Direct Amidation to Access 3-Amido-1,8-Naphthalimides Including Fluorescent Scriptaid Analogues as HDAC Inhibitors

Methodology to access fluorescent 3-amido-1,8-naphthalimides using direct Buchwald–Hartwig amidation is described. The protocol was successfully used to couple a number of substrates (including an alkylamide, an arylamide, a lactam and a carbamate) to 3-bromo-1,8-naphthalimide in good yield. To furt...

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Detalles Bibliográficos
Autores principales: Hearn, Kyle N., Ashton, Trent D., Acharya, Rameshwor, Feng, Zikai, Gueven, Nuri, Pfeffer, Frederick M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232238/
https://www.ncbi.nlm.nih.gov/pubmed/34203745
http://dx.doi.org/10.3390/cells10061505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232238/
https://www.ncbi.nlm.nih.gov/pubmed/34203745
http://dx.doi.org/10.3390/cells10061505

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