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Correlation between reported dengue illness history and seropositivity in rural Thailand

In the latest World Health Organization (WHO) recommendation for Dengvaxia implementation, either serological testing or a person’s history of prior dengue illness may be used as supporting evidence to identify dengue virus (DENV)-immune individuals eligible for vaccination, in areas with limited ca...

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Autores principales: Buddhari, Darunee, Anderson, Kathryn B., Gromowski, Gregory D., Jarman, Richard G., Iamsirithaworn, Sopon, Thaisomboonsuk, Butsaya, Hunsawong, Taweewun, Srikiatkhachorn, Anon, Rothman, Alan L., Jones, Anthony R., Fernandez, Stefan, Thomas, Stephen J., Endy, Timothy P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232416/
https://www.ncbi.nlm.nih.gov/pubmed/34129599
http://dx.doi.org/10.1371/journal.pntd.0009459
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author Buddhari, Darunee
Anderson, Kathryn B.
Gromowski, Gregory D.
Jarman, Richard G.
Iamsirithaworn, Sopon
Thaisomboonsuk, Butsaya
Hunsawong, Taweewun
Srikiatkhachorn, Anon
Rothman, Alan L.
Jones, Anthony R.
Fernandez, Stefan
Thomas, Stephen J.
Endy, Timothy P.
author_facet Buddhari, Darunee
Anderson, Kathryn B.
Gromowski, Gregory D.
Jarman, Richard G.
Iamsirithaworn, Sopon
Thaisomboonsuk, Butsaya
Hunsawong, Taweewun
Srikiatkhachorn, Anon
Rothman, Alan L.
Jones, Anthony R.
Fernandez, Stefan
Thomas, Stephen J.
Endy, Timothy P.
author_sort Buddhari, Darunee
collection PubMed
description In the latest World Health Organization (WHO) recommendation for Dengvaxia implementation, either serological testing or a person’s history of prior dengue illness may be used as supporting evidence to identify dengue virus (DENV)-immune individuals eligible for vaccination, in areas with limited capacity for laboratory confirmation. This analysis aimed to estimate the concordance between self-reported dengue illness histories and seropositivity in a prospective cohort study for dengue virus infection in Kamphaeng Phet province, a dengue-endemic area in northern Thailand. The study enrolled 2,076 subjects from 516 multigenerational families, with a median age of 30.6 years (range 0–90 years). Individual and family member dengue illness histories were obtained by questionnaire. Seropositivity was defined based on hemagglutination inhibition (HAI) assays. Overall seropositivity for DENV was 86.5% among those aged 9–45 years, which increased with age. 18.5% of participants reported a history of dengue illness prior to enrollment; 30.1% reported a previous DENV infection in the family, and 40.1% reported DENV infection in either themselves or a family member. Relative to seropositivity by HAI in the vaccine candidate group, the sensitivity and specificity of individual prior dengue illness history were 18.5% and 81.6%, respectively; sensitivity and specificity of reported dengue illness in a family member were 29.8% and 68.0%, and of either the individual or a family member were 40.1% and 60.5%. Notably, 13.4% of individuals reporting prior dengue illness were seronegative. Given the high occurrence of asymptomatic and mild DENV infection, self-reported dengue illness history is poorly sensitive for prior exposure and may misclassify individuals as ‘exposed’ when they were not. This analysis highlights that a simple, highly sensitive, and highly specific test for determining serostatus prior to Dengvaxia vaccination is urgently needed.
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spelling pubmed-82324162021-07-07 Correlation between reported dengue illness history and seropositivity in rural Thailand Buddhari, Darunee Anderson, Kathryn B. Gromowski, Gregory D. Jarman, Richard G. Iamsirithaworn, Sopon Thaisomboonsuk, Butsaya Hunsawong, Taweewun Srikiatkhachorn, Anon Rothman, Alan L. Jones, Anthony R. Fernandez, Stefan Thomas, Stephen J. Endy, Timothy P. PLoS Negl Trop Dis Research Article In the latest World Health Organization (WHO) recommendation for Dengvaxia implementation, either serological testing or a person’s history of prior dengue illness may be used as supporting evidence to identify dengue virus (DENV)-immune individuals eligible for vaccination, in areas with limited capacity for laboratory confirmation. This analysis aimed to estimate the concordance between self-reported dengue illness histories and seropositivity in a prospective cohort study for dengue virus infection in Kamphaeng Phet province, a dengue-endemic area in northern Thailand. The study enrolled 2,076 subjects from 516 multigenerational families, with a median age of 30.6 years (range 0–90 years). Individual and family member dengue illness histories were obtained by questionnaire. Seropositivity was defined based on hemagglutination inhibition (HAI) assays. Overall seropositivity for DENV was 86.5% among those aged 9–45 years, which increased with age. 18.5% of participants reported a history of dengue illness prior to enrollment; 30.1% reported a previous DENV infection in the family, and 40.1% reported DENV infection in either themselves or a family member. Relative to seropositivity by HAI in the vaccine candidate group, the sensitivity and specificity of individual prior dengue illness history were 18.5% and 81.6%, respectively; sensitivity and specificity of reported dengue illness in a family member were 29.8% and 68.0%, and of either the individual or a family member were 40.1% and 60.5%. Notably, 13.4% of individuals reporting prior dengue illness were seronegative. Given the high occurrence of asymptomatic and mild DENV infection, self-reported dengue illness history is poorly sensitive for prior exposure and may misclassify individuals as ‘exposed’ when they were not. This analysis highlights that a simple, highly sensitive, and highly specific test for determining serostatus prior to Dengvaxia vaccination is urgently needed. Public Library of Science 2021-06-15 /pmc/articles/PMC8232416/ /pubmed/34129599 http://dx.doi.org/10.1371/journal.pntd.0009459 Text en https://creativecommons.org/publicdomain/zero/1.0/This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Buddhari, Darunee
Anderson, Kathryn B.
Gromowski, Gregory D.
Jarman, Richard G.
Iamsirithaworn, Sopon
Thaisomboonsuk, Butsaya
Hunsawong, Taweewun
Srikiatkhachorn, Anon
Rothman, Alan L.
Jones, Anthony R.
Fernandez, Stefan
Thomas, Stephen J.
Endy, Timothy P.
Correlation between reported dengue illness history and seropositivity in rural Thailand
title Correlation between reported dengue illness history and seropositivity in rural Thailand
title_full Correlation between reported dengue illness history and seropositivity in rural Thailand
title_fullStr Correlation between reported dengue illness history and seropositivity in rural Thailand
title_full_unstemmed Correlation between reported dengue illness history and seropositivity in rural Thailand
title_short Correlation between reported dengue illness history and seropositivity in rural Thailand
title_sort correlation between reported dengue illness history and seropositivity in rural thailand
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232416/
https://www.ncbi.nlm.nih.gov/pubmed/34129599
http://dx.doi.org/10.1371/journal.pntd.0009459
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