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Changes in the Pharmacokinetics and Pharmacodynamics of Sildenafil in Cigarette and Cannabis Smokers

Sildenafil citrate, a widely-used oral therapy for erectile dysfunction, is a cytochrome P3A4 (CYP3A4) enzyme substrate. Studies have reported that this substrate has an inhibitory effect on CYP3A4 enzymes in long-term cigarette and cannabis smokers, which predominantly mediate the hepatic eliminati...

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Detalles Bibliográficos
Autores principales:	Murtadha, Mohammed, Raslan, Mohamed Ahmed, Fahmy, Sarah Farid, Sabri, Nagwa Ali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231986/ https://www.ncbi.nlm.nih.gov/pubmed/34199328 http://dx.doi.org/10.3390/pharmaceutics13060876

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