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Reduced Quality of Life and Sexual Satisfaction in Isolated Hypogonadotropic Hypogonadism

(1) Background: Isolated hypogonadotropic hypogonadism (IHH) is a genetic condition characterized by impaired puberty and fertility. IHH can significantly impact patient health-related quality of life (HRQoL), sexual satisfaction (SS) and mood. (2) Methods: Participants included 132 IHH subjects (89...

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Autores principales: Kałużna, Małgorzata, Kompf, Pola, Rabijewski, Michał, Moczko, Jerzy, Kałużny, Jarosław, Ziemnicka, Katarzyna, Ruchała, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232286/
https://www.ncbi.nlm.nih.gov/pubmed/34198686
http://dx.doi.org/10.3390/jcm10122622
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author Kałużna, Małgorzata
Kompf, Pola
Rabijewski, Michał
Moczko, Jerzy
Kałużny, Jarosław
Ziemnicka, Katarzyna
Ruchała, Marek
author_facet Kałużna, Małgorzata
Kompf, Pola
Rabijewski, Michał
Moczko, Jerzy
Kałużny, Jarosław
Ziemnicka, Katarzyna
Ruchała, Marek
author_sort Kałużna, Małgorzata
collection PubMed
description (1) Background: Isolated hypogonadotropic hypogonadism (IHH) is a genetic condition characterized by impaired puberty and fertility. IHH can significantly impact patient health-related quality of life (HRQoL), sexual satisfaction (SS) and mood. (2) Methods: Participants included 132 IHH subjects (89 men and 43 women) and 132 sex- and age-matched controls. HRQoL, depressive symptoms, erectile dysfunction (ED), and SS were assessed in an online survey using the Zung Self-Rating Depression Scale (SDS), 15D instrument of HRQoL (15D), Sexual Satisfaction Questionnaire (SSQ), and 5-item International Index of Erectile Function (IIEF-5). (3) Results: QoL and SS were significantly lower in the IHH group vs. controls. There was a high rate of ED (53.2% vs. 33%, p = 0.008) and depressive symptoms (45.00 ± 17.00 vs. 32.00 ± 12.00, p < 0.001) in patients vs. controls. The age of patients at IHH diagnosis inversely correlated with their overall 15D scores. An alarming non-compliance rate was seen (51.6%). No differences were found between scores of patients receiving hormone replacement therapy (HRT) and untreated subjects in any of the scales. (4) Conclusions: The HRQoL, SS, ED, and depression levels observed in IHH patients, despite HRT, are alarming. Late IHH diagnosis may have a particularly negative impact on HRQoL. More attention should be devoted to HRT adherence and various HRQoL aspects of IHH patients.
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spelling pubmed-82322862021-06-26 Reduced Quality of Life and Sexual Satisfaction in Isolated Hypogonadotropic Hypogonadism Kałużna, Małgorzata Kompf, Pola Rabijewski, Michał Moczko, Jerzy Kałużny, Jarosław Ziemnicka, Katarzyna Ruchała, Marek J Clin Med Article (1) Background: Isolated hypogonadotropic hypogonadism (IHH) is a genetic condition characterized by impaired puberty and fertility. IHH can significantly impact patient health-related quality of life (HRQoL), sexual satisfaction (SS) and mood. (2) Methods: Participants included 132 IHH subjects (89 men and 43 women) and 132 sex- and age-matched controls. HRQoL, depressive symptoms, erectile dysfunction (ED), and SS were assessed in an online survey using the Zung Self-Rating Depression Scale (SDS), 15D instrument of HRQoL (15D), Sexual Satisfaction Questionnaire (SSQ), and 5-item International Index of Erectile Function (IIEF-5). (3) Results: QoL and SS were significantly lower in the IHH group vs. controls. There was a high rate of ED (53.2% vs. 33%, p = 0.008) and depressive symptoms (45.00 ± 17.00 vs. 32.00 ± 12.00, p < 0.001) in patients vs. controls. The age of patients at IHH diagnosis inversely correlated with their overall 15D scores. An alarming non-compliance rate was seen (51.6%). No differences were found between scores of patients receiving hormone replacement therapy (HRT) and untreated subjects in any of the scales. (4) Conclusions: The HRQoL, SS, ED, and depression levels observed in IHH patients, despite HRT, are alarming. Late IHH diagnosis may have a particularly negative impact on HRQoL. More attention should be devoted to HRT adherence and various HRQoL aspects of IHH patients. MDPI 2021-06-14 /pmc/articles/PMC8232286/ /pubmed/34198686 http://dx.doi.org/10.3390/jcm10122622 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kałużna, Małgorzata
Kompf, Pola
Rabijewski, Michał
Moczko, Jerzy
Kałużny, Jarosław
Ziemnicka, Katarzyna
Ruchała, Marek
Reduced Quality of Life and Sexual Satisfaction in Isolated Hypogonadotropic Hypogonadism
title Reduced Quality of Life and Sexual Satisfaction in Isolated Hypogonadotropic Hypogonadism
title_full Reduced Quality of Life and Sexual Satisfaction in Isolated Hypogonadotropic Hypogonadism
title_fullStr Reduced Quality of Life and Sexual Satisfaction in Isolated Hypogonadotropic Hypogonadism
title_full_unstemmed Reduced Quality of Life and Sexual Satisfaction in Isolated Hypogonadotropic Hypogonadism
title_short Reduced Quality of Life and Sexual Satisfaction in Isolated Hypogonadotropic Hypogonadism
title_sort reduced quality of life and sexual satisfaction in isolated hypogonadotropic hypogonadism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232286/
https://www.ncbi.nlm.nih.gov/pubmed/34198686
http://dx.doi.org/10.3390/jcm10122622
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