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Identification of average molecular weight (AMW) as a useful chemical descriptor to discriminate liver injury-inducing drugs

Drug-induced liver injury (DILI) is one of major causes of discontinuing drug development and withdrawing drugs from the market. In this study, we investigated chemical properties associated with DILI using in silico methods, to identify a physicochemical property useful for DILI screening at the ea...

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Detalles Bibliográficos
Autores principales:	Shimizu, Yuki, Sasaki, Takamitsu, Takeshita, Jun-ichi, Watanabe, Michiko, Shizu, Ryota, Hosaka, Takuomi, Yoshinari, Kouichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232420/ https://www.ncbi.nlm.nih.gov/pubmed/34170966 http://dx.doi.org/10.1371/journal.pone.0253855

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