Responsiveness to Hedgehog Pathway Inhibitors in T-Cell Acute Lymphoblastic Leukemia Cells Is Highly Dependent on 5′AMP-Activated Kinase Inactivation

Numerous studies have shown that hedgehog inhibitors (iHHs) only partially block the growth of tumor cells, especially in vivo. Leukemia often expands in a nutrient-depleted environment (bone marrow and thymus). In order to identify putative signaling pathways implicated in the adaptive response to...

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Detalles Bibliográficos
Autores principales: Tosello, Valeria, Bongiovanni, Deborah, Di Martino, Ludovica, Franchin, Cinzia, Zanovello, Paola, Arrigoni, Giorgio, Piovan, Erich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232330/
https://www.ncbi.nlm.nih.gov/pubmed/34203724
http://dx.doi.org/10.3390/ijms22126384

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