Cargando…

White Spot, a Novel Endoscopic Finding, May Be Associated with Acid-Suppressing Agents and Hypergastrinemia

White globe appearance (WGA) is defined as a microendoscopic white lesion with a globular shape underlying the gastric epithelium and is considered a marker of gastric cancer. We recently reported that endoscopically visualized white spot (WS) corresponding to WGA appeared on the nonatrophic mucosa...

Descripción completa

Detalles Bibliográficos
Autores principales: Nishiyama, Noriko, Kobara, Hideki, Ayaki, Maki, Fujihara, Shintaro, Nakatani, Kaho, Tada, Naoya, Koduka, Kazuhiro, Matsui, Takanori, Takata, Tadayuki, Chiyo, Taiga, Kobayashi, Nobuya, Shi, Tingting, Fujita, Koji, Tani, Joji, Yachida, Tatsuo, Masaki, Tsutomu, Haruma, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232144/
https://www.ncbi.nlm.nih.gov/pubmed/34203619
http://dx.doi.org/10.3390/jcm10122625
_version_ 1783713573013291008
author Nishiyama, Noriko
Kobara, Hideki
Ayaki, Maki
Fujihara, Shintaro
Nakatani, Kaho
Tada, Naoya
Koduka, Kazuhiro
Matsui, Takanori
Takata, Tadayuki
Chiyo, Taiga
Kobayashi, Nobuya
Shi, Tingting
Fujita, Koji
Tani, Joji
Yachida, Tatsuo
Masaki, Tsutomu
Haruma, Ken
author_facet Nishiyama, Noriko
Kobara, Hideki
Ayaki, Maki
Fujihara, Shintaro
Nakatani, Kaho
Tada, Naoya
Koduka, Kazuhiro
Matsui, Takanori
Takata, Tadayuki
Chiyo, Taiga
Kobayashi, Nobuya
Shi, Tingting
Fujita, Koji
Tani, Joji
Yachida, Tatsuo
Masaki, Tsutomu
Haruma, Ken
author_sort Nishiyama, Noriko
collection PubMed
description White globe appearance (WGA) is defined as a microendoscopic white lesion with a globular shape underlying the gastric epithelium and is considered a marker of gastric cancer. We recently reported that endoscopically visualized white spot (WS) corresponding to WGA appeared on the nonatrophic mucosa of patients with acid-suppressing agents (A-SA) use. We evaluated patients undergoing routine esophagogastroduodenoscopy and divided the patients into an A-SA group (n = 112) and a control group (n = 158). We compared the presence of WS in both groups. We also compared WS-positive- (n = 31) and -negative (n = 43) groups within the A-SA group regarding these patients’ backgrounds and serum gastrin concentrations. Comparing the A-SA group with controls, the prevalence of WS was significantly higher (31/112 vs. 2/158; p < 0.001). The number of patients with high serum gastrin concentrations was significantly higher in the WS-positive group (18/31) vs. the WS-negative group (5/43) (p < 0.001). Within the A-SA group, the prevalence of WS was also significantly higher in patients taking potassium-competitive acid blockers vs. proton-pump inhibitors (21/31 vs. 10/31, p < 0.001). The WS-positive group had a significantly greater percentage of patients, with a high serum gastrin level (p < 0.001). WS may be associated with hypergastrinemia and potassium-competitive acid blockers.
format Online
Article
Text
id pubmed-8232144
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-82321442021-06-26 White Spot, a Novel Endoscopic Finding, May Be Associated with Acid-Suppressing Agents and Hypergastrinemia Nishiyama, Noriko Kobara, Hideki Ayaki, Maki Fujihara, Shintaro Nakatani, Kaho Tada, Naoya Koduka, Kazuhiro Matsui, Takanori Takata, Tadayuki Chiyo, Taiga Kobayashi, Nobuya Shi, Tingting Fujita, Koji Tani, Joji Yachida, Tatsuo Masaki, Tsutomu Haruma, Ken J Clin Med Article White globe appearance (WGA) is defined as a microendoscopic white lesion with a globular shape underlying the gastric epithelium and is considered a marker of gastric cancer. We recently reported that endoscopically visualized white spot (WS) corresponding to WGA appeared on the nonatrophic mucosa of patients with acid-suppressing agents (A-SA) use. We evaluated patients undergoing routine esophagogastroduodenoscopy and divided the patients into an A-SA group (n = 112) and a control group (n = 158). We compared the presence of WS in both groups. We also compared WS-positive- (n = 31) and -negative (n = 43) groups within the A-SA group regarding these patients’ backgrounds and serum gastrin concentrations. Comparing the A-SA group with controls, the prevalence of WS was significantly higher (31/112 vs. 2/158; p < 0.001). The number of patients with high serum gastrin concentrations was significantly higher in the WS-positive group (18/31) vs. the WS-negative group (5/43) (p < 0.001). Within the A-SA group, the prevalence of WS was also significantly higher in patients taking potassium-competitive acid blockers vs. proton-pump inhibitors (21/31 vs. 10/31, p < 0.001). The WS-positive group had a significantly greater percentage of patients, with a high serum gastrin level (p < 0.001). WS may be associated with hypergastrinemia and potassium-competitive acid blockers. MDPI 2021-06-15 /pmc/articles/PMC8232144/ /pubmed/34203619 http://dx.doi.org/10.3390/jcm10122625 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nishiyama, Noriko
Kobara, Hideki
Ayaki, Maki
Fujihara, Shintaro
Nakatani, Kaho
Tada, Naoya
Koduka, Kazuhiro
Matsui, Takanori
Takata, Tadayuki
Chiyo, Taiga
Kobayashi, Nobuya
Shi, Tingting
Fujita, Koji
Tani, Joji
Yachida, Tatsuo
Masaki, Tsutomu
Haruma, Ken
White Spot, a Novel Endoscopic Finding, May Be Associated with Acid-Suppressing Agents and Hypergastrinemia
title White Spot, a Novel Endoscopic Finding, May Be Associated with Acid-Suppressing Agents and Hypergastrinemia
title_full White Spot, a Novel Endoscopic Finding, May Be Associated with Acid-Suppressing Agents and Hypergastrinemia
title_fullStr White Spot, a Novel Endoscopic Finding, May Be Associated with Acid-Suppressing Agents and Hypergastrinemia
title_full_unstemmed White Spot, a Novel Endoscopic Finding, May Be Associated with Acid-Suppressing Agents and Hypergastrinemia
title_short White Spot, a Novel Endoscopic Finding, May Be Associated with Acid-Suppressing Agents and Hypergastrinemia
title_sort white spot, a novel endoscopic finding, may be associated with acid-suppressing agents and hypergastrinemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232144/
https://www.ncbi.nlm.nih.gov/pubmed/34203619
http://dx.doi.org/10.3390/jcm10122625
work_keys_str_mv AT nishiyamanoriko whitespotanovelendoscopicfindingmaybeassociatedwithacidsuppressingagentsandhypergastrinemia
AT kobarahideki whitespotanovelendoscopicfindingmaybeassociatedwithacidsuppressingagentsandhypergastrinemia
AT ayakimaki whitespotanovelendoscopicfindingmaybeassociatedwithacidsuppressingagentsandhypergastrinemia
AT fujiharashintaro whitespotanovelendoscopicfindingmaybeassociatedwithacidsuppressingagentsandhypergastrinemia
AT nakatanikaho whitespotanovelendoscopicfindingmaybeassociatedwithacidsuppressingagentsandhypergastrinemia
AT tadanaoya whitespotanovelendoscopicfindingmaybeassociatedwithacidsuppressingagentsandhypergastrinemia
AT kodukakazuhiro whitespotanovelendoscopicfindingmaybeassociatedwithacidsuppressingagentsandhypergastrinemia
AT matsuitakanori whitespotanovelendoscopicfindingmaybeassociatedwithacidsuppressingagentsandhypergastrinemia
AT takatatadayuki whitespotanovelendoscopicfindingmaybeassociatedwithacidsuppressingagentsandhypergastrinemia
AT chiyotaiga whitespotanovelendoscopicfindingmaybeassociatedwithacidsuppressingagentsandhypergastrinemia
AT kobayashinobuya whitespotanovelendoscopicfindingmaybeassociatedwithacidsuppressingagentsandhypergastrinemia
AT shitingting whitespotanovelendoscopicfindingmaybeassociatedwithacidsuppressingagentsandhypergastrinemia
AT fujitakoji whitespotanovelendoscopicfindingmaybeassociatedwithacidsuppressingagentsandhypergastrinemia
AT tanijoji whitespotanovelendoscopicfindingmaybeassociatedwithacidsuppressingagentsandhypergastrinemia
AT yachidatatsuo whitespotanovelendoscopicfindingmaybeassociatedwithacidsuppressingagentsandhypergastrinemia
AT masakitsutomu whitespotanovelendoscopicfindingmaybeassociatedwithacidsuppressingagentsandhypergastrinemia
AT harumaken whitespotanovelendoscopicfindingmaybeassociatedwithacidsuppressingagentsandhypergastrinemia