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Reduced Quality of Life and Sexual Satisfaction in Isolated Hypogonadotropic Hypogonadism
(1) Background: Isolated hypogonadotropic hypogonadism (IHH) is a genetic condition characterized by impaired puberty and fertility. IHH can significantly impact patient health-related quality of life (HRQoL), sexual satisfaction (SS) and mood. (2) Methods: Participants included 132 IHH subjects (89...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232286/ https://www.ncbi.nlm.nih.gov/pubmed/34198686 http://dx.doi.org/10.3390/jcm10122622 |
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author | Kałużna, Małgorzata Kompf, Pola Rabijewski, Michał Moczko, Jerzy Kałużny, Jarosław Ziemnicka, Katarzyna Ruchała, Marek |
author_facet | Kałużna, Małgorzata Kompf, Pola Rabijewski, Michał Moczko, Jerzy Kałużny, Jarosław Ziemnicka, Katarzyna Ruchała, Marek |
author_sort | Kałużna, Małgorzata |
collection | PubMed |
description | (1) Background: Isolated hypogonadotropic hypogonadism (IHH) is a genetic condition characterized by impaired puberty and fertility. IHH can significantly impact patient health-related quality of life (HRQoL), sexual satisfaction (SS) and mood. (2) Methods: Participants included 132 IHH subjects (89 men and 43 women) and 132 sex- and age-matched controls. HRQoL, depressive symptoms, erectile dysfunction (ED), and SS were assessed in an online survey using the Zung Self-Rating Depression Scale (SDS), 15D instrument of HRQoL (15D), Sexual Satisfaction Questionnaire (SSQ), and 5-item International Index of Erectile Function (IIEF-5). (3) Results: QoL and SS were significantly lower in the IHH group vs. controls. There was a high rate of ED (53.2% vs. 33%, p = 0.008) and depressive symptoms (45.00 ± 17.00 vs. 32.00 ± 12.00, p < 0.001) in patients vs. controls. The age of patients at IHH diagnosis inversely correlated with their overall 15D scores. An alarming non-compliance rate was seen (51.6%). No differences were found between scores of patients receiving hormone replacement therapy (HRT) and untreated subjects in any of the scales. (4) Conclusions: The HRQoL, SS, ED, and depression levels observed in IHH patients, despite HRT, are alarming. Late IHH diagnosis may have a particularly negative impact on HRQoL. More attention should be devoted to HRT adherence and various HRQoL aspects of IHH patients. |
format | Online Article Text |
id | pubmed-8232286 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82322862021-06-26 Reduced Quality of Life and Sexual Satisfaction in Isolated Hypogonadotropic Hypogonadism Kałużna, Małgorzata Kompf, Pola Rabijewski, Michał Moczko, Jerzy Kałużny, Jarosław Ziemnicka, Katarzyna Ruchała, Marek J Clin Med Article (1) Background: Isolated hypogonadotropic hypogonadism (IHH) is a genetic condition characterized by impaired puberty and fertility. IHH can significantly impact patient health-related quality of life (HRQoL), sexual satisfaction (SS) and mood. (2) Methods: Participants included 132 IHH subjects (89 men and 43 women) and 132 sex- and age-matched controls. HRQoL, depressive symptoms, erectile dysfunction (ED), and SS were assessed in an online survey using the Zung Self-Rating Depression Scale (SDS), 15D instrument of HRQoL (15D), Sexual Satisfaction Questionnaire (SSQ), and 5-item International Index of Erectile Function (IIEF-5). (3) Results: QoL and SS were significantly lower in the IHH group vs. controls. There was a high rate of ED (53.2% vs. 33%, p = 0.008) and depressive symptoms (45.00 ± 17.00 vs. 32.00 ± 12.00, p < 0.001) in patients vs. controls. The age of patients at IHH diagnosis inversely correlated with their overall 15D scores. An alarming non-compliance rate was seen (51.6%). No differences were found between scores of patients receiving hormone replacement therapy (HRT) and untreated subjects in any of the scales. (4) Conclusions: The HRQoL, SS, ED, and depression levels observed in IHH patients, despite HRT, are alarming. Late IHH diagnosis may have a particularly negative impact on HRQoL. More attention should be devoted to HRT adherence and various HRQoL aspects of IHH patients. MDPI 2021-06-14 /pmc/articles/PMC8232286/ /pubmed/34198686 http://dx.doi.org/10.3390/jcm10122622 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kałużna, Małgorzata Kompf, Pola Rabijewski, Michał Moczko, Jerzy Kałużny, Jarosław Ziemnicka, Katarzyna Ruchała, Marek Reduced Quality of Life and Sexual Satisfaction in Isolated Hypogonadotropic Hypogonadism |
title | Reduced Quality of Life and Sexual Satisfaction in Isolated Hypogonadotropic Hypogonadism |
title_full | Reduced Quality of Life and Sexual Satisfaction in Isolated Hypogonadotropic Hypogonadism |
title_fullStr | Reduced Quality of Life and Sexual Satisfaction in Isolated Hypogonadotropic Hypogonadism |
title_full_unstemmed | Reduced Quality of Life and Sexual Satisfaction in Isolated Hypogonadotropic Hypogonadism |
title_short | Reduced Quality of Life and Sexual Satisfaction in Isolated Hypogonadotropic Hypogonadism |
title_sort | reduced quality of life and sexual satisfaction in isolated hypogonadotropic hypogonadism |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232286/ https://www.ncbi.nlm.nih.gov/pubmed/34198686 http://dx.doi.org/10.3390/jcm10122622 |
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