil in Cigarette and Cannabis Smokers

Sildenafil citrate, a widely-used oral therapy for erectile dysfunction, is a cytochrome P3A4 (CYP3A4) enzyme substrate. Studies have reported that this substrate has an inhibitory effect on CYP3A4 enzymes in long-term cigarette and cannabis smokers, which predominantly mediate the hepatic eliminati...

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Detalles Bibliográficos
Autores principales: Murtadha, Mohammed, Raslan, Mohamed Ahmed, Fahmy, Sarah Farid, Sabri, Nagwa Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231986/
https://www.ncbi.nlm.nih.gov/pubmed/34199328
http://dx.doi.org/10.3390/pharmaceutics13060876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231986/
https://www.ncbi.nlm.nih.gov/pubmed/34199328
http://dx.doi.org/10.3390/pharmaceutics13060876

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