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White Spot, a Novel Endoscopic Finding, May Be Associated with Acid-Suppressing Agents and Hypergastrinemia
White globe appearance (WGA) is defined as a microendoscopic white lesion with a globular shape underlying the gastric epithelium and is considered a marker of gastric cancer. We recently reported that endoscopically visualized white spot (WS) corresponding to WGA appeared on the nonatrophic mucosa...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232144/ https://www.ncbi.nlm.nih.gov/pubmed/34203619 http://dx.doi.org/10.3390/jcm10122625 |
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author | Nishiyama, Noriko Kobara, Hideki Ayaki, Maki Fujihara, Shintaro Nakatani, Kaho Tada, Naoya Koduka, Kazuhiro Matsui, Takanori Takata, Tadayuki Chiyo, Taiga Kobayashi, Nobuya Shi, Tingting Fujita, Koji Tani, Joji Yachida, Tatsuo Masaki, Tsutomu Haruma, Ken |
author_facet | Nishiyama, Noriko Kobara, Hideki Ayaki, Maki Fujihara, Shintaro Nakatani, Kaho Tada, Naoya Koduka, Kazuhiro Matsui, Takanori Takata, Tadayuki Chiyo, Taiga Kobayashi, Nobuya Shi, Tingting Fujita, Koji Tani, Joji Yachida, Tatsuo Masaki, Tsutomu Haruma, Ken |
author_sort | Nishiyama, Noriko |
collection | PubMed |
description | White globe appearance (WGA) is defined as a microendoscopic white lesion with a globular shape underlying the gastric epithelium and is considered a marker of gastric cancer. We recently reported that endoscopically visualized white spot (WS) corresponding to WGA appeared on the nonatrophic mucosa of patients with acid-suppressing agents (A-SA) use. We evaluated patients undergoing routine esophagogastroduodenoscopy and divided the patients into an A-SA group (n = 112) and a control group (n = 158). We compared the presence of WS in both groups. We also compared WS-positive- (n = 31) and -negative (n = 43) groups within the A-SA group regarding these patients’ backgrounds and serum gastrin concentrations. Comparing the A-SA group with controls, the prevalence of WS was significantly higher (31/112 vs. 2/158; p < 0.001). The number of patients with high serum gastrin concentrations was significantly higher in the WS-positive group (18/31) vs. the WS-negative group (5/43) (p < 0.001). Within the A-SA group, the prevalence of WS was also significantly higher in patients taking potassium-competitive acid blockers vs. proton-pump inhibitors (21/31 vs. 10/31, p < 0.001). The WS-positive group had a significantly greater percentage of patients, with a high serum gastrin level (p < 0.001). WS may be associated with hypergastrinemia and potassium-competitive acid blockers. |
format | Online Article Text |
id | pubmed-8232144 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82321442021-06-26 White Spot, a Novel Endoscopic Finding, May Be Associated with Acid-Suppressing Agents and Hypergastrinemia Nishiyama, Noriko Kobara, Hideki Ayaki, Maki Fujihara, Shintaro Nakatani, Kaho Tada, Naoya Koduka, Kazuhiro Matsui, Takanori Takata, Tadayuki Chiyo, Taiga Kobayashi, Nobuya Shi, Tingting Fujita, Koji Tani, Joji Yachida, Tatsuo Masaki, Tsutomu Haruma, Ken J Clin Med Article White globe appearance (WGA) is defined as a microendoscopic white lesion with a globular shape underlying the gastric epithelium and is considered a marker of gastric cancer. We recently reported that endoscopically visualized white spot (WS) corresponding to WGA appeared on the nonatrophic mucosa of patients with acid-suppressing agents (A-SA) use. We evaluated patients undergoing routine esophagogastroduodenoscopy and divided the patients into an A-SA group (n = 112) and a control group (n = 158). We compared the presence of WS in both groups. We also compared WS-positive- (n = 31) and -negative (n = 43) groups within the A-SA group regarding these patients’ backgrounds and serum gastrin concentrations. Comparing the A-SA group with controls, the prevalence of WS was significantly higher (31/112 vs. 2/158; p < 0.001). The number of patients with high serum gastrin concentrations was significantly higher in the WS-positive group (18/31) vs. the WS-negative group (5/43) (p < 0.001). Within the A-SA group, the prevalence of WS was also significantly higher in patients taking potassium-competitive acid blockers vs. proton-pump inhibitors (21/31 vs. 10/31, p < 0.001). The WS-positive group had a significantly greater percentage of patients, with a high serum gastrin level (p < 0.001). WS may be associated with hypergastrinemia and potassium-competitive acid blockers. MDPI 2021-06-15 /pmc/articles/PMC8232144/ /pubmed/34203619 http://dx.doi.org/10.3390/jcm10122625 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Nishiyama, Noriko Kobara, Hideki Ayaki, Maki Fujihara, Shintaro Nakatani, Kaho Tada, Naoya Koduka, Kazuhiro Matsui, Takanori Takata, Tadayuki Chiyo, Taiga Kobayashi, Nobuya Shi, Tingting Fujita, Koji Tani, Joji Yachida, Tatsuo Masaki, Tsutomu Haruma, Ken White Spot, a Novel Endoscopic Finding, May Be Associated with Acid-Suppressing Agents and Hypergastrinemia |
title | White Spot, a Novel Endoscopic Finding, May Be Associated with Acid-Suppressing Agents and Hypergastrinemia |
title_full | White Spot, a Novel Endoscopic Finding, May Be Associated with Acid-Suppressing Agents and Hypergastrinemia |
title_fullStr | White Spot, a Novel Endoscopic Finding, May Be Associated with Acid-Suppressing Agents and Hypergastrinemia |
title_full_unstemmed | White Spot, a Novel Endoscopic Finding, May Be Associated with Acid-Suppressing Agents and Hypergastrinemia |
title_short | White Spot, a Novel Endoscopic Finding, May Be Associated with Acid-Suppressing Agents and Hypergastrinemia |
title_sort | white spot, a novel endoscopic finding, may be associated with acid-suppressing agents and hypergastrinemia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232144/ https://www.ncbi.nlm.nih.gov/pubmed/34203619 http://dx.doi.org/10.3390/jcm10122625 |
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