Natural Polymer Chitosan as Super Disintegrant in Fast Orally Disintegrating Meloxicam Tablets: Formulation and Evaluation

The aim of the present investigation was to formulate fast disintegrating tablets of meloxicam by wet granulation technique using medium molecular weight chitosan. The orally disintegrating tablets of meloxicam with chitosan showed good mechanical and disintegration properties and good dissolution r...

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Detalles Bibliográficos
Autores principales: Draksiene, Gailute, Venclovaite, Brigita, Pudziuvelyte, Lauryna, Ivanauskas, Liudas, Marksa, Mindaugas, Bernatoniene, Jurga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232328/
https://www.ncbi.nlm.nih.gov/pubmed/34203634
http://dx.doi.org/10.3390/pharmaceutics13060879
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author Draksiene, Gailute
Venclovaite, Brigita
Pudziuvelyte, Lauryna
Ivanauskas, Liudas
Marksa, Mindaugas
Bernatoniene, Jurga
author_facet Draksiene, Gailute
Venclovaite, Brigita
Pudziuvelyte, Lauryna
Ivanauskas, Liudas
Marksa, Mindaugas
Bernatoniene, Jurga
author_sort Draksiene, Gailute
collection PubMed
description The aim of the present investigation was to formulate fast disintegrating tablets of meloxicam by wet granulation technique using medium molecular weight chitosan. The orally disintegrating tablets of meloxicam with chitosan showed good mechanical and disintegration properties and good dissolution rate when prepared in tablet press using 10.8 kN and 11.0 kN compression force. Chitosan is a suitable biopolymer to moderate the disintegration process in orally disintegrating tablets.
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spelling pubmed-82323282021-06-26 Natural Polymer Chitosan as Super Disintegrant in Fast Orally Disintegrating Meloxicam Tablets: Formulation and Evaluation Draksiene, Gailute Venclovaite, Brigita Pudziuvelyte, Lauryna Ivanauskas, Liudas Marksa, Mindaugas Bernatoniene, Jurga Pharmaceutics Article The aim of the present investigation was to formulate fast disintegrating tablets of meloxicam by wet granulation technique using medium molecular weight chitosan. The orally disintegrating tablets of meloxicam with chitosan showed good mechanical and disintegration properties and good dissolution rate when prepared in tablet press using 10.8 kN and 11.0 kN compression force. Chitosan is a suitable biopolymer to moderate the disintegration process in orally disintegrating tablets. MDPI 2021-06-15 /pmc/articles/PMC8232328/ /pubmed/34203634 http://dx.doi.org/10.3390/pharmaceutics13060879 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Draksiene, Gailute
Venclovaite, Brigita
Pudziuvelyte, Lauryna
Ivanauskas, Liudas
Marksa, Mindaugas
Bernatoniene, Jurga
Natural Polymer Chitosan as Super Disintegrant in Fast Orally Disintegrating Meloxicam Tablets: Formulation and Evaluation
title Natural Polymer Chitosan as Super Disintegrant in Fast Orally Disintegrating Meloxicam Tablets: Formulation and Evaluation
title_full Natural Polymer Chitosan as Super Disintegrant in Fast Orally Disintegrating Meloxicam Tablets: Formulation and Evaluation
title_fullStr Natural Polymer Chitosan as Super Disintegrant in Fast Orally Disintegrating Meloxicam Tablets: Formulation and Evaluation
title_full_unstemmed Natural Polymer Chitosan as Super Disintegrant in Fast Orally Disintegrating Meloxicam Tablets: Formulation and Evaluation
title_short Natural Polymer Chitosan as Super Disintegrant in Fast Orally Disintegrating Meloxicam Tablets: Formulation and Evaluation
title_sort natural polymer chitosan as super disintegrant in fast orally disintegrating meloxicam tablets: formulation and evaluation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232328/
https://www.ncbi.nlm.nih.gov/pubmed/34203634
http://dx.doi.org/10.3390/pharmaceutics13060879
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