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pHEMA: An Overview for Biomedical Applications

Poly(2-hydroxyethyl methacrylate) (pHEMA) as a biomaterial with excellent biocompatibility and cytocompatibility elicits a minimal immunological response from host tissue making it desirable for different biomedical applications. This article seeks to provide an in-depth overview of the properties a...

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Autores principales: Zare, Mina, Bigham, Ashkan, Zare, Mohamad, Luo, Hongrong, Rezvani Ghomi, Erfan, Ramakrishna, Seeram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232190/
https://www.ncbi.nlm.nih.gov/pubmed/34203608
http://dx.doi.org/10.3390/ijms22126376
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author Zare, Mina
Bigham, Ashkan
Zare, Mohamad
Luo, Hongrong
Rezvani Ghomi, Erfan
Ramakrishna, Seeram
author_facet Zare, Mina
Bigham, Ashkan
Zare, Mohamad
Luo, Hongrong
Rezvani Ghomi, Erfan
Ramakrishna, Seeram
author_sort Zare, Mina
collection PubMed
description Poly(2-hydroxyethyl methacrylate) (pHEMA) as a biomaterial with excellent biocompatibility and cytocompatibility elicits a minimal immunological response from host tissue making it desirable for different biomedical applications. This article seeks to provide an in-depth overview of the properties and biomedical applications of pHEMA for bone tissue regeneration, wound healing, cancer therapy (stimuli and non-stimuli responsive systems), and ophthalmic applications (contact lenses and ocular drug delivery). As this polymer has been widely applied in ophthalmic applications, a specific consideration has been devoted to this field. Pure pHEMA does not possess antimicrobial properties and the site where the biomedical device is employed may be susceptible to microbial infections. Therefore, antimicrobial strategies such as the use of silver nanoparticles, antibiotics, and antimicrobial agents can be utilized to protect against infections. Therefore, the antimicrobial strategies besides the drug delivery applications of pHEMA were covered. With continuous research and advancement in science and technology, the outlook of pHEMA is promising as it will most certainly be utilized in more biomedical applications in the near future. The aim of this review was to bring together state-of-the-art research on pHEMA and their applications.
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spelling pubmed-82321902021-06-26 pHEMA: An Overview for Biomedical Applications Zare, Mina Bigham, Ashkan Zare, Mohamad Luo, Hongrong Rezvani Ghomi, Erfan Ramakrishna, Seeram Int J Mol Sci Review Poly(2-hydroxyethyl methacrylate) (pHEMA) as a biomaterial with excellent biocompatibility and cytocompatibility elicits a minimal immunological response from host tissue making it desirable for different biomedical applications. This article seeks to provide an in-depth overview of the properties and biomedical applications of pHEMA for bone tissue regeneration, wound healing, cancer therapy (stimuli and non-stimuli responsive systems), and ophthalmic applications (contact lenses and ocular drug delivery). As this polymer has been widely applied in ophthalmic applications, a specific consideration has been devoted to this field. Pure pHEMA does not possess antimicrobial properties and the site where the biomedical device is employed may be susceptible to microbial infections. Therefore, antimicrobial strategies such as the use of silver nanoparticles, antibiotics, and antimicrobial agents can be utilized to protect against infections. Therefore, the antimicrobial strategies besides the drug delivery applications of pHEMA were covered. With continuous research and advancement in science and technology, the outlook of pHEMA is promising as it will most certainly be utilized in more biomedical applications in the near future. The aim of this review was to bring together state-of-the-art research on pHEMA and their applications. MDPI 2021-06-15 /pmc/articles/PMC8232190/ /pubmed/34203608 http://dx.doi.org/10.3390/ijms22126376 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zare, Mina
Bigham, Ashkan
Zare, Mohamad
Luo, Hongrong
Rezvani Ghomi, Erfan
Ramakrishna, Seeram
pHEMA: An Overview for Biomedical Applications
title pHEMA: An Overview for Biomedical Applications
title_full pHEMA: An Overview for Biomedical Applications
title_fullStr pHEMA: An Overview for Biomedical Applications
title_full_unstemmed pHEMA: An Overview for Biomedical Applications
title_short pHEMA: An Overview for Biomedical Applications
title_sort phema: an overview for biomedical applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232190/
https://www.ncbi.nlm.nih.gov/pubmed/34203608
http://dx.doi.org/10.3390/ijms22126376
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